Ece ÖZDEMİR ÖKTEM, Kübra SOĞUKKANLI, Tansel ÇAKIR, Ahmet ÖZŞİMŞEK, Şeyda ÇANKAYA, Lütfü HANOĞLU

Saf Alzheimer Demansı ile Epileptik Alzheimer Demansı Hastaları Arasındaki Faklı Metabolik ve Klinik Profiller: Metabolik bir çalışma

Amaç: Epileptik Alzheimer hastalarının klinik özelliklerini ve serebral FDG PET metabolizmalarını araştırmak ve saf Alzheimer demansı hastaları ile arasındaki farkları karşılaştırmaktır.Yöntemler: Bu vaka-kontrol çalışmasına Alzheimer hastalığı olan 7 hastadan oluşan control grubu ve Alzheimer hastalığına eşlik eden epilepsisi olan 7 hastadan oluşan çalışma grubu olmak üzere toplam 14 hasta dahil edildi. Tüm katılımcılara ayrıntılı nörobilişsel bateri ve beyin florodeoksiglukoz pozitron emisyon tomografisi (FDG PET-CT) uygulandı.Bulgular: Nörobilişsel test puanları karşılaştırıldığında, çalışma ve kontrol grupları arasında anlamlı bir fark yoktu. Ancak geriatrik depresyon ölçeği puanları çalışma grubunda kontrollere göre anlamlı derecede düşüktü (p= 0.026). Çalışma grubundaki olguların serebral FDG-PET BT profillerinde sol ve sağ serebellum, sol lentiform nükleus, sağ talamus ve vermiste anlamlı düzeyde daha düşük metabolizma saptadık (p=0,008, p=0,023, p=0,003, p=0,002, p =0,002, sırasıyla). Sağ parietotemporal korteks ve sağ ve sol birleştirici görsel kortekste, çalışma grubunda kontrollere göre daha yüksek metabolizma bulduk (sırasıyla p=0.023, p=0.012, p=0.003).Sonuç: Alzheimer demansı olan epileptik hastalar, saf Alzheimer hastalarından farklı klinik ve metabolik profile sahip olabilir. Hastaların nörokognitif klinik skorlarında fark olmasa bile depresyon ve ilişkili fonksiyonel anormallikler epileptik AD hastaları için bir biyobelirteç olabilir.

Anahtar Kelimeler:

Alzheimer hastalığı, epilepsi, FDG-PET BT, metabolizma, depresyon

Different metabolic and clinical profiles between patients with pure Alzheimer dementia and epileptic Alzheimer dementia: a metabolic study

Aim: To investigate the clinical characteristics and cerebral FDG PET metabolisms of dementia patients who were also diagnosed with epilepsy and compare the differences with pure Alzheimer dementia patients.

Keywords:

Alzheimer disease, epilepsy, FDG-PET CT, metabolism, depression,

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