Yeşim AKDEMİR, Görker SEL, Büşra AYNALI, Mehmet İbrahim HARMA

Endometriyal biopsi işlemi öncesinde kullanılan oral Hyosine N Butil Bromur’ün analjezik etkinliği

Amaç: Bu çalışmanın amacı Pipelle ile yapılan endometrial biyopsi işlemi öncesinde oral yoldan alınan 10 mg Hyosine N Butil Bromur (HBB)’nin analjezik etkinliğini değerlendirmektir.Gerek ve Yöntem: Eylül 2018- Eylül 2019 tarihleri arasında, xxxxxxxxxxxxx, anormal uterin kanamanın değerlendirilmesi için Pipelle ile endometriyal biyopsi yapılmış, 18-49 yaş arasındaki hastaların dosyaları retrospektif olarak incelendi. Endometriyal biyopsi işleminin 30 dakika öncesinde oral yoldan 10 mg HBB kullanan 48 hasta HBB Grubu, endometriyal biyopsi işlemi öncesinde hiçbir analjezik kullanmayan 56 hasta ise Kontrol Grubu olarak ayrıldı.Bulgular: Yaş, vücut kitle indeksi, parite, vajinal ve sezaryen doğum sayısı, nulliparite, multiparite ve menopozal durum parametreleri açısından 2 grup arasında fark gözükmezken endometriyal biyopsinin hemen sonrasında kaydedilmiş VAS (0) ve endometriyal biyopsiden 30 dakika sonra kaydedilmiş olan VAS (30) skorları HBB Grubunda Kontrol Grubuna göre daha düşük saptandı (sırasıyla 59,3 ± 21,12 vs 86,42 ± 10.95, ve 19,09 ± 23,85 vs 55,71 ± 21,67; p≤0,001) Sonuç: Endometriyal biyopsi işleminden 30 dakika önce oral yoldan alınan 10 mg HBB’nin, endometriyal biyopsi sırasında ve işlemden 30 dakika sonrasında analjezik etkinliği vardır. Bu data HBB’nin diğer jinekolojik endikasyonlar ile kullanımının yaygınlaşmasına yardımcı olabilir.

Anahtar Kelimeler:

Ağrı, Hyosine N Butil Bromur, Pipelle, endometriyal biyopsi

Analgesic effect of oral Hyoscine N Butyl Bromur in endometrial biopsy

Objective: To investigate the efficacy of oral 10 mg Hyoscine N Butyl Bromur (HBB) on pain perception of the patients who underwent endometrial biopsy with Pipelle.Material and Method: The charts of the patients who were 18-49 years and underwent endometrial biopsy with Pipelle for evaluation of abnormal uterine bleeding at xxxxxxxxxxxxxxxxxxxxxxxxxxxxx between September 2018 and September 2019 were retrospectively evaluated. 48 patients were seperated as HBB Group who used oral 10 mg HBB 30 minutes before endometrial biopsy and 56 patients as Control Group who did not used any pain relief medication before endometrial biopsy. Results: There were no statistically significant difference between two groups in age, BMI, parity, number of vaginal and cesarean births, nulliparity, multipartiy, and menopausal status. On the other hand, VAS (0) scores which were recorded immediately after endometrial biopsy and VAS (30) scores which were recorded 30 minutes after endometrial biopsy of the patients of the HBB Group were lower than the Control Group (59,3 ± 21,12 vs 86,42 ± 10.95, ve 19,09 ± 23,85 vs 55,71 ± 21,67 respectively; p≤0,001). Conclusion: 10 mg oral HBB when taken 30 minutes before intervention, significantly decreases pain associated with Pipelle endometrial biopsy. This data might help to increase the endication spectrum of HBB for analgesic purposes in gynecology field.

Keywords:

Endometrial biopsy, Hyoscine N Butyl Bromur, pain, pipelle,

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