TARİHİ PERSPEKTİFLE SOLID ORGAN VE KOMPOZIT DOKU NAKILLERINDEKI GELIŞMELER

ÖZ Hastalıklı ve fonksiyon görmeyen bir organ yerine başka canlıdan alınan aynı organın nakledilmesi fikri çok eski çağlara dayanır. Ancak günümüzde erişilen düzey ve standartları sağlayan bilimsel buluşlar ve gelişmeler 19. yüzyıl sonu ve özellikle 20. yüzyıl ikinci yarısında gerçekleşmiştir. Böbrek, karaciğer ve kornea nakilleri yaygın olarak düşük morbidite ve mortalite ile uygulanan cerrahi işlemlerdir. Kalp, akciğer, pankreas ve ince barsak nakilleri de özellikle son dekadda sıklıkla yapılan nakiller arasına girmiştir. Uterus, kompozit ekstremite ve fasial nakiller daha yeni ve farklı endikasyonlarla yapılan ve günümüzde daha nadir uygulanan işlemler arasında sayılabilir. Organ nakli bazı son evre kronik hastalıkların tedavisinde kesin çözüm olmasına karşın organ teminindeki yetersizlik değişik tedavi modalitelerinin geliştirilmesini ve yeni araştırma alanlarında çalışmayı kaçınılmaz kılmaktadır. Anahtar Sözcükler: Komposit Doku, Ekstremite,Yüz, Uterus, Transplantasyon

Anahtar Kelimeler:

Kompozit Doku, Ekstremite, Yüz, Uterus, Transplantasyon

The Achievements In Solid Organ and Composite Tissue Transplantation: A Historical Perspective

ABSTRACT The idea of replacing an affected non-functioning organ with the same organ from a living organism dates back to anticient times. However, scientific discoveries and developments that provide the current level and the standards took place in late nineteenth century and more profoundly in the second half of the twentieth century. Kidney, liver and corneal transplants are surgical procedures that are commonly performed with low morbidity and mortality. Heart, lung, pancreas and small intestine transplants are the second most common transplants. Uterus, composite extremity and facial transplants are transplants performed with newer and different indications. Although organ transplantation is the definitive solution in the treatment of some end stage chronic diseases, the inadequacy of organ supply makes it inevitable to develop different treatment modalities and to work in new research areas. Key Words: Composite Tissue, Limb, Face, Uterus, Transplantation

Keywords:

Composite Tissue, Limb, Face, Uterus, Transplantation,

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1. Marino IR, Cirillo C. An Abridged Photographic History of Organ Transplantation. Exp Clin Transplant 2014; Suppl 1:11-16.
2. Barker CF, Markmann JF. Historical overview of Transplantation. Cold Spring Har Perspect in Med 2013;3(4): a014977.
3. Merrill JP, Murray JE, Harrison JH, Guild WR. Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc 1956;160(4):277-282.
4. Merrill JP, Murray JE, Harrison JH Friedman EA, Dealy JB Jr, Dammin GJ. Succesful homotransplantation of the kidney between nonidentical twins. N Eng J Med 1960;262(25):1251-1260.
5. Toledo-Pereyra LH. Heart transplantation. J Invest Surg 2010;23(1):1-5.
6. Hardy JD. The first lung transplant in man (1963) and the first heart transplant in man (1964). Transplant Proc 1999;31(1-2):25-29.
7. Gül Dabak, Şenbaklavacı Ö. History of Lung Transplantation. Turk Thorac J 2016;17(2):71-75.
8. Gilbert R. Hand transplanted from cadaver is reamputated. Med Trib Med News 1964; 5:23-25.
9. Dubernard JM, Owen E, Herzberg G, Lanzetta M, Martin X, Kapilla H, Dawahra M, Hakim NS. Human hand allograft: report on first 6 months. Lancet 1999;353(9161):1315-1320.
10. Dubernard JM, Petruzzo P, Lanzetta M, Parmentier H, Martin X, Dawahra M, Hakim NS, Owen E. Functional results of the human double-hand transplantation. Ann Surg 2003;238(1): 128-136.
11. Shores JT, Malek V, Lee WPA, Brandacher G. Outcomes after hand and upper extremity transplantation. J Mater Sci Mater Med 2017;28(5):72.
12. Salminger S, Sturma A, Roche AD, Hruby LA, Paternostro-Sluga T, Kumnig M, Ninkovic M, Pierer G, Schneeberger S, Gabl M, Chelmonski J, Aszmann OC. Functional and psychosocial outcomes of hand transplantation compared with prosthetic fitting in below-elbow amputees: a multicenter cohort study. PLos One 2016; 11(9):e0162507.
13. Eun SC.[ Facial Transplantation Surgery Introduction]. J Korean Med Sci 2015; 30(6):669-672.
14. Gordon CR, Susarla SM, Peacock ZS,Kaban LB, Yaremchuk MJ.[LeFort-based maxillofacial transplantation: current state of art and a refined technique using orthognathic applications]. J Craniofacial Surg 2012; 23(1):81-87.
15. Lascar I, Zamfirescu D.[Update in Plastic surgery: Facial Transplantation]. Maedica (Buchar) 2012; 7(1):97-98.
16. Dubernard JM,Lengelé B, Morelon E, Testelin S, Badet L, Moure C Ph.D, Beziat JL, Stéphanie Dakpé S, Jean Kanitakis J, D'Hauthuille C, Jaafari AE, Petruzzo P. Outcomes 18 months after the first Human Partial Face transplantation. N Eng J Med 2007;357:2451-2460.
17. Lee ZH, Lopez CD, Plana NM, Caplan AL, Rodriguez ED. Are we prepared for the Inevitable ? A survey on Defining and Managing Failure in Face Transplantation. Plast Reconstr Surg Glob Open 2019;7(5):e2055.
18. Petruzzo P, Kantakis J, Testelin S, Pialat JB, Buron F, Badet L, Thaunat O, Devauchelle B, Morelon E. Clinicopathologic findings of chronic rejection in a face grefted patient]. Transplantation 2015;99(12):2644-2650.
19. Özkan Ö, Özkan Ö, Doğan U, Yılmaz VT, Uysal H, Ündar L, Doğan EA , Salim O, Çinpolat A, Ramazanoglu A. Considerations of difficulties and exit strategies in a case of face allotransplantation resulting in failure. Microsurgery 2017;37(6):661-668.
20. Eraslan S, Hamernik RJ, Hardy JD. Replantation of uterus and ovaries in dogs with successful pregnancy. Arch Surg 1966;92(1):9-12.
21. Fageeh W, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. Int J Gynaecol Obstet 2002;76(3):245-251.
22. Akar EM, Ozkan O, Aydinuraz B, Dirican K, Cincik M, Mendilcioglu I. Clinical pregnancy after uterus transplantation. Fertil Steril 2013;100(5):1358-1363.
23. Brännström M, Johannesson L, Bokström H, Kvarnström N, Mölne J, Dahm-Kahler P, Enskog A, Milenkovic M, Ekberg J, Diaz-Garcia C, Gäbel M, Hanafy A, Hagberg H, Olausson M, Nilsson L. Livebirth after uterus transplantation. Lancet 2015;385(9968):607-616.
24. Berkane N, Braneti R, Streuli I, Martinez DT, Dubuisson J. Uterine transplant: Clinical and ethical challanges in Switzerland. Rev Med Suisse 2020 16(676-677):42-46.
25. Kisu I, Kato Y, Obara H, Matsubara K, Motaba Y, Banno K, Aoki D. Emerging problems in uterus transplantation. BJOG 2018;125:1352-1356.
26. Wei L, Xue T, Tao KS, Zhang G, Zhao GY, Yu Q, Heng L,Yang ZX, Zheng MJ, Li F,Wang Q, Han Y, Shi YQ, Dong HL,Lu ZH,Wang Y, Yang H, Ma XD, Liu SJ, Liu HX, Xiong Z, Chen BL. Modified human uterus transplantation using ovarian veins for venous drainage: the first report of surgically successful robotic-assissted uterus procurement and follow-up for 12 months. Fertil Steril. 2017;108(2):346-356.e1.
27. Chmel R, Pastor Z, Matecha J, Janousek L, Novackova M, Fonek J. Uterine transplantation in an era of successful child births from living and deceased donor uteri. Current challanges. Biomed Pap Med Fac Univ Palaccky Olomouc Czech Repub.2020;164(1):115-120.
28. Lefkowitz A, Edwards M, Balayla J.[ The Montral Criteria for the Ethical Feasibility of Uterus Transplanatation]. Transplant Int 2012;25(4):439-447.
29. White RJ, Wolin LR, Massopust LC, Jr, Taslitz N, Verdura J. [Primate cephalic transplantation: Neurogenic separation, vascular association]. Transplant Proc 1971;3:602
30. Canavero S.HEAVEN.[ The Head Anastomosis venture outline Project for the first head transplantation with spinal linkage(GEMINI]). Surg Neurol Int 2013; 4(Suppl 1):S335-342
31. Ren S, Liu ZH, Wu Q, Fu K, Wu J, Hou LT, Li M, Zhao X, Miao Q, Zhao YL, Wang SY, Xu Y, Xue Z, Guo YS, Canavero S, Ren XP.Polyethylene glycol-induced motor recovery after total spinal transection in rats. CNS Neurosci Ther 2017; 23(8):680-685.
32. Starzl TE. History of Clinical Transplantation.World J Surg 2000; 24(7): 759–782.