Effect of ractopamine hydrochloride on growth promotion in guinea pigs ( Cavia porcellus )

  Ractopamine hydrochloride (R) is commonly used in the livestock industry, mainly in pork and beef, to improve feed efficiency and productivity. In the present study, the use of R at different doses (20 ppm, 30 ppm, or 40 ppm) on growth performance and carcass characteristics of guinea pigs (male and female) was explored with a view to achieving greater use of this species for human consumption. Thirty-two clinically healthy guinea pigs at an average age of 5 weeks were used. The daily gain, feed over gain ratio, Kleiber ratio, carcass yield, and muscle thickness of the thigh in millimeters were measured. The results obtained were compared to a control group treated with only purified water, without R. Arithmetically, the measured variables showed benefits in the groups treated with R, with the results of Kleiber ratio and muscle thickness of the right thigh demonstrating statistical significance (P < 0.05). In the present work, the noncastrated males treated with R exhibited a more positive effect than the females (P = 0.006). The results suggest that the use of R as a growth promoter could benefit the productivity of guinea pigs for human consumption.

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  • Hales KE, Shackelford SD, Wells JE, King DA, Pyatt NA, Freetly HC, Wheeler TL. Effects of dietary protein concentration and ractopamine hydrochloride on performance and carcass characteristics of finishing beef steers. J Anim Sci 2016; 94: 2097-2102.
  • Tang C, Liang X, Zhang K, Zhao Q, Meng Q, Zhang J. Residues of ractopamine and identification of its glucuronide metabolites in plasma, urine, and tissues of cattle. J Anal Toxicol 2016; 40: 738-743.
  • Mersman HJ. Overview of the effects of β -adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci 1998; 76: 160-172.
  • Mills SE. Biological basis of the ractopamine response. J Anim Sci 2002; 80 (Suppl. 2): E28-E32.
  • Mills SE, Kissel J, Bidwell CA, Smith DJ. Stereoselectivity of porcine β-adrenergic receptors for ractopamine stereoisomers. J Anim Sci 2003; 81: 122-129.
  • Mills SE, Spurlock ME, Smith DJ. β-Adrenergic receptor subtypes that mediate ractopamine stimulation of lipolysis. J Anim Sci 2003; 81: 662-668.
  • Dunshea FR, King RH, Campbell RG, Sainz RD, Kim YS. Interrelationships between sex and ractopamine on protein and lipid deposition in rapidly growing pigs. J Anim Sci 1993; 71: 2919-2930.
  • Costa-Lima BR, Canto AC, Suman SP, Conte-Junior CA, Silveira ET, Silva TJ. Sex-specific effect of ractopamine on quality attributes of pork frankfurters. Meat Sci 2014; 96: 799- 805.
  • Walker DK, Titgemeyer EC, Johnson DE, Laudert SB, Johnson BJ. Effects of ractopamine and gender on protein turnover in skeletal muscle of implanted steers and heifers. S Afr J Anim Sci 2011; 41: 16-23.
  • Centner TJ, Alvey JC, Stelzleni AM. Beta agonists in livestock feed: status, health concerns, and international trade. J Anim Sci 2014; 92: 4234-4240.
  • Colbert WE, Williams PD, Williams GD. Beta-adrenoreceptor profile of ractopamine HCl in isolated smooth and cardiac muscle tissues of rat and guinea pig. J Pharm Pharmacol 1991; 43: 844-847.
  • Ricke EA, Smith DJ, Feil VJ, Larsen GL, Caton JS. Effects of ractopamine HCl stereoisomers on growth, nitrogen retention, and carcass composition in rats. J Anim Sci 1999; 77: 701-707.
  • Smith DJ, Paulson GD. Growth characteristics of rats receiving ractopamine hydrochloride and the metabolic disposition of ractopamine hydrochloride after oral or intraperitoneal administration. J Anim Sci 1994; 72: 404-414.
  • Pleadin J, Vulic A, Persi N, Terzic S, Andrisic M, Zarkovic I, Sandor K, Perak E, Mihaljevic Z. Accumulation of ractopamine residues in hair and ocular tissues of animals during and after treatment. J Anal Toxicol 2013; 37: 117-121.
  • Kunz M. Estudio comparado de variables corporales y tamaño de camada en cuyes ( Cavia porcellus ) Amerindios (arica) y de laboratorio desde el nacimiento hasta los cuatro meses de edad. Santiago, Chile: DVM, Universidad de Chile, 2003 (in Spanish).
  • Spotorno AE, Valladares JP, Marín JC, Zeballos H. Molecular diversity among domestic guinea-pigs ( Cavia porcellus ) and their close phylogenetic relationship with the Andean wild species Cavia tschudii . Rev Chil Hist Nat 2004; 77: 243-250.
  • Lammers PJ, Carlson SL, Zdorkowski GA, Honeyman MS. Reducing food insecurity in developing countries through meat production: the potential of the guinea pig ( Cavia porcellus ). Renew Agric Food Syst 2009; 24: 155-162.
  • Niba AT, Meutchieye F, Fon D, Laisin AG, Taboh H, Njakoi H, Bela Tomo A, Maass BL, Djikeng A, Manjeli Y. Current situation of cavy production in Cameroon: challenges and opportunities. Livestock Res Rural Dev 2012; 24: 194.
  • Herman YC, Fon Dorothy E, Meutchieye F, Niba AT, Manjeli Y, Djikeng A. Cavies for income generation, manure for the farm and meat for the table. Scholarly Journal of Agricultural Science 2014; 4: 260-264.
  • Montgomery DC. Design and Analysis of Experiments. 8th ed. Hoboken, NJ, USA: John Wiley and Sons, Inc.; 2013.
  • Berry DP, Pryce JE. Feed efficiency in growing and mature animals. In: Proceedings of the 10th World Congress on Genetics Applied to Livestock Production; 2014. Pp. 1-6.
  • Kleiber M. Body size and metabolic rate. Physiol Rev 1947; 27: 511-541.
  • Wilson JM, Gaertner DJ, Marx JO, Hankenson FC. Normative values. In: Suckow MA, Stevens KA, Wilson RP, editors. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. San Diego, CA, USA: Academic Press; 2012. Pp. 1231-1241.
  • Pajares C. Reproducción y Manejo Reproductivo en Cuyes. ( Cavia porcellus ). Revisión bibliográfica. MSc, Universidad Nacional de Cajamarca, Cajamarca, Peru, 2009 (in Spanish).
  • Webster AJ. The energetic efficiency of metabolism. Proc Nutr Soc 1981; 40: 121-128.
  • White CR, Seymour RS. Mammalian basal metabolic rate is proportional to body mass 2/3. P Natl Acad Sci USA 2003; 100: 4046-4049.
  • Wheat JD, Spies HG, Tran CT, Koch BA. Effects of two protein levels on growth rate and feed efficiency of guinea pigs from different inbred lines. J Anim Sci 1963; 22: 670-673.
  • Kolokotrones T, Savage V, Deeds EJ, Fontana W. Curvature in metabolic scaling. Nature 2010; 464: 753-756.