Hacer Berna AFACAN ÖZTÜRK, Abdulkerim YILDIZ, Murat ALBAYRAK, Senem MARAL, Pınar CÖMERT, Buğra SAĞLAM, Mesut TIĞLIOĞLU

Diffüz Büyük B Hücreli Lenfoma Tanılı Hastalarda Tanıdaki Tam Kan Parametrelerinin Prognostik Önemi

Amaç: Diffüz büyük b hücreli lenfoma DBBHL tanısı alan hastalarda tam kan sayımı ve ilişkili bileşenleri, prognozun belirlenmesinde basit, ucuz, kolaylıkla yorumlanabilen ve yaygın olarak kullanılan markerlardan biridir. Çalışmanın amacı, DBBHL hastalarında tam kan sayımı parametreleri ile ilişkili bileşenlerin prognostik rolünü değerlendirmektir. Gereç ve Yöntemler: Retrospektif olarak 2011-2017 yıllarında DBBHL tanısı almış ve toplam 6 kür R-CHOP kemoterapisi ile tedavi edilmiş hastaların tanıdaki nötrofil/lenfosit oranına NLR , lenfosit-monosit oranına LMR ve Platelet-lenfosit oranına PLR bakıldı ve progresyonsuz sağkalım PFS ve genel sağkalım OS analizi yapıldı. Bulgular: Çalışmaya 66 hasta dahil edildi. Cox-Regresyon Modelinde, yüksek NLR ve düşük LMR kısa OS ve PFS ile ilişkiliydi; yüksek PLR, kısa PSF ile ilişkiliydi.Sonuç: Çalışmamızın sonucunda tedavi öncesi NLR, LMR, PLR değerlerinin DBBHL hastalarında bağımsız prognostik faktör olarak kullanılabileceğini gösterir

Anahtar Kelimeler:

Nötrofil/lenfosit oranı, Lenfosit-monosit oranı, Platelet-lenfosit oranı, Diffüz

The Prognostic Value of Blood Count Parameters in Patients with Diffuse Large B Cell Lymphoma

Objective: Full blood count with the associated components is a widely used marker in the diagnosis of patients with diffuse large B cell lymphoma DLBCL as it is simple and inexpensive and can be easily interpreted. The aim of the current study was to evaluate the prognostic role of complete blood count parameters with the associated components in patients with DLBCL.Material and Methods: In this retrospective study, the neutrophil/lymphocyte ratio NLR , lymphocyte/monocyte ratio LMR , and platelet/lymphocyte ratio PLR were evaluated and an analysis was made of the progression-free survival PFS and overall survival OS in patients who were diagnosed with DLBCL and treated with a total of 6 cycles of R-CHOP chemotherapy in the 2011-2017 period.Results: 66 patients were included in the study. In the Cox-Regression Model, high NLR and the low LMR were associated with short OS and PFS; high PLR was associated with short PSF.Conclusion: Pre-treatment NLR, LMR, and PLR values can be used as prognostic factors in DLBCL patients

Keywords:

Neutrophil/Lymphocyte ratio, Lymphocyte/Monocyte ratio, Platelet/Lymphocyte,

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