Use of corticosteroids is not associated with repeated vertebroplasty or kyphoplasty within one year after the surgery in patient older than 50 years
Objective: The aim of this study was to investigate whether corticosteroid use increases the incidence of repeated PVP or kyphoplasty patients older than 50 years. Methods: This study enrolled the data of 2,753 eligible patients from the Taiwan National Health Insurance Research Database who were exposed to systemic corticosteroids for at least 3 months during the first year preceding the first PVP or kyphoplasty. These steroid users were matched 1:1 in age, sex, and the index date of surgery with non-user controls during the enrollment period. All patients were followed for 1 year after the first PVP or kyphoplasty. The incidence of repeated PVP or kyphoplasty was compared between the steroid users and controls. A Cox proportional hazards model was developed to account for multiple confounding factors. Results: The number of patients receiving repeated PVP or kyphoplasty was 233 (8.46%) and 205 (7.45%) in the corticosteroid and control groups, respectively. The Cox proportional hazards model revealed no association between corticosteroid use and repeated PVP or kyphoplasty. Conclusions: Systemic corticosteroid use for longer than 3 months is not associated with repeated PVP or kyphoplasty within one year of surgery in patient older than 50 years old. Level of evidence: Level III, Therapeutic study.
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1. Hall SE, Criddle RA, Comito TL, Prince RL. A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. Osteoporos Int J Establ Res Coop Bet Eur Found Osteoporos Natl Osteoporos Found USA. 1999;9:508e515.2. Sambrook P, Cooper C. Osteoporosis. Lancet (London, England). 2006;367: 2010e2018.
3. Phillips FM. Minimally invasive treatments of osteoporotic vertebral compression fractures. Spine. 2003;28:S45eS53.
4. Johnell O, Kanis JA, Oden A, et al. Mortality after osteoporotic fractures. Osteoporos Int J Establ Res Coop Bet Eur Found Osteoporos Natl Osteoporos Found USA. 2004;15:38e42.
5. Kanis JA, Pitt FA. Epidemiology of osteoporosis. Bone. 1992;13:S7eS15.
6. Ploeg WT, Veldhuizen AG, The B, Sietsma MS. Percutaneous vertebroplasty as a treatment for osteoporotic vertebral compression fractures: a systematic review. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deformity Soc Eur Sect Cerv Spine Res Soc. 2006;15:1749e1758.
7. Mudano AS, Bian J, Cope JU, et al. Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: a population-based cohort study. Osteoporos Int J Establ Res Coop Bet Eur Found Osteoporos Natl Osteoporos Found USA. 2009;20:819e826.
8. Boger A, Heini P, Windolf M, Schneider E. Adjacent vertebral failure after vertebroplasty: a biomechanical study of low-modulus PMMA cement. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deformity Soc Eur Sect Cerv Spine Res Soc. 2007;16:2118e2125.
9. Trout AT, Kallmes DF, Kaufmann TJ. New fractures after vertebroplasty: adjacent fractures occur significantly sooner. AJNR Am J Neuroradiol. 2006;27: 217e223.
10. Voormolen MH, Lohle PN, Juttmann JR, van der Graaf Y, Fransen H, Lampmann LE. The risk of new osteoporotic vertebral compression fractures in the year after percutaneous vertebroplasty. J Vasc Interv Radiol JVIR. 2006;17: 71e76.
11. Tseng YY, Yang TC, Tu PH, Lo YL, Yang ST. Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty. Spine. 2009;34:1917e1922.
12. Ledlie JT, Renfro MB. Kyphoplasty treatment of vertebral fractures: 2-year outcomes show sustained benefits. Spine. 2006;31:57e64.
13. Uppin AA, Hirsch JA, Centenera LV, Pfiefer BA, Pazianos AG, Choi IS. Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology. 2003;226:119e124.
14. Fribourg D, Tang C, Sra P, Delamarter R, Bae H. Incidence of subsequent vertebral fracture after kyphoplasty. Spine. 2004;29:2270e2276. discussion 2277.
15. Garfin SR, Yuan HA, Reiley MA. New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine. 2001;26:1511e1515.
16. Harrop JS, Prpa B, Reinhardt MK, Lieberman I. Primary and secondary osteoporosis' incidence of subsequent vertebral compression fractures after kyphoplasty. Spine. 2004;29:2120e2125.
17. Lindsay R, Silverman SL, Cooper C, et al. Risk of new vertebral fracture in the year following a fracture. Jama. 2001;285:320e323.
18. Ross PD, Davis JW, Epstein RS, Wasnich RD. Pre-existing fractures and bone mass predict vertebral fracture incidence in women. Ann Intern Med. 1991;114: 919e923.
19. Tatsumi RL, Ching AC, Byrd GD, Hiratzka JR, Threlkeld JE, Hart RA. Predictors and prevalence of patients undergoing additional kyphoplasty procedures after an initial kyphoplasty procedure. Spine J Off J North Am Spine Soc. 2010;10: 979e986.
20. Lin WC, Lee YC, Lee CH, et al. Refractures in cemented vertebrae after percutaneous vertebroplasty: a retrospective analysis. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deformity Soc Eur Sect Cerv Spine Res Soc. 2008;17:592e599.
21. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373e383.
22. Pereira RM, Carvalho JF, Paula AP, et al. Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis. Rev Bras Reumatol. 2012;52: 580e593.
23. van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroidinduced osteoporosis: a meta-analysis. Osteoporos Int J Establ Res Coop Bet Eur Found Osteoporos Natl Osteoporos Found USA. 2002;13:777e787.
24. Papierska L, Rabijewski M. [Glucocorticoid-induced osteoporosis]. Pol Arch Med Wewnetrznej. 2007;117:363e369.
25. Kaji H, Yamauchi M, Chihara K, Sugimoto T. The threshold of bone mineral density for vertebral fracture in female patients with glucocorticoid-induced osteoporosis. Endocr J. 2006;53:27e34.
26. Angeli A, Guglielmi G, Dovio A, et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a cross-sectional outpatient study. Bone. 2006;39:253e259.
27. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C. Use of oral corticosteroids and risk of fractures. J Bone Miner Res Official J Am Soc Bone Miner Res. 2005;(20):1487e1494. discussion 1486.
28. Kado DM, Browner WS, Palermo L, Nevitt MC, Genant HK, Cummings SR. Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1999;159: 1215e1220.
29. Donovan MA, Khandji AG, Siris E. Multiple adjacent vertebral fractures after kyphoplasty in a patient with steroid-induced osteoporosis. J Bone Miner Res Official J Am Soc Bone Miner Res. 2004;19:712e713.
30. Lyles KW. Management of patients with vertebral compression fractures. Pharmacotherapy. 1999;19:21se24s.
31. Pluijm SM, Tromp AM, Smit JH, Deeg DJ, Lips P. Consequences of vertebral deformities in older men and women. J Bone Miner Res Official J Am Soc Bone Miner Res. 2000;15:1564e1572.
32. Mandel S, Schilling J, Peterson E, Rao DS, Sanders W. A retrospective analysis of vertebral body fractures following epidural steroid injections. J Bone Jt Surg Am Vol. 2013;95:961e964.
33. Ioannidis G, Pallan S, Papaioannou A, et al. Glucocorticoids predict 10-year fragility fracture risk in a population-based ambulatory cohort of men and women: Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos. 2014;9:169.
34. Jankovic T, Svorcan JZ, Boskovic K. Verification of osteoporotic vertebral fractures caused by glucocorticoids. Med Pregl. 2014;67:118e122.
35. Syed MI, Patel NA, Jan S, Shaikh A, Grunden B, Morar K. Symptomatic refractures after vertebroplasty in patients with steroid-induced osteoporosis. AJNR Am J Neuroradiol. 2006;27:1938e1943.
36. Hiwatashi A, Westesson PL. Patients with osteoporosis on steroid medication tend to sustain subsequent fractures. AJNR Am J Neuroradiol. 2007;28: 1055e1057.
37. Heo DH, Chin DK, Yoon YS, Kuh SU. Recollapse of previous vertebral compression fracture after percutaneous vertebroplasty. Osteoporos Int J Establ Res Coop Bet Eur Found Osteoporos Natl Osteoporos Found USA. 2009;20: 473e480.
38. Migita K, Iwanaga N, Imadachi S, et al. Incidence of symptomatic vertebral fractures among newly diagnosed autoimmune diseases initiating glucocorticoid therapy. Medicine. 2015;94:e875.
39. Tatsuno I, Suzuki S, Yoshida T, et al. Disease-related risk of vertebral fracture during glucocorticoid treatment of collagen vascular diseases. J Rheumatol. 2011;38:2270e2272.
40. Sugiyama T, Suzuki S, Yoshida T, et al. Incidence of symptomatic vertebral fractures in women of childbearing age newly treated with high-dose glucocorticoid. Gend Med. 2010;7:218e229.
41. Majumdar SR, Villa-Roel C, Lyons KJ, Rowe BH. Prevalence and predictors of vertebral fracture in patients with chronic obstructive pulmonary disease. Respir Med. 2010;104:260e266.
42. Drees BM. Repeated vertebral compression fractures during hypoglycemia unawareness. Diabet Care. 1994;17:1076e1077.
- ISSN: 1017-995X
- Başlangıç: 2015
- Yayıncı: Türk Ortopedi ve Travmatoloji Derneği
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