Radikal nefrektomi yapılmış lokal veya lokal ileri renal tümörlerde patolojik nekroz ve sarkomatoid varyant birlikteliğinin önemi: Retrospektif değerlendirme

Bu çalışmada, radikal nefrektomi yapılmış lokal veya lokal ileri böbrek tümörlerinde sarkomatoid pattern ve tümör nekrozunun diğer patolojik prognostik parametre-lerle olan ilişkileri değerlendirildi. Kırkbir hasta çalışmaya dahil edildi. Yaş, cinsiyet, semptomlar, üriner ultrason, idrar tetkiki, kreatinin, renal CT ile incelemeler yapıldı. Her hastaya radikal nefrektomi yapıldı. Patolojik spesmenlerde, tümör boyutu, perinefrik yağ, adrenal invazyonu, toplayıcı sistem invazyonu, renal ven tutulumu, Gerota dışı yayılım, lenfadenopati, Fuhrman grade, histolojik subtip, sarkomatoid varyant, patolojik nekroz ışık mikroskobuyla hematoksilen-eozin boyama ile değerlendirildi. İstatistiksel analiz korelasyon ve Spearman�s rho test kullanılarak yapıldı. Ortalama yaş 62,0 (33-81) idi. Hastaların 18�i kadın, 23�ü erkekti. Takip sırasında ölen 2 hasta dışında diğer hastalara rutin kontroller yapıldı. 38 hastada berrak hücreli karsinom, 2 hastada papiller, 1 hastada kromofob subtipler saptandı. 27 (%65,8) hastada tümör nekrozu rapor edildi. İncelemelerde sarkomatoid pattern ile perirenal yağ invazyonu ve Fuhrman grade arasındaki ilişki anlamlı olarak saptandı (p

The importance of coexisting the pathologic necrosis with sarcomatoid variant in local or local progressive renal tumour underwent the radical nephrectomy

In this study, we evaluated association of sarcomatoid variant and necrosis with the other prognostic pathologic parameters in in local or local progressive renal tumour underwent the radical nephrectomy 41 patients, diagnosed with renal tumor, were included. Age, gender, symptoms, urinary ultrasound, urine analyze, creatinine, renal CT, were evaluated. Radical nephrectomy was performed to each patients. In pathologic features of prognosis, size, perinephric adrenal, fat invasion, collecting duct invasion, renal vein invasion, out of Gerota invasion, lymphadenopathy, Fuhrman grade, histologic subtype, sarcomatoid variant, pathologic necrosis, microvascular invasion were examined under the light microscope stained by heamatoxilen-eozin. Spearman&#8217;s rho tests were used for statistical analyze. Mean age was 62.0 (33-81). 18 female, 23 male patients were detected. 2 patients were excluded due to exitus, the others had a regular follow-up. 38 clear cell carcinoma, 2 papillary, 1 chromofob pathologic subtypes were determined. 27 (65.8%) patients had a tumor necrosis in pathologic specimens. In pathologic prognostic factors, the association of sarcomatoid pattern with perirenal fat invasion and Fuhrman grade was confirmed statistically (p<0.01), pathologic necrosis was significantly correlated with tumor size (p<0.01). The other pathologic parameters were insignificant with sarcomatoid pattern and tumor necrosis. Tumor necrosis and sarcomatoid variant may be a valuable independent prognostic factor for local or local progressive renal tumors, and has correlations with tumor size, Fuhrman grade and perinephric fat invasion.

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Yeni Tıp Dergisi-Cover
  • ISSN: 1300-2317
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2018
  • Yayıncı: -
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