Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin

Öz In this study, combination antimicrobial therapy, due to its higher potential against resistant bacteria, was evaluated for the inhibition of multidrug-resistant E. coli strains. The influence of pH as an environmental variable on the activity of antimicrobial combinations was evaluated by calculating the factional concentration indexes at pH values 5.0, 6.0, 7.3, and 8.0. The highest synergistic activity rates of ceftriaxone + colistin, danofloxacin + colistin, danofloxacin + ceftiofur, and ceftiofur + gentamicin combinations were 50%, 33%, 100%, and 50%, respectively measured at ≥7.3 pH. The lowest synergistic activity rates for all combinations were observed at the acidic pH values of 5.0 and 6.0. The results of this study clearly demonstrated that acidic pH of the medium impaired the activity of the antimicrobial combinations. Although ceftriaxone and ceftiofur exert optimal activity at acidic pH values, the synergistic activity of the co-used drugs reached its highest level at pH ≥7.3.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkveterinary783787, journal = {Turkish Journal of Veterinary and Animal Sciences}, issn = {1300-0128}, eissn = {1303-6181}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {747 - 751}, doi = {10.3906/vet-1912-67}, title = {Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin}, key = {cite}, author = {Cengiz, Murat and Hepbostancı, Gülçe} }
APA Cengiz, M , Hepbostancı, G . (2020). Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin . Turkish Journal of Veterinary and Animal Sciences , 44 (3) , 747-751 . DOI: 10.3906/vet-1912-67
MLA Cengiz, M , Hepbostancı, G . "Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin" . Turkish Journal of Veterinary and Animal Sciences 44 (2020 ): 747-751 <https://dergipark.org.tr/tr/pub/tbtkveterinary/issue/56433/783787>
Chicago Cengiz, M , Hepbostancı, G . "Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin". Turkish Journal of Veterinary and Animal Sciences 44 (2020 ): 747-751
RIS TY - JOUR T1 - Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin AU - Murat Cengiz , Gülçe Hepbostancı Y1 - 2020 PY - 2020 N1 - doi: 10.3906/vet-1912-67 DO - 10.3906/vet-1912-67 T2 - Turkish Journal of Veterinary and Animal Sciences JF - Journal JO - JOR SP - 747 EP - 751 VL - 44 IS - 3 SN - 1300-0128-1303-6181 M3 - doi: 10.3906/vet-1912-67 UR - https://doi.org/10.3906/vet-1912-67 Y2 - 2021 ER -
EndNote %0 Turkish Journal of Veterinary and Animal Sciences Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin %A Murat Cengiz , Gülçe Hepbostancı %T Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin %D 2020 %J Turkish Journal of Veterinary and Animal Sciences %P 1300-0128-1303-6181 %V 44 %N 3 %R doi: 10.3906/vet-1912-67 %U 10.3906/vet-1912-67
ISNAD Cengiz, Murat , Hepbostancı, Gülçe . "Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin". Turkish Journal of Veterinary and Animal Sciences 44 / 3 (Haziran 2020): 747-751 . https://doi.org/10.3906/vet-1912-67
AMA Cengiz M , Hepbostancı G . Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(3): 747-751.
Vancouver Cengiz M , Hepbostancı G . Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(3): 747-751.
IEEE M. Cengiz ve G. Hepbostancı , "Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin", Turkish Journal of Veterinary and Animal Sciences, c. 44, sayı. 3, ss. 747-751, Haz. 2020, doi:10.3906/vet-1912-67

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