Yıl 2019, Cilt: 2 Sayı : 2 Sayfalar 100 - 112 2019-12-26
Bioapigyn® Ointment of Pelvic Muscle Tonus Versus Pelvic Floor Muscle Training for the Treatment of Urinary Incontinence
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Öz Objective/Purpose: The purpose of this work was the assessment of the clinical efficacy and safety of Bioapigyn® vaginal ointment for pelvic muscle tonus compared to pelvic floor muscle training in alleviating the symptoms of stress, urge and mixed urinary incontinence and vulvo-vaginal disorders in child-bearing and menopausal & postmenopausal women. Materials and Methods: The experimental group consisted of 66 women was treated 28 days with Bioapigyn® ointment for pelvic muscle tonus (2.5 mL/day). The control group also consisted of 66  participants was subjected to pelvic floor muscle training during 28 days (five times a day). ICIQ-UI SF score, the residual urine volume, perineometry, the total score of vulvo-vaginal symptoms and vaginal pH were determined before and after the treatment or training. Results: Following the treatment with Bioapigyn® ointment ICIQ-UI-SF score decreased 54.9%, perineometry parameters  increased  between  31.5  and  34.3%,  residual  urine  decreased  for 76.9%  and  vaginal  pH  for 14.2%. All the symptoms of vulvo-vaginal disorders disappeared completely in all participants. The control group showed no changes in vaginal pH or the improvement concerning the vulvo-vaginal complaints. ICIQ- UI-SF score decreased for 4.3%, residual urine volume for 9.1% while perineometry parameters increased between 4.3 and 8.3%. Conclusion/Discussion: Bioapigyn® vaginal ointment for pelvic muscle tonus alleviate the symptoms of incontinence by tightening and firming of the smooth muscles of the pelvic floor thanks to the ingredients with smooth muscles contraction/relaxation and astringent properties. Low pH, high osmolarity, viscosity, greasiness and coating effect of the ointment eradicated vulvo-vaginal complaints. 

Anahtar Kelimeler

urinary incontinence, vulvo-vaginal disorders, Honey, Herbal Macerates
1. Al-Snafi, A.E., 2015. The chemical constituents and pharmacological effects of Capsella bursa-pastoris-A review. International Journal of Pharmacology and toxicology, 5(2), 76-81.2. Aoki, Y., Brown, H.W., Brubaker, L., Cornu, J.N., Daly, J.O., Cartwright, R., 2018. Urinary incontinence in women, Nature Reviews Disease Primers, 3, 17042. doi:10.1038/nrdp.2017.42.3. Brown, J.S., Grady, D., Ouslander, J.G., Herzog, A.R., Varner, R.E., Posner, S.F., 1999. Prevalence of Urinary Incontinence and Associated Risk Factors in Postmenopausal Women. Obstetrics & Gynecology, 94(1), 66–70.4. Buchsbaum, G.M., Chin, M., Glantz, C., Guzick, D., 2002. Prevalence of Urinary Incontinence and Associated Risk Factors in a Cohort of Nuns. Obstetrics & Gynecology, 100(2), 226–229.5. Danforth, K.N., Townsend, M.K., Lifford, K., Curhan, G.C., Resnick, N.M., Grodstein, F., 2006. Risk factors for urinary incontinence among middle-aged women. American Journal of Obstetrics and Gynecology, 194, 339–345.6. Grosso, C., Vinholes, J., Silva, L.R., Guedes de PinhoI, P., Gonçalves, R.F., Valentão P., JägerII A.K., Andrade P.B., 2011. Chemical composition and biological screening of Capsella bursa-pastoris. Brazilian Journal of Pharmacognosy, 21(4), 635-644.7. Khandelwal, C., Kistler, C., 2013. Diagnosis of Urinary Incontinence. American Family Physician, 87(8),543-550.8. Luber, K. M., 2004. The Definition, Prevalence, and Risk Factors for Stress Urinary Incontinence. Reviews in urology, 6(3), 3-9. 9. McPhil, J. H., 2004. The prevalence of stress urinary incontinence in women. Nursing time, 100(20), p.70.10. Minassian, V.A., Stewart, W.F., Wood, G.C., 2008. Urinary Incontinence in Women: Variation in Prevalence Estimates and Risk Factors. Obstetrics & Gynecology, 111(2), 324-331.11. Minassian, V.A., Drutz, H.P., Al-Badr, A., 2003. Urinary incontinence as worldwide problem. International Journal of Gynecology and Obstetrics, 82, 327–338.12. Nygaard, IE., Heit, M., 2004. Stress Urinary Incontinence. Obstetrics & Gynecology, 104(3), 607-620.13. Oreščanin, V., Findri Guštek, Š., 2016. Development and Testing of New Herbal Ointment for the Treatment of Stress Urinary Incontinence-A Preliminary Study. Global Journal For Research Analysis, 5(7), 371-374.14. Oreščanin, V., Findri Guštek, Š. Fistonić, I., Rodić, J., 2018. Efficacy of bioapigyn ointment for pelvic muscle tonus in the treatment of stress urinary incontinence and vulvo-vagnal disorders. IJRDO - Journal of Health Sciences And Nursing, 3(10), 13-25.15. Peyrat, L., Haillot, O., Bruyere, F., Boutin, J.M., Bertrand, P., Lanson, Y., 2002. Prevalence and risk factors of urinary incontinence in young and middle-aged women. BJU International, 89(1), 61–66. 16. Radzimińska, A., Strączyńska, A., Weber-Rajek, M., Styczyńska, H., Strojek, K., Piekorz. Z., 2018. The impact of pelvic floor muscle training on the quality of life of women with urinary incontinence: a systematic literature review. Clinical Interventions in Aging, 13, 957–965.17. Rovner, S.E., Wein, J.A., 2004. Treatment Options for Stress Urinary Incontinence. Reviews in urology, 6 (Suppl 3), S29–S47.18. Zhu, L., Lang, J., Liu, C., Han, S., Huang, J., Li, X., 2009. The epidemiological study of women with urinary incontinence and risk factors for stress urinary incontinence in China. Menopause, 16(4), 831-836.
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Yayımlanma Tarihi 26 Aralık 2019
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Yayımlanma Tarihi : 26 Aralık 2019

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