Çok Erken Nüks Eden Overin Juvenil Granuloza Hücreli Tümörü: Olgu Sunumu

Overin granüloza hücreli tümörü tüm over malignitelerinin %2-5'ini, juvenil granüloza hücreli tümör ise granuloza hücreli tümörlerin %5'ini oluşturmaktadır. Genellikle puberte öncesi dönemde ve genç kadınlarda karşımıza çıkar. Erken evrede tanı alırsa iyi gidişlidir fakat ileri evrede tanı aldığında daha agresif bir seyir göstermektedir. Burada 23 yaşında tanı alan evre 1A olmasına rağmen postoperatif 2. ayında nükseden overin juvenil granuloza hücreli tümörü tanılı bir olguyu sunduk.

Very Early Recurrence Juvenile Granulosa Cell Tumor of the Ovary: A Case Report

Granulosa cell tumors of the ovary constitute 2-5% of all ovarian malignancies and juvenile subtypes of granulosa cell tumors constitute 5% of the granulosa cell tumors. We usually face with juvenile granulosa cell tumor in the early stages of puberty and in young women. Disease course is better with the diagnosis in early stages but it shows aggressive behavior when diagnosed at an advanced stage. We present 23 years old case with stage 1 juvenile granulosa cell tumor that have a recurrence in the second months of operation.

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  • Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 2005;18Suppl 2:S81-93
  • Lack EE, Perez-Atayde AR, Murthy AS, et al. Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases. Cancer 1981;48:1846-54
  • Colombo N, Parma G, Zanagnolo V, Insinga A. Management of ovarian stromal cell tumors. J Clin Oncol 2007:25:2944-51
  • Boyce EA, Costaggini I, Vitonis A, et al. The epidemiology of ovarian granulosa cell tumors: a case-control study. Gynecol Oncol 2009;115:221-5
  • Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol 2003;21:1180-9
  • Rietveld L, Nieboer TE, Kluivers KB, et al. First case of juvenile granulosa cell tumor in an adult with Ollier disease. Int J Gynecol Pathol 2009;28:464-7
  • Young RH, Dickersin GR, Scully RE. Juvenile granulosa clinicopathological analysis of 125 cases. Am J Surg Pathol 1984;8:575-96 of the ovary. A
  • Kurihara S, Hirakawa T, Amada S, Ariyosh K, Nakano H. Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literatüre. J Obstet Gynaecol Res 2004;30:439-43
  • Healy DL, Burger HG, Mamers P, et al. Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors. N Engl J Med 1993;329:1539-42
  • Zanagnolo V, Pasinetti B, Sartori E. Clinical review of 63 cases of sex cord stromal tumors. Eur J Gynaecol Oncol 2004;25:431-8
  • Zaloudek C, Norris HJ: Granulosa tumors of the ovary in children. Am J Surg Pathol 1982;6:503-12.
  • Vassal G, Flamant F, Caillaud JM, Demeocq F, Nihoul-Fekete le granulosa cell tumor ofthe ovary in children:a clini cal study of 15 cases. J Clin Oncol 1988;6:990-5
  • Schneider DT, Calaminus G, Wessalowski
  • R, Pathmanathan R, Harms D, Göbel U. The
  • rapy of advanced ovarian juvenile granulosa cell tu
  • mors. Klin Padiatr 2002;214:173-8
  • Hirakawa M, Nagai Y, Yagi C, Nashiro T, Inamine M, Aoki Y. Recurrent juvenile granulosa cell tumor of the ovary managed by palliative radiotherapy. Int J Gynecol Cancer 2008;18:913-5
  • Erdreich-Epstein A, Monforte HL, Lavey RS, Joshi S, Phillips multimodality therapy ofrecurrentmultifocal juvenile granulosa cell tumor of the ovary. J Pediatr Hematol Oncol 2002;24:229-33 JG. Successful
Acta Oncologica Turcica-Cover
  • ISSN: 0304-596X
  • Başlangıç: 2015
  • Yayıncı: Dr. Abdurrahman Yurtaslan Ankara Onkoloji EAH