Ahmet Toygar KALKAN, Bilge BAŞDOĞAN, Özge ÖZER, Fatma Belgin EFE, Nur KEBAPÇI, Aysen AKALIN, Göknur YORULMAZ

Glargine u300'ün Düşük Yoğunluklu Lipoprotein (LDL), Trigliserid (TG) ve Kan Şekeri Düzeyleri Üzerindeki Etkileri: Gerçek Yaşam Sonuçları

Amaç: Gerçek hayatta yeni nesil insülin glarjin u-300'ün açlık kan şekeri, HbA1c, LDL ve trigliserit düzeylerine etkisini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Eskişehir Osmangazi Üniversitesi Endokrinoloji ve Metabolizma polikliniğine 2019 yılında başvuran, eski nesil bazal insülin yerine glargine u-300 kullanılan ve antilipidemik tedavisi değişmeyen hastaları geriye dönük olarak inceledik. Başlangıçta ve 3 ay sonra açlık kan şekeri(mg/dl), HbA1c(%), LDL(mg/dl) ve trigliserit(mg/dl) değerlerini karşılaştırdık. Biz de bu verileri cinsiyetlere continayırarak değerlendirdik. Sürekli değişkenler için Shapiro-Wilk normallik testi yapıldı. Normal dağılım gösteren değişkenler için paired sample t testi, normal dağılım göstermeyen değişkenler için Wilcoxon Signed Ranks testi uygulandı. Bulgular: 109 hasta ile ilgili veriler analiz edildi. Açlık kan şekeri ortalaması ve medyan değeri kontrolde glarjin u-300'e başladıktan sonra azaldı. Ancak istatistiksel olarak farklı değildi(p=0,06). HbA1c kontrol değeri (%8,8) başlangıç değerine (%9,61) göre istatistiksel olarak anlamlı derecede azaldı (p

Anahtar Kelimeler:

Glargine u-300, LDL, HbA1c, triglyceride

Effects of Glargine u300 on Low-Density Lipoprotein (LDL), Triglyceride(TG) and Blood Glucose Levels: Real-Life Outcomes

Aim: In real life, we aimed to evaluate the effect of new generation insulin glargine u-300 on fasting blood glucose, HbA1c, LDL and triglyceride levels. Material and Methods: This is a retrocspective cohort study. We retrospectively reviewed patients who applied to the Endocrinology and metabolism outpatient clinic of Eskişehir Osmangazi University in 2019, whose old generation basal insulin was replaced with glargine u-300 and whose antilipidemic treatment was not changed. We compared fasting blood glucose(mg/dl), HbA1c(%), LDL(mg/ dl) and triglyceride(mg/dl) values at baseline and after 3 months. We also evaluated these data by separating them into genders. Shapiro– Wilk normality test was performed for continuous variables. Wilcoxon Signed Ranks test was performed for non-normally distributed variables. Results: Data concerning 109 patients were analysed. The fasting blood glucose average and median value decreased in control after starting glarjin u-300. However, it was not statistically different (p=0.06). The HbA1c control value (8.8%) decreased statistically significantly compared to the baseline value (9.61%) (p

Keywords:

Glargine u-300, LDL, HbA1c, triglyceride,

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