Valproik Asit Kullanımına Bağlı Trombositopeni ve Fulminan Karaciğer Yetersizliği: Olgu Sunumu

İlaç kullanımına bağlı hepatotoksisiteler, asemptomatik karaciğer enzim yüksekliğinden, yoğunbakım şartlarında multidisipliner takibi gereken ve tek tedavisinin karaciğer transplantasyonuolduğu fulminan karaciğer yetersizliği arasında geniş bir yelpazede izlenirler. İlaç kullanımınabağlı karaciğer yetmezliği karaciğer transplantasyonunun sık gözlenen endikasyonudur. İlaçkullanımına bağlı fulminan karaciğer yetersizliğinde karaciğer transplantasyonu yapılamamasımortal iken, transplantasyonun gecikmesi de morbiditeye neden olmaktadır. Bu vaka sunumunda yirmi yaşında erkek hastada, valproik asit kullanımına bağlı trombositopeni ve fulminankaraciğer yetersizliği gelişmiş ve karaciğer transplantasyonu ile şifa sağlanmıştır. Fulminankaraciğer yetersizliği gelişen olgularda karaciğer transplantasyonu hayat kurtarıcıdır.

Thrombocytopenia And Fulminant Hepatic Failure Due To Valproic Acid Use: A Case Report

Drug-induced hepatotoxicity is observed in a wide range from asymptomatic liver enzyme elevation to fulminant hepatic insufficiency, which requires multidisciplinary follow-up under intensive care and the only treatment is liver transplantation. Drug-induced liver failure is a common indication for liver transplantation. In fulminant hepatic failure due to drug use, failure to transplant liver is mortal, while delayed transplantation causes morbidity. In this case report, thrombocytopenia and fulminant hepatic failure due to valproic acid use developed in a 20-year-old male patient and healed with liver transplantation. Liver transplantation is life-saving in patients with fulminant hepatic failure.

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