SEMİH TANGAL, Kutsal ONAL, Ahmet Hakan HALİLOĞLU, Metin YIĞMAN

Nötrofil lenfosit oranının lokalize böbrek tümörlerinde tümör özellikleri ile ilişkisi

Amaç: Nötrofil/Lenfosit oranının birçok ürolojik tümörde prognostik faktör olduğu gösterilmesine karşın lokalize böbrek tümörlerinde tümörün özellikleri ile ilişkisini araştırmayı amaçladık. Gereç ve Yöntemler: Kliniğimizde renal kitle tanısı ile opere edilen 125 hastanın laboratuvar ve patoloji sonuçları geriye dönük olarak incelendi. Tüm hastaların operasyon öncesi yapılan tam kan sayımlarından nötrofil/lenfosit oranı(NLR) tespit edildi. NLR’nin tümörün boyutu, tarafı, lokalizasyonu, histolojik tipi ve Fuhrman derecesi arasındaki ilişki istatistiksel olarak değerlendirildi. Bulgular: Preoperatif hesaplanan NLR ile hastaların cinsiyet ve yaş faktörleri, tümörün tarafı, lokalizasyonu, boyutu ile istatistiksel olarak anlamlı bir ilişki saptanmadı (p>0,05). Ayrıca tümör histopatolojilerine göre benign ve malign olarak, malign tümörlerde ise berrak hücreli olan ve olmayan olarak ikili gruplandırıldıklarında da NLR ile gruplar arasında istatistiksel olarak anlamlı bir ilişki izlenmedi (p>0,05). Berrak hücreli tümör patoloji raporlarından elde edilen Fuhrman dereceleri ile NLR arasında da istatistiksel olarak anlamlı bir sonuç saptanmadı (p>0,05). Sonuç: NLR’nin böbrek tümörlerinde diğer prognostik faktörlerden bağımsız bir değişken olduğu düşünülmesine rağmen literatürdeki farklı sonuçlardan dolayı daha kapsamlı geniş çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Nötrofil lenfosit oranı, böbrek, tümörü

Relation of neutrophil lymphocyte ratio with tumor characteristics in localized kidney tumors

Aim: Considering that neutrophil/lymphocyte ratio is indicated as prognostic factor in many urologic neoplasms, the purpose of this paper is to examine the relation between this ratio and characteristics of tumors in localized kidney tumors. Material and Methods: Laboratory and pathology results of 125 patients operated in our clinic with the diagnosis of renal lump were examined retrospectively. Neutrophil/ lymphocyte ratios (NLR) of all patients were detected by an examination of pre-operation complete blood cell counts. The relations between NLR and size, side, location, histological type and Fuhrman degree of tumor were assessed statistically. Findings: Statistically significant relations could not be detected among preoperative NLR and sex and age of patients and size, side and location of tumor (p<0.05). Also, when tumors were divided into two as benign and malign and malign ones were grouped into two as tumors with and without clear cells, statistically significant relations could not be reported between NLR and these groups (p>0.05). A statistically significant relation could not be found between NLR and Fuhrman degrees obtained from clear cell tumor pathology reports (p>0.05). Conclusion: Although it is thought that NLR is a variable independent from the other prognostic factors in the kidney tumors, more comprehensive studies are needed due to different results available in the literature.

Keywords:

Neutrophil lymphocyte ratio, kidney tumor,

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