Risk factors of clinical and subclinical endometritis in cattle: a review
The postpartum period is a critical period in the life of dairy cattle and management of the most important problems and diseases at an early stage represents the key to successful dairy herd management. Endometritis is one of the most important and dramatic diseases that disrupt the reproductive performance of cows and reduce the livestock profitability. Because endometritis is a multifactorial disease and is caused by nonspecific bacteria, determining all the factors that enhance its risk of occurrence is more important than treating the disease. This review considers the evidence regarding the risk factors for postpartum endometritis in dairy cattle in an attempt to explain the causality between each risk factor and both clinical and subclinical endometritis. The present article will discuss the importance of determining the risk factors of endometritis that must be considered for the treatment of cows. For example, antibiotics must be associated with improvement of the rations in the case of nutritional deficit and metabolic problems. Furthermore, these risk factors represent an alternative to treatment by including them in an adequate preventive strategy to master at least the most important risk factor to limit the prevalence and severity of endometritis. We conclude that some factors are specific for one form of endometritis and some others are common between clinical and subclinical endometritis, but all of them make the disease more severe and frequent.
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- Vergara CF, Dopfer D, Cook NB, Nordlund KV, McArt JA,
Nydam DV, Oetzel GR. Risk factors for postpartum problems
in dairy cows: explanatory and predictive modeling. J Dairy Sci
2014; 97: 4127-4140.
- Sheldon IM, Cronin J, Goetze L, Donofrio G, Schuberth HJ.
Defining postpartum uterine disease and the mechanisms of
infection and immunity in the female reproductive tract in
cattle. Biol Reprod 2009; 8: 1025-1032.
- Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO. Defining
postpartum uterine disease in cattle. Theriogenology 2006; 65:
1516-1530.
- Madoz LV, Giuliodori MJ, Migliorisi AL, Jaureguiberry M, de
la Sota RL. Endometrial cytology, biopsy, and bacteriology for
the diagnosis of subclinical endometritis in grazing dairy cows.
J Dairy Sci 2014; 97: 195-201.
- Gilbert RO, Shin ST, Guard CL, Erb HN, Frajblat M. Prevalence
of endometritis and its effects on reproductive performance of
dairy cows. Theriogenology 2005; 64: 1879-1888.
- LeBlanc SJ. Postpartum uterine disease and dairy herd
reproductive performance: a review. Vet J 2008; 176: 102-114.
- Cheong SH, Nydam DV, Galvao KN, Crosier BM, Gilbert
RO. Cow-level and herd-level risk factors for subclinical
endometritis in lactating Holstein cows. J Dairy Sci 2011; 94:
762-770.
- Williams EJ, Fischer DP, Pfeiffer DU, England GC, Noakes DE,
Dobson H, Sheldon IM. Clinical evaluation of postpartum
vaginal mucus reflects uterine bacterial infection and the
immune response in cattle. Theriogenology 2005; 63: 102-117.
- Prunner I, Pothmann H, Wagener K, Giuliodori M, Huber J,
Ehling-Schulz M, Drillich M. Dynamics of bacteriologic and
cytologic changes in the uterus of postpartum dairy cows.
Theriogenology 2014; 82: 1316-1322.
- Prunner I, Wagener K, Pothmann H, Ehling-Schulz M, Drillich
M. Risk factors for uterine diseases on small- and medium-
sized dairy farms determined by clinical, bacteriological, and
cytological examinations. Theriogenology 2014; 82: 857-865.
- Kim IH, Kang HG. Risk factors for postpartum endometritis
and the effect of endometritis on reproductive performance in
dairy cows in Korea. J Reprod Develop 2003; 49: 485-491.
- Potter TJ, Guitian J, Fishwick J, Gordon PJ, Sheldon IM. Risk
factors for clinical endometritis in postpartum dairy cattle.
Theriogenology 2010; 74: 127-134.
- Ghavi Hossein-Zadeh N, Ardalan M. Cow-specific risk factors
for retained placenta, metritis and clinical mastitis in Holstein
cows. Vet Res Commun 2011; 35: 345-354.
- Salasel B, Mokhtari A, Taktaz T. Prevalence, risk factors for
and impact of subclinical endometritis in repeat breeder dairy
cows. Theriogenology 2010; 74: 1271-1278.
- Bacha B, Regassa FG. Subclinical endometritis in Zebu x
Friesian crossbred dairy cows: its risk factors, association with
subclinical mastitis and effect on reproductive performance.
Trop Anim Health Prod 2010; 42: 397-403.
- Carneiro LC, Ferreira AF, Padua M, Saut JP, Ferraudo AS, Dos
Santos RM. Incidence of subclinical endometritis and its effects
on reproductive performance of crossbred dairy cows. Trop
Anim Health Prod 2014; 46: 1435-1439.
- Bruun J, Ersboll AK, Alban L. Risk factors for metritis in
Danish dairy cows. Prev Vet Med 2002; 54: 179-190.
- Parkinson T. Infertility and subfertility in the cow: structural
and functional abnormalities, management deficiencies and
non-specific infections. In: Noakes DE, Parkinson T, England
GCW, editors. Veterinary Reproduction and Obstetrics.
Amsterdam, the Netherlands: Elsevier; 2009. p. 393-475.
- Markusfeld O. Factors responsible for post parturient metritis
in dairy cattle. Vet Rec 1984; 114: 539-542.
- Dubuc J, Duffield TF, Leslie KE, Walton JS, LeBlanc SJ. Risk
factors for postpartum uterine diseases in dairy cows. J Dairy
Sci 2010; 93: 5764-5771.
- Badinand F. Les métrites chez la vache : influence des facteurs
hormonaux et nutritionnels. Cah Méd Vet 1975; 44: 205-221
(in French).
- Bencharif D, Tainturier D. Les métrites chroniques chez les
bovins. Point Vét 2005; 36: 72-77 (in French).
- Sato S, Suzuki T, Okada K. Suppression of lymphocyte
blastogenesis in cows with puerperal metritis and mastitis. J
Vet Med Sci 1995; 57: 373-375.
- Ducreux P. Le sélénium chez les bovins : rôles biologiques et
manifestations de carences. DVM, Ecole vétérinaire de Lyon,
Lyon, France, 2003 (in French).
- LeBlanc SJ. Reproductive tract inflammatory disease in
postpartum dairy cows. Animal 2014; 8: 54-63.
- MacKay D, Miller AL. Nutritional support for wound healing.
Altern Med Rev 2003; 8: 359-377.
- Mayer E. Relations entre alimentation et infécondité. Bull GTV
1978; 78: 132 (in French).
- Rutigliano HM, Lima FS, Cerri RLA, Greco LF, Vilela JM,
Magalhães V, Silvestre FT, Thatcher WW, Santos JEP. Effects
of method of presynchronization and source of selenium on
uterine health and reproduction in dairy cows. J Dairy Sci
2008; 91: 3323-3336.
- Chaffaux S, Lakdissi H, Thibier M. Etude épidémiologique et
clinique des endométrites post-puerpérales chez les vaches
laitières. Rec Méd Vét 1991; 167: 349-358 (in French).
- Giuliodori MJ, Magnasco RP, Becu-Villalobos D, Lacau-
Mengido IM, Risco CA, de la Sota RL. Clinical endometritis
in an Argentinean herd of dairy cows: risk factors and
reproductive efficiency. J Dairy Sci 2013; 96: 210-218.
- Thibier M, Steffan J. Les métrites dans la pathologie du post-
partum chez la vache laitière. Epidémiologie et cyclicité in
Mieux connaître, comprendre et maîtriser la fécondité bovine.
Journée de la société française de buiatrie 1985: 157-183 (in
French).
- Correa MT, Erb H, Scarlett J. Path analysis for seven postpartum
disorders of Holstein cows. J Dairy Sci 1993; 76: 1305-1312.
- Dohmen MJ, Joop K, Sturk A, Bols PE, Lohuis JA. Relationship
between intra-uterine bacterial contamination, endotoxin
levels and the development of endometritis in postpartum
cows with dystocia or retained placenta. Theriogenology 2000;
54: 1019-1032.
- Morton JM, Butler KL. The effects of induced parturition on
the incidence of clinical disease and mortality in dairy cows
from commercial herds in south-western Victoria. Aust Vet J
1995; 72: 1-4.
- Benedictus L, Jorritsma R, Knijn HM, Vos PL, Koets AP.
Chemotactic activity of cotyledons for mononuclear leukocytes
related to occurrence of retained placenta in dexamethasone
induced parturition in cattle. Theriogenology 2011; 76: 802-
809.
- Muller LD, Owens MJ. Factors associated with the incidence of
retained placentas. J Dairy Sci 1974; 57: 725-728.
- Sheldon IM, Dobson H. Postpartum uterine health in cattle.
Anim Reprod Sci 2004; 82-83: 295-306.
- Laven RA, Peters AR. Bovine retained placenta: aetiology,
pathogenesis and economic loss. Vet Rec 1996; 139: 465-471.
- Whiteford LC, Sheldon IM. Association between clinical
hypocalcaemia and postpartum endometritis. Vet Rec 2005;
157: 202-203.
- Roche JF. The effect of nutritional management of the dairy
cow on reproductive efficiency. Anim Reprod Sci 2006; 96:
282-296.
- Guterbock WM. Diagnosis and treatment programs for fresh
cows. Vet Clin North Am Food Anim Pract 2004; 20: 605-626.
- Curtis CR, Erb HN, Sniffen CJ, Smith RD, Kronfeld DS. Path
analysis of dry period nutrition, postpartum metabolic and
reproductive disorders, and mastitis in Holstein cows. J Dairy
Sci 1985; 68: 2347-2360.
- Markusfeld O. Periparturient traits in seven high dairy herds.
Incidence rates, association with parity, and interrelationships
among traits. J Dairy Sci 1987; 70: 158-166.
- LeBlanc SJ, Osawa T, Dubuc J. Reproductive tract defense and
disease in postpartum dairy cows. Theriogenology 2011; 76:
1610-1618.
- Hammon DS, Evjen IM, Dhiman TR, Goff JP, Walters JL.
Neutrophil function and energy status in Holstein cows with
uterine health disorders. Vet Immunol Immunopathol 2006;
113: 21-29.
- Ingvartsen KL, Moyes K. Nutrition, immune function and
health of dairy cattle. Animal 2013; 7: 112-122.
- Suthar VS, Canelas-Raposo J, Deniz A, Heuwieser W.
Prevalence of subclinical ketosis and relationships with
postpartum diseases in European dairy cows. J Dairy Sci 2013;
96: 2925-2938.
- Goff JP, Horst RL. Physiological changes at parturition and
their relationship to metabolic disorders. J Dairy Sci 1997; 80:
1260-1268.
- Sartorelli P, Paltrinieri S, Agnes F. Non-specific immunity
and ketone bodies. I: In vitro studies on chemotaxis and
phagocytosis in ovine neutrophils. Zentralbl Veterinarmed A
1999; 46: 613-619.
- Frazer GS. A rational basis for therapy in the sick postpartum
cow. Vet Clin North Am Food Anim Pract 2005; 21: 523-568.
- Steffan J. Métrites en élevage bovin laitier. Quelques facteurs
influencant leur fréquence et leurs conséquences sur la fertilité.
Rec Méd Vét 1987; 166: 183-188 (in French).
- Kadivar A, Ahmadi MR, Vatankhah M. Associations of
prepartum body condition score with occurrence of clinical
endometritis and resumption of postpartum ovarian activity in
dairy cattle. Trop Anim Health Prod 2014; 46: 121-126.
- Mani V, Weber TE, Baumgard LH, Gabler NK. Growth and
Development Symposium: Endotoxin, inflammation, and
intestinal function in livestock. J Anim Sci 2012; 90: 1452-
1465.
- Sérieys. Le tarissement de la vache laitière. Paris, France:
France agricole; 1997 (in French).
- Sheldon IM, Price SB, Cronin J, Gilbert RO, Gadsby JE.
Mechanisms of infertility associated with clinical and
subclinical endometritis in high producing dairy cattle. Reprod
Domest Anim 2009; 44: 1-9.
- Olson JD, Ball L, Mortimer RG, Farin PW, Adney WS, Huffman
EM. Aspects of bacteriology and endocrinology of cows with
pyometra and retained fetal membranes. Am J Vet Res 1984;
45: 2251-2255.
- Galvao KN, Flaminio MJ, Brittin SB, Sper R, Fraga M, Caixeta
L, Ricci A, Guard CL, Butler WR, Gilbert RO. Association
between uterine disease and indicators of neutrophil and
systemic energy status in lactating Holstein cows. J Dairy Sci
2010; 93: 2926-2937.
- Kaneene JB, Miller R. Risk factors for metritis in Michigan
dairy cattle using herd- and cow-based modelling approaches.
Prev Vet Med 1995; 23: 183-200.
- Gautam G, Nakao T, Koike K, Long ST, Yusuf M, Ranasinghe
RM, Hayashi A. Spontaneous recovery or persistence of
postpartum endometritis and risk factors for its persistence in
Holstein cows. Theriogenology 2010; 73: 168-179.
- Gautam G, Nakao T, Yusuf M, Koike K. Prevalence of
endometritis during the postpartum period and its impact on
subsequent reproductive performance in two Japanese dairy
herds. Anim Reprod Sci 2009; 116: 175-187.