Yıl 2019, Cilt: 2 Sayı : 2 Sayfalar 83 - 92 2019-12-26
The Determination of the Effects of Wild Thyme (Thymbra spicata L.) and Cumin (Cuminum cyminum L.) Extracts on SCE (Sister Chromatid Exchange) in Human Lymphocyte Chromosomes
Hanife ARDAHANLI,Süleyman GÜL
20 261

Öz The purpose of this work is to determine of T. spicata L. and C. cyminum L. plant extracts on sister chromatid exchange rate in human peripheral lymphocyte culture as in vitro. Human blood lymphocyte cells, T. spicata L. and C. cyminum L. plant extracts were allowed to interact with doses of 0.05 µL/mL, 0.10 µL/mL, 0.15 µL/mL and 0.20 µL/mL for 24 hours. When trial groups where plant extracts were applied were compared with negative control and mitomycin-C (MMC) which was used as positive control, it was determined that the extract doses applied led to an increase in sister chromatid exchange rate. Also, it was found that increasing concentrations of plant extracts caused cell replication index to decrease. Between C. cyminum L. doses and RI, a negative correlation (r = -0.95) was observed and between T. spicata L. doses and RI a negative correlation was observed (r = -0.94) respectively. As a result of this study; T. spicata L. and C. cyminum L. plant extracts were found to have genotoxic and clastogenic effects on human peripheral lymphocytes.

Anahtar Kelimeler

Mitomycin-C, Replication Index, Genotoxic, Clastogenic
REFERENCES1. Aydın, Ö., 2011. ‘Tarçın, Kimyon Ve Sumak Adlı Baharat Türlerinden Elde Edilen Su, Etanol-Su, Metanol ve Kloroform Ekstraktlarının In Vitro Antioksidan Özelliklerinin Belirlenmesi’ Atatürk University, Institute of Health Sciences, Pharmacy-Biochemistry Department, Erzurum.
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Konular Biyoloji
Yayımlanma Tarihi 26 Aralık 2019
Bölüm Articles
Yazarlar Orcid : 0000-0002-0754-8699Yazar: Hanife ARDAHANLI (Sorumlu Yazar)Kurum: kafkas üniversitesiÜlke: Turkey

Orcid : 0000-0002-1568-5909Yazar: Süleyman GÜL Kurum: kafkas üniversitesiÜlke: Turkey

Tarihler

Yayımlanma Tarihi : 26 Aralık 2019


Makalenin Yazarları
Hanife ARDAHANLI
Süleyman GÜL