Endocrine and hematobiochemical profile of lambs raised in a semiarid region with different growth potentials during the postweaning period
This study was conducted for establishment of the relationship of blood variables with growth rate of postweaned lambs. Eight lambs each of fast growth (FG; 11.6 ± 0.5 kg live wt. at weaning) and slow growth (SG; 7.7 ± 0.5 kg live wt. at weaning) were monitored fortnightly for endocrine and hematobiochemical variables along with parasitic load and growth performance. Recording of body weight (BW) and average daily gain (ADG) was performed monthly from birth to 180 days. Triiodothyronine (T3) and thyroxine (T4) were significantly (P < 0.05) higher while thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) were significantly (P < 0.05) lower in FG lambs compared to SG lambs. Blood cell counts, hematocrit, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin were significantly (P < 0.05) higher in FG lambs compared to SG lambs. Except for the birth wt., the BW and ADG of FG lambs were significantly (P < 0.05) higher at all time points. Liver enzymes (alkaline phosphatase and alanine aminotransferase) and triglyceride were significantly (P < 0.05) higher in SG lambs compared to FG lambs. These findings indicate a significant influence of growth rate on peripheral concentrations of endocrine and some hematobiochemical variables in lambs. These selected variables can be used for early identification and culling of slow-growing lambs for better economic return to lamb producers.
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- Etherton TD, Kensinger RS. Endocrine regulation of fetal and
postnatal meat animal growth. J Ani Sci 1984; 59: 511-528.
- Medrano RF, Hua HJ. Advances in thyroid hormones function
relate to animal nutrition. Annals of Thyroid Research 2016; 2:
45-52.
- Clemmons DR. The relative roles of growth hormone and IGF-1 in
controlling insulin sensitivity. J Clin Invest 2004; 113: 25-27.
- Huszenicza GY, Kulcsar M, Rudas P. Clinical endocrinology of
thyroid gland function in ruminants. Vet Med 2002; 47: 199-
210.
- Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu
JL, Ooi GT, Setser J, Frystyk J, Boisclair YR et al. Circulating
levels of IGF-1 directly regulate bone growth and density. J Clin
Invest 2002; 110: 771-781.
- Onasanya GO, Oke FO, Sanni TM, Muhammad AI. Parameters
influencing haematological, serum and bio-chemical references
in livestock animals under different management systems.
Open Journal of Veterinary Medicine 2015; 5: 181-189.
- Hester PY, Muir WM, Craig JV, Albright JL. Group selection
for adaptation to multiple-hen cages: hematology and adrenal
function. Poultry Sci 1996; 75: 1295-1307.
- Engidaw S, Anteneh M, Demis C. Coccidiosis in small
ruminants. Afr J Basic Appl Sci 2015; 7: 311-319.
- Sykes AR, Coop RL. Interaction between nutrition and
gastrointestinal parasitism in sheep. N Z Vet J 2001; 49: 222-
226.
- Dass G, Dige MS, Rout PK. Growth traits of Muzaffarnagari
sheep under semi intensive feeding management. Indian Vet J
2016; 93: 78-80.
- Zarkawi M, Al-Daker AM. Body weight and reproductive
parameters in fast and weak growing Awassi ram lambs during
different age stages. Trop Anim Health Prod 2016; 48: 223-227.
- Marai IFM, El-Darawany AA, Fadiel A, Abdel-Hafez MAM.
Physiological traits as affected by heat stress in sheep—A
review. Small Rumin Res 2007; 71: 1-12.
- Hansen J, Perry B. The Epidemiology, Diagnosis and Control
of Helminth Parasites of Ruminants. Nairobi, Kenya: ILRAD;
1994.
- Ali MH, Norouzian MA, Khadem AA. Performance and
measures of stress in lambs weaned at 45 and 90 days. Iranian J
Applied Ani Sci; 2015: 5: 981-985.
- Pascual-Alonso M, Miranda-de la Lama GC, Aguayo-Ulloa
L, Ezquerro L, Villarroel M, Marín RH, Maria GA. Effect of
postweaning handling strategies on welfare and productive
traits in lambs. J Appl Anim Welf Sci 2015; 18: 42-56.
- Flier JF, Harris M, Hollenberg AN. Leptin, nutrition and the
thyroid: the why, the wherefore, and the wiring. J Clin Invest
2000; 105: 859-861.
- Koluman N, Daskiran I. Effects of ventilation of the sheep
house on heat stress, growth and thyroid hormones of lambs.
Trop Anim Health Prod 2011; 43: 1123-1127.
- Van Kessel AG, Korchinski RS, Laarveld B. Growth and
serum thyroid hormone and insulin-like growth factor I
(IGF-I) responses to natural passive immunization against
somatostatin in the lamb. Can J Anim Sci 1993; 73: 509-516.
- Antunović Z, Novoselec J, Sauerwein H, Mensur V, Šperanda
M. Blood metabolic hormones and leptin in growing lambs.
Poljoprivreda 2010; 16: 29-34.
- Williams CC, Calmes KJ, Fernandez JM, Stanley CC, Lovejoy
JC, Bateman HG, Gentry LR, Gantt DT, Harding GD. Glucose
metabolism and insulin sensitivity in Gulf Coast native and
Suffolk ewes during late gestation and early lactation. Small
Rumi Res 2004; 54: 167-171.
- Lowe WL Jr. Biological actions of the insulin-like growth
factors. In: LeRoith D, ed. Insulin-like Growth Factors:
Molecular and Cellular Aspects. Boca Raton, FL, USA: CRC
Press; 1991. pp. 49-85.
- Fiorotto ML, Schwartz RJ, Delaughter M
C. Persistent IGF-I
overexpression in skeletal muscle transiently enhances DNA
accretion and growth. FASEB J 2003; 17: 59-60.
- Wylie ARG, Chestnutt DMB, Kilpatrick DJ. Growth and carcass
characteristics of heavy slaughter weight lambs: effects of sire
breed and sex of lamb and relationships to serum metabolites
and IGF-1. Ani Sci 1997; 64: 309-318.
- Szabo M, Stachura ME, Paleologos N, Bybee DE, Frohman LA.
Thyrotropin-releasing hormone stimulates growth hormone
release from the anterior pituitary of hypothyroid rats in vitro.
Endocrinology 1984; 114: 1344-1351.
- Medrano JF, Bradford GE. Growth performance and plasma
insulin-like growth factor I concentrations in sheep selected
for high weaning weight. J Ani Sci 1991; 69: 1912-1918.
- Greer KA, Hughes LM, Masternak MM. Connecting serum
IGF-1, body size, and age in the domestic dog. Age 2011; 33:
475-483.
- Norouzian MA, Valizadeh R, Khadem AA, Afzalzadeh
A, Nabipour A. The effects of feeding clinoptilolite on
hematology, performance, and health of newborn lambs. Biol
Trace Elem Res 2010; 137: 168-176.
- Acharya M, Burke JM, Coffey KP, Kegley EB, Miller JE, Huff
GR, Smyth E, Terrill TH, Mosjidis JA, Rosenkrans C Jr. Changes
in hematology, serum biochemistry, and gastrointestinal
nematode infection in lambs fed sericea lespedeza with or
without dietary sodium molybdate. J Ani Sci 2015; 93: 1952-
1961.
- Egbe-Nwiyi TN, Nwaosu SC, Salami HA. Haematological
values of apparently healthy sheep and goats as influenced by
age and sex in arid zone of Nigeria. Afr J Biomed Res 2003;
109-115.
- Cwynar P, Kolacz R, Czerski A. Effect of heat stress on
physiological parameters and blood composition in Polish
Merino rams. Berl Munch Tierarztl Wochenschr 2014; 127:
177-182.
- Gartner RJW, Callow LL, Granzien CK, Pepper PM. Variation
in the concentrations of blood constituents in relation to
handling of cattle. Res Vet Sci 1969; 10: 7-12.
- Al-Saad KM, Al-Sadi HI, Abdul-Majeed MO. Clinical,
hematological, biochemical and pathological studies on zinc
deficiency (hypozincemia) in sheep. Vet Res 2010; 3: 14-20.
- Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou
F, Labrianou I. Platelet distribution width: a simple, practical
and specific marker of activation of coagulation. Hippokratia
2010; 14: 28-32.
- Saleem AM, Zanouny AI, Singer AM. Growth performance,
nutrients digestibility, and blood metabolites of lambs fed diets
supplemented with probiotics during pre- and post-weaning
period. Asian-Australas J Anim Sci 2017; 30: 523-530.
- Maroufyan E, Kasim A, Hashemi SR, Loh TC, Bejo MH.
Change in growth performance and liver function enzymes of
broiler chickens challenged with infectious bursal disease virus
to dietary supplementation of methionine and threonine. Am J
Anim Vet Sci 2010; 5: 20-26.