İntrahepatik kolestazlı gebelerde maternal ve fetal sonuçların değerlendirilmesi

Amaç:Bu çalışmada kliniğimizde gebeliğin intrahepatik kolestazı(GİK) tanısı konmuş gebelerin maternal ve fetal sonuçlarıdeğerlendirildi. Yöntem ve gereçler:Bu çalışma retrospektif olarak tasarlanmış olup, Eylül 2017 ve Eylül 2018 tarihleri arasındaBursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniğine başvuran toplam 53 hastayla yapıldı.GİK tanısı kaşıntı ve karaciğer enzimleri ile açlık safra asit düzeylerinde artış(≥10 µmol/L) artış olması durumunda konuldu.Hastaların hastane kayıtlarından doğum bilgileri ve demografik özelliklerine ulaşıldı. Bulgular:Çalışmaya alınan hastaların yaş ortalaması 30.5±5.7 yıl ve tanı anındaki gebelik yaşı ortalaması 32.3±2.8 hafta olarak saptandı. Ortalama safra asit düzeyi 26.42±19.1 µmol/Lolarak hesaplandı.Hastaların %26.4’ünde gestasyonel diyabet, %15.1’inde preeklampsi görüldü.Hastaların %37.7’sinin preterm doğum yaptığı tespit edildi.Yenidoğan bebeklerin %32.7’si yenidoğan yoğun bakım ünitesine alınırken, %32.7’sinde yenidoğan geçici taşipnesi, %33.3’ünde respiratuvar distres sendromu geliştiği görüldü.Perinatal mortalite ise saptanmadı. Sonuç:Çalışma sonuçlarımıza göre, GİK takibinde en önemli unsurlar olan perinatal mortalite ve morbiditeyi azaltmak için hastaların yakın takibi ve şiddetli kolestaz bulguları olan hastaların belirlenip uygun tedavinin erken başlanması oldukça önemlidir.

Anahtar Kelimeler:

gebelik, intrahepatik kolestaz

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