Objective: The aim of this study was to evaluate the clinicopathological features and oncologic outcomes in patients with struma ovarii (SO) treated and followed up in our hospital. Material and Methods: The presented study included 14 patients diagnosed with SO in a single institution for a period of 25 years. Results: Histopathological diagnosis revealed benign SO in 13 patients and follicular carcinoma in 1 patient with malignant transformation in final pathology reports. The patient with malignant SO was follicular type and stage Ic2. This patient did not receive adjuvant therapy. The median follow-up time of the study cohort was 31 months and ranged between 3 and 134 months. No recurrence was detected in the patient with malignant SO during 44 months of follow-up. Conclusion: Surgical intervention is adequate for treatment in patients with benign SO. For patients with malignant transformation, a conservative surgery may be suitable for fertility sparing. Additionally, staging surgery including retroperitoneal lymph node dissection is recommended for determining adjuvant therapy decisions. Due to the absence of well-defined and precise guidelines for treatment, a multidisciplinary approach is suitable for patients with malignant SO. Therapy modalities should be individualized according to intraoperative and postoperative findings in this patient group. "> [PDF] Struma ovarii: Analysis of a single institution | [PDF] Struma ovarii: Analysis of a single institution Objective: The aim of this study was to evaluate the clinicopathological features and oncologic outcomes in patients with struma ovarii (SO) treated and followed up in our hospital. Material and Methods: The presented study included 14 patients diagnosed with SO in a single institution for a period of 25 years. Results: Histopathological diagnosis revealed benign SO in 13 patients and follicular carcinoma in 1 patient with malignant transformation in final pathology reports. The patient with malignant SO was follicular type and stage Ic2. This patient did not receive adjuvant therapy. The median follow-up time of the study cohort was 31 months and ranged between 3 and 134 months. No recurrence was detected in the patient with malignant SO during 44 months of follow-up. Conclusion: Surgical intervention is adequate for treatment in patients with benign SO. For patients with malignant transformation, a conservative surgery may be suitable for fertility sparing. Additionally, staging surgery including retroperitoneal lymph node dissection is recommended for determining adjuvant therapy decisions. Due to the absence of well-defined and precise guidelines for treatment, a multidisciplinary approach is suitable for patients with malignant SO. Therapy modalities should be individualized according to intraoperative and postoperative findings in this patient group. ">

Struma ovarii: Analysis of a single institution

Struma ovarii: Analysis of a single institution

Objective: The aim of this study was to evaluate the clinicopathological features and oncologic outcomes in patients with struma ovarii (SO) treated and followed up in our hospital. Material and Methods: The presented study included 14 patients diagnosed with SO in a single institution for a period of 25 years. Results: Histopathological diagnosis revealed benign SO in 13 patients and follicular carcinoma in 1 patient with malignant transformation in final pathology reports. The patient with malignant SO was follicular type and stage Ic2. This patient did not receive adjuvant therapy. The median follow-up time of the study cohort was 31 months and ranged between 3 and 134 months. No recurrence was detected in the patient with malignant SO during 44 months of follow-up. Conclusion: Surgical intervention is adequate for treatment in patients with benign SO. For patients with malignant transformation, a conservative surgery may be suitable for fertility sparing. Additionally, staging surgery including retroperitoneal lymph node dissection is recommended for determining adjuvant therapy decisions. Due to the absence of well-defined and precise guidelines for treatment, a multidisciplinary approach is suitable for patients with malignant SO. Therapy modalities should be individualized according to intraoperative and postoperative findings in this patient group.

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  • 1. Roth LM, Talerman A. The enigma of struma ovarii. Pathology 2007;39:139–46.
  • 2. Yoo SC, Chang KH, Lyu MO, Chang SJ, Ryu HS, Kim HS. Clinical characteristics of struma ovarii. J Gynecol Oncol 2008;19:135–8.
  • 3. Pick L. Beitrag zur Lehre von den Greschwülsten über struma thyroidaea ovarii aberrata. Verhandlungen der Berliner Medizinischen Geselschaft 1903;33:139–46. [Article in German]
  • 4. Hinshaw HD, Smith AL, Desouki MM, Olawaiye AB. Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma, and strumal carcinoid: A case report and literature review. Case Rep Obstet Gynecol 2012;2012:269489.
  • 5. DeSimone CP, Lele SM, Modesitt SC. Malignant struma ovarii: A case report and analysis of cases reported in the literature with focus on survival and I131 therapy. Gynecol Oncol 2003;89:543–8.
  • 6. Marti JL, Clark VE, Harper H, Chhieng DC, Sosa JA, Roman SA. Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: A series of 4 patients and a review of 53 reported cases. Thyroid 2012;22:400–6.
  • 7. Sternlieb SJ, Satija C, Pointer DT Jr, Crawford BE, Sullivan L, Kandil E. Management dilemma of thyroid nodules in patients with malignant struma ovarii. Gland Surg 2016;5:431–4.
  • 8. Dardik RB, Dardik M, Westra W, Montz FJ. Malignant struma ovarii: Two case reports and a review of the literature. Gynecol Oncol 1999;73:447–51.
  • 9. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. World Health Organization classification of tumours of female reproductive organs. 4th ed. Lyon: IARC; 2014.
  • 10. Lara C, Cuenca D, Salame L, Padilla-Longoria R, Mercado M. A Hormonally active malignant struma ovarii. Case Rep Oncol Med 2016;2016:2643470.
  • 11. Roth LM, Miller AW 3rd, Talerman A. Typical thyroid-type carcinoma arising in struma ovarii: A report of 4 cases and review of the literature. Int J Gynecol Pathol 2008;27:496–506.
  • 12. Iranparvar Alamdari M, Habibzadeh A, Pakrouy H, Chaichi P, Sheidaei S. An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report. Int J Surg Case Rep 2018;51:218–20.
  • 13. Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA. Malignant struma ovarii: A population-level analysis of a large series of 68 patients. Thyroid 2015;25:211–5.
  • 14. Yassa L, Sadow P, Marqusee E. Malignant struma ovarii. Nat Clin Pract Endocrinol Metab 2008;4:469–72.
  • 15. Fujiwara S, Tsuyoshi H, Nishimura T, Takahashi N, Yoshida Y. Precise preoperative diagnosis of struma ovarii with pseudo-Meigs’ syndrome mimicking ovarian cancer with the combination of 131I scintigraphy and 18F-FDG PET: Case report and review of the literature. J Ovarian Res 2018;11:11.
  • 16. Matsuda K, Maehama T, Kanazawa K. Malignant struma ovarii with thyrotoxicosis. Gynecol Oncol 2001;82:575–7.
  • 17. Devaney K, Snyder R, Norris HJ, Tavassoli FA. Proliferative and histologically malignant struma ovarii: A clinicopathologic study of 54 cases. Int J Gynecol Pathol 1993;12:333–43.
  • 18. Robboy SJ, Shaco-Levy R, Peng RY, Snyder MJ, Donahue J, Bentley RC, et al. Malignant struma ovarii: An analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol 2009;28:405–22.
  • 19. McGill JF, Sturgeon C, Angelos P. Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation. Endocr Pract 2009;15:167– 73.
  • 20. Siegel MR, Wolsky RJ, Alvarez EA, Mengesha BM. Struma ovarii with atypical features and synchronous primary thyroid cancer: A case report and review of the literature. Arch Gynecol Obstet 2019;300:1693–707.
  • 21. Williams H, Salinas E, Savage E, Samuelson M, Goodheart MJ. Malignant struma ovarii with insular carcinoma: A case report and literature review. Gynecol Oncol Rep 2016;18:1–3.
  • 22. Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S. Poorly differentiated thyroid carcinoma arising in struma ovarii. Case Rep Pathol 2015;2015:826978.
  • 23. Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan et al. Malignant struma ovarii: From case to analysis. J Obstet Gynaecol Res 2021;47:3339–51.
  • 24. Zhu Y, Wang C, Zhang GN, Shi Y, Xu SQ, Jia SJ, et al. Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: A case report and review of the literature. World J Surg Oncol 2016;14:17.
  • 25. Shaco-Levy R, Peng RY, Snyder MJ, Osmond GW, Veras E, Bean SM, et al. Malignant struma ovarii: A blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. Arch Pathol Lab Med 2012;136:172–8.
  • 26. Luo JR, Xie CB, Li ZH. Treatment for malignant struma ovarii in the eyes of thyroid surgeons: A case report and study of Chinese cases reported in the literature. Medicine (Baltimore) 2014;93:e147.
  • 27. Zhang X, Axiotis C. Thyroid-type carcinoma of struma ovarii. Arch Pathol Lab Med 2010;134:786–91.
Zeynep Kamil medical journal (Online)-Cover
  • ISSN: 1300-7971
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Ali Cangül
Sayıdaki Diğer Makaleler

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