Flor Zehirlenmesi Oluşturulmuş Tavşanlarda Toplam Testosteron, Kortizol, Büyüme Hormonu ve Flor Düzeyleri
Bu çal›flmada, subkronik olarak (70 gün) içme suyu ile verilen florun (1, 10 ve 40 mg/L) Yeni Zelanda ›rk› erkek tavflanlarda toplam testosteron, kortizol ve büyüme hormonu (BH) seviyelerine etkisi incelenmifltir. Kontrol ve deney gruplar›ndan 0., 21. ve 70. günlerde kan al›narak toplam testosteron, kortizol, BH ve flor düzeyi ölçülmüfltür. Denemeler sonucunda, 10 mg/L miktarda flor içeren su verilen hayvanlarda 21. günde kortizol düzeyinin önemli flekilde (p<0,01) düfltü¤ü, testosteron seviyesindeki düflüflün ve büyüme hormonu seviyesindeki art›fl›n önemli olmad›¤›; 10 mg/L flor içeren su verilen hayvanlarda 70. günde kortizol ve BH seviyesindeki düflmenin önemli (p<0,01) oldu¤u; 40 mg/L flor içeren su verilen hayvanlarda 21. günde kortizol ve BH miktarlar›ndaki azalman›n önemli (p<0,01) oldu¤u; 40 mg/L flor içeren su verilen hayvanlarda 70. günde testosteron seviyesindeki düflmenin önemli (p<0,05), kortizol ve BH düzeyindeki düflmenin çok önemli (p<0,001) oldu¤u; tür doz ve uygulama sürelerinde vücuttaki flor seviyesinin önemli ölçüde art›¤› (p<0,001) ortaya konulmufltur.
Total Testosterone, Cortizol, Growth hormone and Fluorine Levels in Fluorine Intoxicated Rabbits
In this study, the effects of fluorine given subchronically (70 days) in drinking water (1, 10, 40 mg/L) were assessed in New Zealand male rabbits and their effects on total testosterone, cortisol and growth hormone (GH) levels were determined. Blood samples were taken from control and experimental groups after 0, 21 and 70 days and total testosterone, cortisol, GH and fluorine levels were measured. As a result, in animals given 10 mg/L fluorinated water, on the 21st day there was a statistically significant (p<0.01) drop in the cortisol levels and it was found that the drop in the testosterone levels and the rise in the GH levels were statistically insignificant. In animals given 10 mg/L fluorinated water, the drops in the cortisol and GH levels on the 70th day were statistically significant (p<0.01). In animals given 40 mg/L fluorinated water, the drops in the cortisol and GH levels on the 21st day were statistically significant (p<0.01). Also, on the 70th day the drop in the testosterone levels was statistically significant (p<0.05) and the drop in the cortisol and GH was very significant (p<0.001). Fluorine levels significantly rose during the study (p<0.001), depending on the species, doses and duration of application.