Malignant giant-cell tumor of bone with lymph node involvement in a cat
The present study describes giant-cell tumor of bone (GCToB) with lymph node involvement in a 5-year-old crossbred cat. The animal was referred to the surgery clinic with progressive subcutaneous swelling in the left proximal femoral region, severe lameness, constipation, and dysuria. A moderately firm, subcutaneous, palpable mass, 9 cm in diameter, was observed, and biopsy samples were taken. Histopathologically, the mass was constituted by ovoid-shaped mononuclear cells intermixed with many multinucleated giant cells (MGC). Immunohistochemically, the giant cells were positively stained with antivimentin, and the same cells were negative for antidesmin and anti-S100 staining. Tartrate-resistant acid phosphatase (TRAP) activity in tumor cells was evaluated and the tumor was diagnosed as malignant GCToB; the cat was euthanized. Macroscopically, while the regional lymph nodes were intact, giant cells were found in the left popliteal lymph node during microscopy. Although a few cases of GCToB have been reported in cats, the case herein displays, for the first time, evidence of lymph node involvement during the process of metastasis.
Malignant giant-cell tumor of bone with lymph node involvement in a cat
The present study describes giant-cell tumor of bone (GCToB) with lymph node involvement in a 5-year-old crossbred cat. The animal was referred to the surgery clinic with progressive subcutaneous swelling in the left proximal femoral region, severe lameness, constipation, and dysuria. A moderately firm, subcutaneous, palpable mass, 9 cm in diameter, was observed, and biopsy samples were taken. Histopathologically, the mass was constituted by ovoid-shaped mononuclear cells intermixed with many multinucleated giant cells (MGC). Immunohistochemically, the giant cells were positively stained with antivimentin, and the same cells were negative for antidesmin and anti-S100 staining. Tartrate-resistant acid phosphatase (TRAP) activity in tumor cells was evaluated and the tumor was diagnosed as malignant GCToB; the cat was euthanized. Macroscopically, while the regional lymph nodes were intact, giant cells were found in the left popliteal lymph node during microscopy. Although a few cases of GCToB have been reported in cats, the case herein displays, for the first time, evidence of lymph node involvement during the process of metastasis.
___
- Walsh, B.A., Rhodes, W.H.: Giant cell tumour of bone in a cat.
- J. Small Anim. Pract., 1995; 36: 325-329.
- Th ornburg, P.: Giant cell tumour of bone in a cat. Vet. Pathol., 1979; 16: 255-257.
- Jösten, M., Rudolph, A.: Methods for the diff erentiation of giant cells in canine and feline neoplasias in paraffi n sections. Zentralbl. Veterinarmed. A., 1997; 44: 159-166.
- Zheng, M.H., Robbins, P., Xu, J., Huang, L., Wood, D.J., Papadimitriou, J.M.: Th e histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts. Histol Histopathol., 2001; 16: 297-307.
- Akkoc, A., Ozyigit, M.O., Cangul, I.T.: Valvular cardiac myxoma in a dog. J. Vet. Med. A., 2005; 54: 356-358.
- Toyosawa, S., Ogawa, Y., Chang, C.K., Hong, S.S., Yagi, T., Kuwahara, H., Wakasa, K., Sakurai, M.: Histochemistry of tartrate-resistant acid phosphatise and carbonic anhydrase isoenzyme II on osteoclast-like giant cells bone tumours. Virchows Arch. Pathol. Anat. Histopathol., 1991; 418: 255-261.
- Garma-Avina, A.: Malignant fi brous histiocytoma of the giant cell type in a cat. J. Comp. Pathol., 1987; 97: 551-557.