Yıl 2020, Cilt: 50 Sayı : 1 Sayfalar 54 - 59 2020-04-01
Studies on the formulation optimization and controlled ionic gelation of chitosan nanoparticles using TPP-HP-β-CD inclusion complex
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Öz Background and Aims: Ionic gelation strategy is the most common method used for the preparation of chitosan nanoparticles to obtain controlled drug delivery. Although it is a convenient and easy method, it is highly related with particle aggregation, high polidispersity index and insufficient physical/chemical stability. The aim of this study was the development of chitosan nanoparticles using tripolyphosphate-hydroxy propyl β-cyclodextrin or tripolyphosphate-sulfobutyl ether β-cyclodextrin inclusion complex as an alternative to TPP, and hence to increase physical stability, reduce polidispersity index and develop a stable nanocarrier for drug delivery purposes. Methods: The nanoparticles were prepared with the ionic gelation technique. The effects of chitosan percent, pH, and chitosan/tripolyphosphate ratio were investigated to find out the optimum nanoparticles in terms of particle size, polidispersity index and zeta potential. After determining the conditions for the tripolyphosphate-chitosan nanoparticles, the nanoparticles were prepared using tripolyphosphate-hydroxypropyl β-cyclodextrin or tripolyphosphate-sulfobutyl ether β-cyclodextrin to make a comparison with the nanoparticles which were prepared using tripolyphosphate. Results: The chitosan/tripolyphosphate-hydroxypropyl β-cyclodextrin nanoparticles were successfully formulated with 178 ± 84.1 nm particle size, 0.310±0.0134 PDI, 31.2±4.68 mV zeta potential. The interday changes in the measured characteristics were minimized for chitosan/tripolyphosphate-hydroxypropyl β-cyclodextrin nanoparticles as intended. Conclusion: CS/TPP-HP-β-CD nanoparticle formulation with particle size below 200 nm, high zeta potential and increased physical stability nanoparticles would offer a promising approach especially for hydrophobic drugs to improve their stability, solubility, encapsulation efficiency and in vivo bioavailability.

Anahtar Kelimeler

Chitosan nanoparticles, controlled ionic gelation, cyclodextrins
• Ağardan, N. B., Değim, Z., Yılmaz, Ş., Altıntaş, L., & Topal, T. (2016). The Effectiveness of raloxifene-loaded liposomes and cochleates in breast cancer therapy. AAPS PharmSciTech, 17(4), 968– 977.
Birincil Dil en
Konular Farmakoloji ve Eczacılık, Sağlık Bilimleri ve Hizmetleri
Yayımlanma Tarihi 1 Nisan 2020
Bölüm Original Article
Yazarlar Orcid : 0000-0002-4882-3124Yazar: N. Başaran MUTLU AĞARDAN Kurum: GAZİ ÜNİVERSİTESİÜlke: Turkey


Yayımlanma Tarihi : 1 Nisan 2020

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