Neslihan Büşra ÖZEROL, Nasibe Aycan YILMAZ, Emre BODRUMLU

Diş hekimliğinde Emdogain

Bir mine matriks türevi olan Emdogain (EMD), dişi destekleyen dokuların rejenerasyonunda klinik olarak kullanılan bir materyaldir. EMD, yüzey detoksifikasyonu, demineralizasyonu ve kollajen liflerin açığa çıkması ve biyouyumlu bir yüzey oluşturulmasını sağlamaktadır. EMD, alkalin fosfataz aktivitesini ve osteoblastlardaki kemik matriks proteinlerinin salınımını arttırmaktadır. Amelogeninler mezenşimal hücreleri stimüle ederek iyileşme, büyüme ve rejenerasyon için gerekli olan faktörlerin açığa çıkmalarını sağlamaktadır. Amelogenin içerikli emdogainin endodontide, periodontolojide, implantolojide ve travmatolojide kemik ve yara iyileşmesi ve vital pulpa tedavilerinde kullanılarak doku rejenerasyonlarında alternatif bir uygulama metodu olduğu görülmüştür.

Anahtar Kelimeler:

Amelin, Amelogenin, Emdogain, Kalsiyum Hidroksit, Mine Matriks Proteinleri, Rejenerasyon

Emdogain in dentistry

Emdogain (EMD) is an enamel matrix derivate and is used clinically for the regeneration of tissues supporting the tooth. EMD provides surface detoxification, demineralization and release of collagen fibers and prepares a biocompatible surface. EMD reinforces the alkaline phosphatase activity and increases release of bone matrix proteins from osteoblasts. Amelogenins, by effecting mesenchymal cells, stimulate the release of factors essential for healing, growth and regeneration. Amelogenin–containing Emdogain can be used in endodontology, periodontology, implantology or traumatology for vital pulp therapy or bone or wound healing purposes; and these applications have been found to be useful alternatives in tissue regeneration.

Keywords:

Amelin, Amelogenin, Calcium Hydroxide, Emdogain, Enamel Matrix Proteins, Regeneration,

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