TAURIN KIRIK İYİLEŞMESİNİ ETKİLER Mİ? DENEYSEL BİR ÇALIŞMA
DOI: 10.26650/IUITFD.394531Amaç: Yapısal olmayan bir amino asit olan
antioksidan etkili taurinin kırık iyileşmesi üzerine etkilerinin araştırılmasıGereç ve Yöntem: Kontrol grubunda dokuz,
taurin grubunda yedi tane Yeni Zelanda tipi tavşana açık tibial osteotomi
uygulandı. Radyolojik kırık iyileşmesi, 21. günde çekilen direk grafi ve
bilgisayarlı tomografi (BT) kesitleri üzerinde Goldberg skoru ile
değerlendirildi. Histoloik olarak iyileşme Huo skoruna göre derecelendirildi.
Sıfırıncı, yedinci, 14. ve 21. günlerde serumda malondialdehit (MDA) ve alkalen
fosfataz (ALP) düzeyleri ölçüldü. Bulgular: Direk grafi ve BT kesitlerine
göre kırık iyileşmesinin ortanca evresi taurin grubunda radyolojik kaynamayken
kontrol grubunda olası kaynama olarak bulundu. Histolojik olarak, kallus taurin
grubunda esas olarak kemik dokusundan oluşurken (ortanca Huo skoru 8), kontrol
grubunda baskın doku kıkırdaktı (ortanca Huo skoru 6). MDA düzeyindeki
değişimler oksidatif stresin kırık iyileşmesinin enflamatuvar fazında en yüksek
olduğunu göstermekteydi. Her iki grupta da ALP düzeyleri önce azalmış, 21.
Günde yeni kemik oluşumuyla yeniden yükselmiş olarak bulundu.
Sonuç:
Bu çalışmanın sonuçları deneysel osteotomi modelinde taurinin erken evre
kırık iyileşmesi üzerinde olumlu etkileri olduğunu desteklemektedir. Bu etki
tarunin antioksidan özelliği ile ilişkilendirilebilir.
Anahtar Kelimeler:
Taurin, kırık iyileşmesi, oksidatif stres, antioksidan, malondialdehit (MDA)
DOES TAURINE IMPROVE FRACTURE HEALING? AN EXPERIMENTAL STUDY
DOI: 10.26650/IUITFD.394531Objective: To evaluate the influence of
taurine, a non-structural amino acid with antioxidant effects, on fracture
healing.Materials and Methods: Open tibial
osteotomy was performed on nine New Zealand rabbits in the control group and
seven in the taurine group. Radiologic fracture healing was assesed using the
Goldberg score on x-rays and computed tomography (CT) sections on the 21st day.
Healing was graded histologically using the Huo score. Serum malondialdehyde
(MDA) and alkaline phosphatase (ALP) levels were measured, at days zero, seven,
14 and 21. Results: Upon completion of the study, in
the taurine group, the median stage of healing was recorded as “radiologic
union”, whereas it was “probable union” in the control group with respect to
x-ray and CT sections. In the taurine group, callus was mainly composed of
osteoid tissue (median Huo score 8); in the control group the predominant
tissue was chondroid (median Huo score 6). Changes in MDA levels revealed that
oxidative stress was greatest in the inflammatory phase. In both groups, the
ALP levels first decreased, and then increased ,with new bone formation on the
21st day.
Conclusion: Taurine improved early bone
healing in an experimental animal osteotomy model. This influence might be
related to its antioxidant properties.
Keywords:
Taurine, fracture healing, oxidative stress, antioxidants, malondialdehyde (MDA),
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- Başlangıç: 1916
- Yayıncı: İstanbul Üniversitesi Yayınevi
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