The FecB (Booroola) gene and implications for the Turkish sheep industry
Most traits of economic importance in livestock are quantitative traits. This means that they are influenced by a large number of genes, each contributing a small effect, scattered across the genome. Selection for these genes requires specialized methods such as progeny testing or genomic selection. The FecB or Booroola gene is an exception. Presence of this single gene increases ovulation and lambing rates dramatically with ewes producing 2, 3, or even more lambs per parturition. The FecB gene was first observed indirectly in Australian Merino sheep by Dr Helen Newton Turner. It was later determined that this allele was a single amino acid mutation in the bone morphogenetic protein receptor type 1B (BMPR1B) gene on chromosome 6 and it was designated FecB, where Fec stands for the fecundity locus and B for the Booroola gene. FecB probably originated in India and has now spread to 48 breeds and composites in 19 countries. Sheep production in Turkey has been declining over the past 20 years for many reasons, but the demand for sheep products remains high. Increased lambing rates could increase sheep production in Turkey, but changes in traditional practices of extensive, low input, and low output sheep production would probably be required.
The FecB (Booroola) gene and implications for the Turkish sheep industry
Most traits of economic importance in livestock are quantitative traits. This means that they are influenced by a large number of genes, each contributing a small effect, scattered across the genome. Selection for these genes requires specialized methods such as progeny testing or genomic selection. The FecB or Booroola gene is an exception. Presence of this single gene increases ovulation and lambing rates dramatically with ewes producing 2, 3, or even more lambs per parturition. The FecB gene was first observed indirectly in Australian Merino sheep by Dr Helen Newton Turner. It was later determined that this allele was a single amino acid mutation in the bone morphogenetic protein receptor type 1B (BMPR1B) gene on chromosome 6 and it was designated FecB, where Fec stands for the fecundity locus and B for the Booroola gene. FecB probably originated in India and has now spread to 48 breeds and composites in 19 countries. Sheep production in Turkey has been declining over the past 20 years for many reasons, but the demand for sheep products remains high. Increased lambing rates could increase sheep production in Turkey, but changes in traditional practices of extensive, low input, and low output sheep production would probably be required.
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- Davis GH. The Booroola gene: origin, distribution, use and management of the FecB mutation. In: Proceedings of the Helen Newton Turner Memorial International Workshop, Pune, Maharashtra, India. Canberra, Australia: Australian Centre for International Agricultural Research: Canberra, Australia; 200 pp. 22–31. Turner HN. Selection for reproduction rate in Australian Merino sheep: direct responses. Aust J Agr Res 1978; 29: 327– 3
- Piper LR, Bindon BM. The Booroola Merino and the performance of medium non-peppin crosses at Armidale. In: The Booroola Merino, Proceedings of a Workshop. Armidale, New South Wales, Australia: CSIRO; 1982. pp. 9–19.
- Turner HN. Origins of the CSIRO Booroola. In: The Booroola Merino: Proceedings of a Workshop. Armidale, New South Wales, Australia: CSIRO; 1982. pp. 1–7.
- Lauvergne JJ, Dollings CHS, Renieri C. Mendelian inheritance in sheep. Camerino, Italy: University of Camerino Press; 19 Mulsant P, Lecerf F, Fabre S, Schibler L, Monget P, Lanneluc I, Pisselet C, Riquet J, Monniaux D, Callebaut I et al. Mutation in bone morphogenetic protein receptor-1B is associated with increased ovulation rate in Booroola Merino ewes. Proc Natl Acad Sci USA 2001; 98: 5104–5109.
- Wilson T, Wu XY, Juengel JL, Ross IK, Lumsden JM, Lord EA, Dodds KG, Walling GA, McEwan JC, O’Connell AR et al. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulose cells. Biol Reprod 2001; 64: 1225–1235.
- Souza CJ, MacDougall C, Campbell BK, McNeilly AS, Baird DT. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1B (BMPR1B) gene. J Endocrinol 2001; 169: R1–6.
- Notter DR, Thomas DL, Waldron DF. Biological and economic consequences of the FecB mutation in the USA. In: Proceedings of the Helen Newton Turner Memorial International Workshop, Pune, Maharashtra, India. Canberra, Australia: Australian Centre for International Agricultural Research; 200 pp. 152–157. Walkden-Brown SW, Wolfenden DH, Piper LR. Biological and economic consequences of introgression of the FecB mutation into Merino sheep in Australia. In: Proceedings of the Helen Newton Turner Memorial International Workshop, Pune, Maharashtra, India. Canberra, Australia: Australian Centre for International Agricultural Research; 200 pp. 100–110 Arora AL, Mishra AK, Prince LLL. Consequences of introgression of the FecB gene into Malpura sheep in Rajasthan. In: Proceedings of the Helen Newton Turner Memorial International Workshop, Pune, Maharashtra, India. Canberra, Australia: Australian Centre for International Agricultural Research; 200 pp. 111–118 Gootwine E. Biological and economic consequences of introgressing the B allele of the FecB (Booroola) gene into Awassi and Assaf sheep. In: Proceedings of the Helen Newton Turner Memorial International Workshop, Pune, Maharashtra, India. Canberra, Australia: Australian Centre for International Agricultural Research; 200 pp. 119–127