Remzi GONUL, Lora KOENHEMSİ, Handan AYDIN, Tevfik GULYASAR, Hasret DEMIRCAN YARDIBI, Erman OR, Gulhan HOSTURK, Abdulkadir UYSAL, Bora BARUTCU

Tarantula Cubensis Ekstraktının Koyunlardaki Elektrokardiyografik Durum ve İz Elementler Üzerindeki Etkileri

Bu çalışmanın amacı Tarantula cubensis ekstratının (Theranekron, 1:100/D2, Richter Pharma, Avusturya) koyunlardaki bazı serum enzimleri, iz elementler ve kardiovasküler sistem üzerine olan etkilerini incelemektir. Bu çalışmada 7 koyun (6 aylık, 35±10 kg) kullanılmıştır. Theranekron 3 ml dozunda subcutan olarak uygulanmıştır. Serum üre, kreatinin, ALT, ALP, G-GT, LDH, Ca ve P seviyelerinin arttığı ve Total Protein, Mg, Cu, Fe, Zn ve Se seviyelerinin azaldığı belirlenmiştir. Threnekronla tedaviden sonra kardiovasküler system üzerine görülen önemli sonuçlar kan basıncının artması ve EKG üzerindeki değişimlerdir. Theranekron tedavisinin koyunlarda yan etkileri olabileceğine ve Theranekronun etkinliği üzerine daha fazla çalışma yapılması gerektiğine karar verilmiştir.

Anahtar Kelimeler:

Tarantula cubensis extract, sheep, ECG, trace elements

Effects of Tarantula Cubensis Extract on Electrocardiographic and Trace Element Status in Sheep

The purpose of this research was to investigate the acute effects of Tarantula cubensis extract (Theranekron, 1:100/D2, Richter Pharma, Austria) on some serum enzymes and trace elements, and the cardiovascular system in sheep. Seven sheep (age 6 months, 35±10 kg) were used in this study. Theranekron was applied in 6 ml doses subcutaneously. It was determined that in the serum Urea, Creatinin, ALT, ALP, G-GT, LDH, Ca and P levels were increased and T. protein, Mg, Cu, Fe, Zn and Se levels were decreased. The important results obtained after the treatment with Theranekron on cardiovascular system were blood pressure increases and some morphological changes in ECG. We concluded the Theranekron treatment can cause adverse effects in sheep and further investigation of the efficacy of Theranekron treatment is warranted.

Keywords:

Tarantula cubensis ekstraktı, koyun, EKG, iz elementler,

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