Prostat Kanseri Tanısında Kan Nötrofil / Lenfosit Dağılımının Yeri

Amaç: Nötrofil lenfosit oranı (NLR) son zamanlarda oldukça popüler olan tanısal bir belirteçtir. Bu makalede NLR’nin prostat kanseri tanısındaki yeri, cut off değeri yanında platelet lenfosit oranı (PLR), Gleason skoru ve biyopside saptanan tümör yüzdesi ile ilişkisi değerlendirildi. Ayrıca transrektal ultrason (TRUS) eşliğinde biyopsi yapılan hastaların bulguları paylaşıldı.Gereç ve Yöntemler: Kliniğimizde 2014 ağustos – 2017 şubat tarihlerinde, prostat spesifik antijen (PSA) değerleri 2.5ng/ml ve üzeri olup TRUS eşliğinde prostat biyopsisi yapılan 679 hastanın sonuçları retrospektif olarak incelendi. Hastalar PSA değerlerine göre 2.5-3.9 ng/ml arası (Grup 1), 4-9.9 ng/ml arası (Grup 2), 10-19.9 ng/ml arası (Grup 3), 20 ng/ml ve üzeri (Grup 4) olarak dört gruba ayrıldı. NLR’nin bu gruplarda patoloji sonuçlarına göre tanısal değeri incelendi. Bulgular: NLR, grup 2,3 ve 4’te diagnostik bir belirteç olarak bulundu. Cut off değeri 2.5 olarak hesaplandı. PLR ile benzer tanısal güce sahipti. Gleason skoru ve her bir core tümör yüzdesi ile zayıf bir korelasyonu vardı. Kemik metastazını öngörmede bir öneme sahip değildi. PSA dansitesi ve rektal tuşe bulguları arasındaki fark, patolojisi prostat kanseri (PCa) veya benign prostat hiperplazisi (BPH) olan gruplar da istatistiksel olarak anlamlıydı.Sonuç: NLR PCa tanısında çok güçlü olmasa da diagnostik bir değere sahiptir. PSA’ yı destekleyici bir belirteç olarak kullanılabilir.   

The Role Of Blood Neutrophil / Lymphocyte Distribution in The Diagnosis Of Prostate Cancer

Objective: Neutrophil to lymphocyte ratio (NLR) is a recently popular diagnostic marker. We sought answers to questions such as whether this marker has a role in the diagnosis of prostate cancer, any cut off value can be calculated, compared to platelet lymphocyte ratio (PLR) and it has a relationship with Gleason score and percentage of tumors detected in biopsy cores. In addition, we aimed to share the findings of patients undergoing transrectal ultrasound (TRUS) guided biopsy.Materials and Methods: The results of 679 patients who underwent TRUS-guided prostate biopsy with prostate specific antigen (PSA) values above 2.5 ng / ml in our clinic between August 2014 and February 2017 were retrospectively analyzed. Patients were between 2.5-3.9 ng / ml (Group 1), 4-9.9 ng / ml (Group 2), 10-19.9 ng / ml (Group 3), 20 ng / ml and above (Group 4) according to PSA values, divided into four groups. The diagnostic value of NLR was evaluated in these groups.Results: NLR was found as a diagnostic marker in groups 2,3 and 4. The cut off value was calculated as 2.5. It had similar diagnostic power as PLR. There was a poor correlation with Gleason score and percentage of tumor in cores. It was not important in predicting bone metastasis. The difference between PSA density and DRE was statistically significant in groups with pathologic prostate cancer (PCa) or benign prostatic hyperplasia (BPH).Conclusion: Although NLR is not very strong in the diagnosis of PCa, it has a diagnostic value. It can be used as a marker to support PSA.

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Yeni Üroloji Dergisi-Cover
  • ISSN: 1305-2489
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2005
  • Yayıncı: Avrasya Üroonkoloji Derneği
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