Obez ve diyabetik olmayan hastalarda alkol dışı karaciğer yağlanması ile tiroid fonksiyonları arasındaki ilişki

Giriş: Alkol dışı karaciğer yağlanması (ADKY) alkol kullanım hikâyesi olmayan hastalarda, alkole bağlı karaciğer hastalığında gözlenen morfolojik değişiklikler ile karakterizedir. Tiroid hormonları karbonhidrat ve protein metabolizması yanında lipid metabolizmasında da son derece önemli rolü olan hayati hormonlardır. Bu çalışmanın amacı obez ve diyabetik olmayan yağlı karaciğer hastalarında hipotiroidi birlikteliğini saptamaktır. Materyal ve Metot: Nisan 2010 ve Nisan 2011 tarihleri arasında Turgut Özal Üniversitesi Hastanesi İç Hastalıkları ve Gastroenteroloji poliklerine başvuran diyabetik olmayan ve beden kitle indeksleri

The association of thyroid function tests with non-alcoholic fatty liver disease among non-obese and non-diabetic cases

Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by the morphological changes similar to those observed in alcohol related liver disease, in patients without significant alcohol consumption. Thyroid hormones are essential hormones in not only carbohydrate and protein metabolisms, but also in fatty liver oxidation. The aim of this study was to determine the association of hypothyroidism with NAFLD among non-obese and non-diabetic cases. Material and Methods: Totally 1282 non-diabetic, non- obese cases, 970 female, 312 male, admitted to Internal Medicine and Gastroenterology outpatient clinics of Turgut Ozal University Hospital, in between April 2010 and April 2011, were included in the study. Body mass index, liver function tests, lipid profile, thyroid stimulating hormone, free T3 and free T4 levels were studied. Liver ultrasound was applied to all cases. Results: Totally 1282 cases, 620 with NAFLD and 662 controls were included in the study. The prevalence of subclinical hypothyroidism among cases with grade 1, grade 2 and grade 3 NAFLD were as follows; 4,0%, 5,7%, and 10,8% respectively, while this ratio was 2,8% in control group. In statistical evaluation, the prevalence of subclinical hypothyroidism was statistically and significantly higher in grade 3 NAFLD group than all other groups (p:0.001) Conclusions: The association of subclinic hypothyroidism with grade 3 NAFLD is important in clinical practice since both conditions are very common. Moreover, molecular studies to determine the association of hypothyroidism with fatty liver disease may elucidate new treatment modalities.

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Yeni Tıp Dergisi-Cover
  • ISSN: 1300-2317
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2018
  • Yayıncı: -
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