Olusola S. SAKA, A. Omobola KOMOLAFE, Oludare OGUNLADE, A. Rotimi OWOLABİ, A. Ahmed OLAYODE, E. Babatunde ARAYOMBO

Effects of aqueous extract of garlic (Allium sativum) on the left ventricle myocardium of high salt-fed adult Wistar rats

Objectives:The aim of this study was to evaluate the beneficial effect of aqueous extract of garlic (Allium sativum) on the morphology of myocardium of left ventricle in high salt-fed diet Wistar rats. Methods: Twenty-five female Wistar rats weighing 130-180 g were divided into five groups (n=5, each). Group A were fedwith standard laboratory pellets, while Groups B, C, D and E were fed a high-salt diet for five weeks. Following this, dailyadministration of aqueous garlic extract was done orally to Groups C, D and E, respectively for 3 weeks. The left ventricle ofthe heart was excised, processed in paraffin wax and stained with haematoxylin and eosin, Masson's trichrome andVerhoeff-Van Gieson stains. One-way ANOVA was used to analyze data, followed by Student-Newman-Keuls (SNK) test formultiple comparisons. Results: We found that the relative change in heart weight in the high salt-fed group was lower, though not statisticallysignificant (p=0.175) than the control group. There was significant increase (p

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