ZBIGNIEW MUSZCZYNSKI, EWA SKOTNICKA, DOROTA JANKOWIAK

Diurnal variations of renal activity in goats

Research was conducted on 12 clinically healthy 4-year-old White Nobel goats. Renal activity examinations were carried out with the use of clearance methods where inulin was used as a testing substance to determine the level of glomerular filtration. The results allowed determination of inulin clearance, endogenic creatinine, sodium, potassium, and chloride levels. Filtered load, tubular resorption, and excretion in urine of sodium, potassium, and chlorides were marked. The research revealed diurnal variations of renal activity in goats. Most of the rhythms' acrophases occur in the phase of activeness between 1200 and 1600 hours. The resorption rhythm of potassium in the renal tubule differs from glomerular filtration by 12 h and its acrophases occur in the resting period. The main reasons for diurnal variations of the electrolyte excretion by kidneys are variations of the glomerular filtration rate. Feeding time does not affect the diurnal variations of renal activity. Due to the circadian glomerular filtration variations, resorption and secretion processes in nephrons, and, in consequence, the changes of the final urine composition, the kidneys lead to the organism's adaptation to changes in the environment and also in the circadian rhythm.

Anahtar Kelimeler:

Goats, diurnal variations, renal activity, glomerular filtration rate

Diurnal variations of renal activity in goats

Keywords:

Goats, diurnal variations, renal activity, glomerular filtration rate,

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Takahashi JS. Molecular neurobiology and genetics of circadian rhythms in mammals. Ann Rev Neurosci 1995; 18: 531–553.
Koopman MG, Koomen GC, Krediet RT, De Moor EA, Hoek FJ, Arisz L. Circadian rhythm of glomerular filtration rate in normal individuals. Clin Sci 1989; 77: 105–110.
Piccione G, Caola G. Biological rhythm in livestock. J Vet Sci 2002; 3: 145–157. 4. Skotnicka E, Muszczynski Z, Dudzinska W, Suska M. A review of the renal system and diurnal variations of renal activity in livestock. Irish Vet J 2007; 60: 161–168.
Refoyo A, Bolterman RJ, Bentley MD, Fiksen-Olsen MJ. Distribution of prostaglandin E (PGE) and prostacyclin (PGI2) production in the canine kidney. Hypertension 1989; 13: 531– 542.
Skotnicka E. Circadian variations of the plasma renin activity (PRA), aldosterone and electrolyte concentrations in blood plasma in pregnant and non-pregnant goats. Comp Biochem Physiol C 2003; 134: 385–395.
Skotnicka E. Diurnal changes of plasma arginine-vasopressin concentration in pregnant and non-pregnant goats (Capra hircus). Acta Vet Brno 2005; 74: 43–49.
Van Acker BA, Koomen GC, Koopman MG, Krediet RT, Arisz L. Discrepancy between circadian rhythms of inulin and creatinine clearance. J Lab Clin Med 1992; 120: 400–403.
Bultasova H, Veselkova A, Brodan V, Pinsker P. Circadian rhythms of urinary sodium, potassium and some agents influencing their excretion in young borderline hypertensives. Endocr Exper 1986; 20: 359–364.
Aslanian NL, Babajan LA, Erinian GZ, Grigorian DZ. Electrolyte’s excretion rhythms in normal individuals. Lab Delo 1989; 55: 21–28.
Aizman RI. Circadian rhythms and time course of adaptive sodium and potassium excretion in rats after nephrectomy. Am J Physiol 1994; 266: 454–460.
Vogel G. Beitrage zur Kenntnis der Nierenphysiologie einiger Haussaugetiere. Zentl Vet Med Beiheft 1962; 3: 117–118 (in German).
Sadjak A, Supanz S, Korsatko W, Erhart U, Muhry F. The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat. Agents Actions 1988; 24: 210–215.
Higashi A, Peters L. A rapid colorimetric method for the determination of inulin in plasma and urine. J Clin Lab Med 1950; 35: 475–483.
Żużewicz K, Kwarecki K, Meller H. Mathematical and statistical analysis of physiological parameters in the context of circadian rhythms. Acta Physiol Pol 1979; 19: 179–185.
Skrzypczak WF, Jankowiak D, Muszczyński Z, Janus K. Diurnal variations in kidney activity in calves. Glomerular filtration. In: 9th Congress PTNW, Olsztyn, Poland; 1992. p. 452 (in Polish).
Koopman MG, Krediet RT, Koomen GC, Strackee J, Arisz L. Circadian rhythm of proteinuria: consequences of the use of urinary protein/creatinine ratios. Nephrol Dial Transpl 1989; 4: 9–14.
Buzio C, Mutti A, Perazzoli F, Alinovi R, Arisi L, Negro A. Protein-induced changes in kidney function depend of time of administration but not on the dietary source. Nephron 1990; 56: 234–241.
Koopman MG, Koomen GC, van Acker BA, Arisz L. Circadian rhythms in glomerular filtration rate and effective renal plasma flow (ERPF) in patients with nephrotic syndrome. Kidney Int 1991; 42: 649–656.
Stribrna J, Brodan V. Kosinorova analyza cirkadiannich rytmu krevniho tlaku a vylucovani elektrolytu u nemocnych s esencialni a renovaskularni hypertenzi. Cas Lek Ces 1991; 120: 1201–1211 (in Czech).
Buzio C, Quaretti P, Arisi L, Negro A, Barani R, Aluati MG. Time-dependent increase of glomerular filtration rate after oral protein load: evidence for diurnal variations in renal response. Scand J Clin Lab Invest 1988; 48: 15–20.
Sirota JH, Baldwin DS, Villarreal H. Diurnal variations of renal function in man. J Clin Invest 1950; 29: 187–194.
Luke DR, Wasan KM, Vadiei K. Lack of circadian variation in renal function in the obese rat: influence of continuous food and water intake. Prog Clin Biol Res 1990; 341: 131–138.
Palm U, Boemcke W, Reinhardt HW. Rhythmicity of urinary sodium excretion, mean arterial blood pressure and heart rate conscious dogs. Am J Physiol 1992; 245: 149–154.
Aizman RJ, Velikanova LH. Renal and extra renal excretion of xenobiotes and electrolytes their stimulation during postnatal development. The development of renal functions and water- salt metabolism in ontogeny. Zbl Pharm Pharmakother Labordiagn 1983; 122: 1299–1306.
Skrzypczak WF, Jankowiak D, Muszczyński Z, Janus K. Diurnal variations in kidney activity in calves. Electrolyte excretion. In: 9th Congress PTNW, Olsztyn, Poland; 1992. p. 453 (in Polish).
Aslanian NL, Grigorian DZ, Arutonian ZS. Seasonal changes of the electrolyte’s excretion parameters and renal activity in women. Lab Delo 1989; 55: 64–71.
Markovitz ME, Rosen JF, Mizruchi M. Circadian rhythms of blood minerals during adolescence. Pediat Res 1984; 18: 456– 460.