Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology?

Amaç Biyokimyasal belirteçler karın ağrısının sebebinin erken tanısında oldukça önemlidir. Bu çalışmada FABP'nin intestinal tipinin (I-FABP) abdominal patolojisi olan hastaların ayırıcı tanısındaki değeri araştırıldı.Gereç ve YöntemMevcut çalışma üniversite hastanesi acil servisinde ileriye yönelik tanımlayıcı olarak çalışma gerçekleştirildi. Karın ağrısı şikayeti ile acil servise başvuran hastalarda başvuru anında alınan serum örneklerinden I-FABP değerlerine bakıldı. Bulgular sağlıklı gönüllülerdeki düzeyler ile karşılaştırıldı.BulgularKayıtlı 171 hastada ölçülen ortalama I-FABP seviyesi 170.1±543.4 pg/ml olarak belirlendi. Sağlıklı gönüllülerde I-FABP seviyesi 61.4±47.4 pg/ml olarak bulundu. Hasta grubunun I-FABP seviyeleri sağlıklı gönüllülere göre yüksek olarak bulunmuşsa da, aradaki fark istatistiksel olarak anlamlı değildi (p>0.05). Başvuru anında ölçülen I-FABP seviyeleri sağlıklı gönüllülerle kıyaslandığında akut mezenter iskemide (AMI) ve karıniçi kitle tespit edilen hastalarda istatistiksel olarak anlamlı yüksekti (p

FABP'nin İntestinal Tipi (I-FABP) Abdominal Patolojilerin Tanısında Belirteç Olabilir mi?

ObjectivesBiochemical markers play an important role in the early diagnosis of abdominal pain. This study aimed to investigate the diagnostic value of intestinal type fatty acid binding protein (I-FABP) in patients with abdominal pathology.MethodsThis prospective and descriptive study was performed at the University Hospital Emergency Department. Serum I-FABP levels of patients presenting with acute abdominal pain were measured at time of admission and were compared with those of healthy individuals.ResultsThe mean I-FABP level of the 171 patients enrolled in this study was 170.1±543.4 pg/ml, while that of a healthy control group was 61.4±47.4 pg/ml. Although I-FABP levels were higher in the patient group, this difference was not statistically significant (p>0.05). However, I-FABP levels of patients with mesenteric ischemia and intra-abdominal mass were significantly higher than those of healthy individuals (p<0.05).ConclusionsI-FABP levels that are evaluated at time of admission in patients presenting with abdominal pain to the emergency department are significantly higher in patients with mesenteric ischemia and intraabdominal mass than are those of healthy individuals.

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Türkiye Acil Tıp Dergisi
  • ISSN: 1304-7361
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2000

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