Effects of Cadmium Compounds (Cadmium Para Hydroxybenzoate and Cadmium Chloride) on the Liver of Mature Mice

In this study, 4 experimental groups and 1 control group containing adult mice (Mus musculus var. albinos) were used to examine the effects of 2 different cadmium compounds, namely cadmium para hydroxybenzoate, which was newly synthesized, and cadmium chloride on the liver of mice. In various test concentrations, both cadmium compounds were intraperitoneally injected into adult mice every day for 15 days. With standard histological techniques samples were obtained from the livers of the mice. Slides were prepared and examined with light microscopy (Nikon Eclipse E600) and histopathological structures were observed.

Effects of Cadmium Compounds (Cadmium Para Hydroxybenzoate and Cadmium Chloride) on the Liver of Mature Mice

In this study, 4 experimental groups and 1 control group containing adult mice (Mus musculus var. albinos) were used to examine the effects of 2 different cadmium compounds, namely cadmium para hydroxybenzoate, which was newly synthesized, and cadmium chloride on the liver of mice. In various test concentrations, both cadmium compounds were intraperitoneally injected into adult mice every day for 15 days. With standard histological techniques samples were obtained from the livers of the mice. Slides were prepared and examined with light microscopy (Nikon Eclipse E600) and histopathological structures were observed.

___

  • Cherian, M. G. and Goyer, R. A. 1989. Cadmium toxicity. Comm. Toxicol. 3: 191- 206
  • Chin, T. A. and Templenton, D.M. 1993. Protective elevations of glutathione and metallothionein in cadmium-exposed mesangial cells. Toxicology. 77: 145-156.
  • Copius Peereboom-Stegeman, J.H.J. 1989. Cadmium effects on the female reproductive tract. Toxicol. Environ. Chem. 23: 9-91.
  • Datta, S.S., Mallick, P.P. and Khuda-Bukhsh, A.R. 2001. Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study.BMC Complement Altern. Med. 1: 9.
  • DelRaso, N.J., Foy, B.D., Gearhart, J.M. and Frazier, J.M. 2003. Cadmium uptake kinetics in rat hepatocytes correction for albumin binding. Toxicol. Sci. 72:19-30.
  • Dudley, R.E., Svoboda, D.J. and Klaassen, C.D. 1982. Acute exposure to cadmium causes liver severe injury in rats. Toxicol. Appl. Pharmacol. 65: 302-313.
  • Dudley, R.E., Svoboda, D.J. and Klaassen, C.D. 1984. Time course of cadmium induced ultrastructural changes in rat liver. Toxicol. Appl. Pharmacol. 76: 150-160.
  • Goerging, P.L. and Klaassen, C.D. 1983. Altered subcellular distribution of cadmium following cadmium pretreatment: possible mechanism of tolerance to cadmium-induced lethality. Toxicol. Appl. Pharmacol. 70: 195-203..
  • Goyer, R.A. and Cherian, M.G. 1995. Renal effects of metals. In metal toxicology, academic press San Diego, CA., pp. 389-412.
  • Goyer, R.A. 1997. Toxic and essential metal interactions. Annu. Rev. Nutr. 17: 37-50.
  • Habeebu, S.S.M., Liu, J. and Klaassen, C.D. 1998. Cadmium-induced apoptosis in mouse liver. Toxicol. Appl. Pharmacol. 149: 203- 209.
  • Habeebu, S.S.M., Liu, J., Liu, Y. and Klaassen, C.D. 2000. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to Cadmium. Toxicol. Sci. 55: 223-232.
  • Harstad, E.B. and Klaassen, C.D. 2002. Analysis Strain Difference in Sensitivity to Cadmium-Induced Hepatotoxicity in Fischer 344 and Sprague-Dawley rats. Toxicol. Sci. 67:327-340.
  • Jeong, S.H., Habeebu, S.S.M. and Klaassen, C.D. 2000. Cadmium decreases gap juctional intercellular communication in mouse liver. Toxicol. Sci. 57: 156-166.
  • Kuester, R.K., Waalkes, M.P., Goering, P.L., Fisher, B.L., McCuskey, R.S. and Sipes, I.G. 2002. Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats. Toxicol. Sci. 65: 151 – 159.
  • Piasek, M. and Kostial, K. 1996. Experimental studies on reproductive and perinatal effect of lead and cadmium.. Environmental Management and Health. 7: 29-34.
  • Solaiman, D., Jonah, M.M., Miyazaki, W.Ho.G. and Bhattacharyya, M.H. 2001. Increased metallothionein in mouse liver, kidneys and duodenum during lactation. Toxicol. Sci. 60: 184-192.
  • Sorahan, T. and Lancashire, R.J. 1997. Lung cancer mortality in a cohort of workers employed at a cadmium recovery plant in the United States: And analysis with detailed job histories. Occup. Environ. Med. 54: 194-201.
  • Soto, A. Foy, B.D. and Frazier, J.M. 2002. Effect of cadmium on bromosulfophthalein kinetics in the isolated perfused rat liver system. Toxicol. Sci. 69: 460-469.
  • Sugawara, N., Lai, Y.R., Arizono, K., Kitajima, T. and Inoue, H. 1997. Lack of biliary excretion of cadmium linked to an inherent defect of the canalicular isoform of multidrug resistance protein (cMrp) does not abnormally stimulate accumulation of Cd in the Eisai hyperbilirubinemic (EHB) rat liver. Arch. Toxicol. 71: 336-339.
  • Tzirogiannis, K.N., Panoutsopoulos, G.I., Demonakou, M.D., Hereti, R.I., Alexandropoulou, K.N., Basayannis, A.C. and Mykoniatis, M.G. 2003. Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis. Arch. Toxicol. 77: 694-701.
Turkish Journal of Zoology-Cover
  • ISSN: 1300-0179
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK