Evaluation of the pathogenicity of Candida zeylanoides in BALB/c mice

Systemic candidiasis is an opportunistic infection caused by Candida species in animals. The purpose of this study was to evaluate the pathogenicity of different doses of Candida zeylanoides in BALB/c mice. Thirty mice were selected in this study. Different doses of the yeast were intravenously inoculated to the animals. At first, clinical signs and survival time of infected mice were recorded. Then both mycological and histological examinations were performed for detection of Candida in different tissues. The results showed that the injection of 1 × 108 cells of C. zeylanoides caused high mortality (group 1). The mortalities occurred within 7-12 days (mean: 9.5 days) in group 2 (inoculated with 2 × 107 yeast) and 15-25 days (mean: 20 days) in group 3 (inoculated with 1 × 107 yeast cells) after infection. The kidneys had the highest burden of yeasts (6 × 104 CFU/g). The results of histological examination showed masses of round to oval budding yeast cells along with a few pseudohyphae in different tissues. These results provide evidence that the pathogenicity of C. zeylanoides is directly related to the inoculum size of the infecting species, representing the highest yeast burden in the kidneys of the infected BALB/c mice. In order to obtain the exact virulence factors in C. zeylanoides, this study should be continued in the future.

Evaluation of the pathogenicity of Candida zeylanoides in BALB/c mice

Systemic candidiasis is an opportunistic infection caused by Candida species in animals. The purpose of this study was to evaluate the pathogenicity of different doses of Candida zeylanoides in BALB/c mice. Thirty mice were selected in this study. Different doses of the yeast were intravenously inoculated to the animals. At first, clinical signs and survival time of infected mice were recorded. Then both mycological and histological examinations were performed for detection of Candida in different tissues. The results showed that the injection of 1 × 108 cells of C. zeylanoides caused high mortality (group 1). The mortalities occurred within 7-12 days (mean: 9.5 days) in group 2 (inoculated with 2 × 107 yeast) and 15-25 days (mean: 20 days) in group 3 (inoculated with 1 × 107 yeast cells) after infection. The kidneys had the highest burden of yeasts (6 × 104 CFU/g). The results of histological examination showed masses of round to oval budding yeast cells along with a few pseudohyphae in different tissues. These results provide evidence that the pathogenicity of C. zeylanoides is directly related to the inoculum size of the infecting species, representing the highest yeast burden in the kidneys of the infected BALB/c mice. In order to obtain the exact virulence factors in C. zeylanoides, this study should be continued in the future.

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Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Vertical transmission of porcine circovirus 2b (PCV2b) to mouse fetuses in maternal uterus by artificial insemination with semen from PCV2b-infected male mouse

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Evaluation of the pathogenicity of Candida zeylanoides in BALB/c mice

Ali Reza KHOSRAVI, Hojjatollah SHOKRI, Donya NIKAEIN

An anatomical and histochemical examination of the pituitary gland of carp (Cyprinus carpio)

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Factors affecting colostrum quality of ewes and immunostimulation

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Relative transit time of chyme between duodenal and jejunal segments of the small intestine of cattle

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Effects of different Fasciola hepatica recombinant proteins on the biochemical and serological responses of experimentally infected sheep

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Relationship between dead pupa removal and season and productivity of honey bee (Apis mellifera, Hymenoptera: Apidae) colonies

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The effect of flashed light on the ultrastructure of the retinal photoreceptor cells in rabbit: a transmission electron microscope study

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Epibulbar melanocytoma in a goat

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The effect of electron beam irradiation on β-glucan content, X-ray diffraction of starch, protein subunit patterns, and in vivo digestibility of barley grain in cockerels

Parvin SHAWRANG, Ali Asghar SADEGHI, Behnam GHORBANI