Kanserin Önlenmesi ve Tedavisinde Aralıklı Açlığın Etkisi

Kanser, hem ülkemiz hem de dünyada en önde gelen ölüm nedenlerinden biridir. Bu nedenle mevcut tedavilerin yanında kanserin önlenmesi ve tedavisinde yeni arayışlara girilmiştir. İnsan vücudunda pek çok mekanizmayı etkileyerek etki gösteren ve enerji kısıtlaması ile birlikte öğün zamanlamasını da içeren aralıklı açlık, günümüzde vücut ağırlığı kaybının yanı sıra pek çok hastalığın tedavisi ve sağlığın korunmasında tercih edilebilmektedir. Aralıklı açlık, temelde oksidatif stres, inflamasyon, DNA hasarı ve büyüme faktörleri gibi pek çok metabolik yolak üzerinden etki gösterebilmektedir. Bu durum aralıklı açlığın hem kanserin önlenmesi hem de kemoterapi yan etkilerinin azaltılması ve metabolik parametrelerin iyileşmesi gibi etkileri nedeniyle kanser tedavisinde de kullanılabileceğini göstermiştir. Fakat aralıklı açlık ile birlikte enerji alımında oluşan azalmanın kanserli bireylerde ağırlık kaybına neden olmasının bununla birlikte metabolik ve oksidatif stres durumunun yaşanmasının olumsuz etkiye neden olabileceği düşünülmektedir. Ayrıca aralıklı açlık ve kanser ilişkisinin netleşmesi için yeterli klinik düzeyde çalışmanın bulunmadığı da bildirilmektedir. Bu derlemede aralıklı açlık ve kanser ilişkisinde güncel literatürün özetlenmesi amaçlanmıştır.

Anahtar Kelimeler:

Kanser, Tümör, Aralıklı açlık, Diyet, Cancer, Tumor, İntermittent fasting, Diet

Effect of Intermittent Fasting on Cancer Prevention and Cancer Treatment

Cancer is one of the leading causes of death both in our country and in the world. For this reason, new searches have been made in the prevention and treatment of cancer in addition to existing treatments. Intermittent fasting, which affects many mechanisms in the human body and includes energy restriction and meal timing, can be preferred for the treatment of many diseases and protection of health, as well as body weight loss. Intermittent fasting can affect many metabolic pathways such as oxidative stress, inflammation, DNA damage and growth factors. This has shown that intermittent fasting can also be used in prevention of cancer and cancer treatment because of its effects such as reduction of chemotherapy side effects and improvement of metabolic parameters. However, it is thought that the decrease in energy intake with intermittent fasting causes weight loss in individuals with cancer, and metabolic and oxidative stress may cause negative effects. It is also reported that there are not enough clinical studies to clarify the relationship between intermittent fasting and cancer. In this review, it is aimed to summarize the current literature on the relationship between intermittent fasting and cancer.

Keywords:

Cancer, Tumor, İntermittent fasting, Diet,

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