Monosit/Yüksek Yoğunluklu Lipoprotein Kolesterol Oranı Yüksekliği Orta Düzey Karotis Arter Darlığında Semptomatik Plak Için Öngördürücü Müdür?

Amaç: Monosit/yüksek yoğunluklu lipoprotein kolesterol oranı (MHR), inflamasyon ile pozitif ilişkili yeni ve kolayca ölçülebilen bir belirteçtir. Bu çalışmada orta düzey karotis arter darlığı olan hastalarda MHR ile semptomatik plak varlığı arasında bir ilişki olup olmadığını değerlendirmeyi amaçladık.

Anahtar Kelimeler:

Monosit/HDL-K oranı, karotis arter, semptomatik plak

Is Elevated Monocyte to High-Density Lipoprotein Ratio A Predictor of Symptomatic Plaque in Patients With İntermediate Carotid Artery Stenosis?

Aim: Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a new and easily measurable marker positively associated with inflammation. In this study, we aimed to evaluate if there was a relationship between MHR and the risk of presence of symptomatic plaque in patients with intermediate carotid artery stenosis.

Keywords:

Monocyte/HDL-C ratio, Carotid Artery, Symptomatic plaque,

PDF

___

Gorelick PB, Wong KS, Bae HJ, et al. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. 2008;39:2396-2399.
Hansson GK, Libby P, Schonbeck U, et al. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;91:281–91.
Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:2045-51.
Hristov M, Heine GH. Monocyte subsets in atherosclerosis. Hamostaseologie. 2015;35(2):105–12.
Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol. 2013;13:709–21.
Chapman CM, Beilby JP, McQuillan BM, et al. Monocyte count, but not c-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke. 2004;35:1619–24.
Matsumura T, Taketa K, Motoshima H, et al. Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes. Cardiovasc Diabetol. 2013;12:177.
Canpolat U, Çetin EH, Cetin S, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation. Clin Appl Thromb Hemost. 2016;22(5):476-82.
Liapis CD, Bell PR, Mikhailidis D, et al. ESVS guidelines. Invasive treatment for carotid stenosis: indications, techniques. Eur J Vasc Endovasc Surg 2009;37(4 Suppl):1-19.
Brott TG, Halperin JL, Abbara S, et al. ASA / ACCF /AHA / AANN / AANS / ACR / ASNR / CNS / SAIP / SCAI / SIR / SNIS / SVM / SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary: a report. J Am Coll Cardiol. 2011;57:1002-1044. Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92:7e32.
Cybulsky MI, Gimbrone JrMA. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788e91.
Ghattas A, Griffiths HR, Devitt A, et al. Monocytes in coronary artery disease and atherosclerosis: where are we now? J Am Coll Cardiol. 2013;62(17):1541-1551.
Murphy AJ, Chin-Dusting JP, Sviridov D, et al. The anti inflammatory effects of high density lipoproteins. Curr Med Chem. 2009;16(6):667-675.
.Murphy AJ, Woollard KJ. High-density lipoprotein: a potent inhibitor of inflammation. Clin Exp Pharmacol Physiol. 2010;37(7):710-718.
Yvan-Charvet L, Pagler T, Gautier EL, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010;328(5986):1689-1693.
Li XP, Zhao SP, Zhang XY, et al. Protective effect of high density lipoprotein on endothelium dependent vasodilatation. Int J Cardiol. 2000;73(3):231-236 . Kuvin JT, Ramet ME, Patel AR, et al. A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. Am Heart J. 2002;144(1):165-172.
Kuvin JT, Patel AR, Sidhu M, et al. Relation between high-density lipoprotein cholesterol and peripheral vasomotor function. Am J Cardiol. 2003;92(3):275-279.
Acikgoz N, Kurtoglu E, Yagmur J, et al. Elevated monocyte to high-density lipoprotein cholesterol ratio and endothelial dysfunction in behcet disease. Angiology. 2018;69:65–70.
Chen JW, Li C, Liu ZH, et al. The role of monocyte to high-density lipoprotein cholesterol ratio in rrediction of carotid intima-media thickness in patients with type 2 diabetes. Front Endocrinol (Lausanne). 2019;10:191.
Wu TT, Zheng YY, Chen Y, et al. Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention. Lipids Health Dis. 2019;18(1):180.
Bolayir A, Gokce SF, Cigdem B, et al. Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol. 2018;52(2):150-155.
Enhos A, Cosansu K, Huyut MA et al. Assessment of the relationship between monocyte to high-density lipoprotein ratio and myocardial bridge. Arq Bras Cardiol. 2019;112(1):12-17.
Kundi H, Gok M, Kiziltunc E, et al. Relation between monocyte to high-density lipoprotein cholesterol ratio with presence and severity of isolated coronary artery ectasia. Am J Cardiol. 2015;116(11):1685-9.
Köklü E, Yüksel İÖ, Arslan Ş, et al. Is elevated neutrophil-to-lymphocyte ratio a predictor of stroke in patients with intermediate carotid artery stenosis? J Stroke Cerebrovasc Dis. 2016;25(3):578-84.