Comparative effects of sirolimus-eluting versus bare metal stents on neointimal hyperplasia in balloon-injured external iliac artery of rabbits

The aim of this study was to check effectiveness of drug-eluting stents for prevention of restenosis resulting from neointimal hyperplasia. Twenty-one sirolimus-eluting stents (SESs) and bare metal stents (BMSs; control) were compared by implantation into left and right balloon-injured external iliac arteries of New Zealand White rabbits, respectively. Under general anesthesia and angiography, using 3-mm coronary balloon catheters, stents were successfully deployed. Anticoagulant therapy was not given to any animal. Rabbits were allotted into three groups at 7, 14, and 21 days (7 rabbits in each group). Each stented vessel of sacrificed rabbits was subjected to a resin-embedding technique and methyl methacrylate sections were obtained using a tungsten carbide knife for staining. In histological examination, SESs showed marked reductions in almost all parameters. Morphometric results showed that arteries with SESs had a larger luminal area (P < 0.0001), lower intimal (P < 0.001) and medial (P < 0.001) thickness, and lower intimal index (P < 0.003) as opposed to arteries stented with BMSs. Luminal narrowing in SESs was 0% and reendothelialization was similar in both stented groups (90.48%). SESs showed marked reduction in nonocclusive peristrut fibrin deposition versus BMSs. Thus, the SES was more effective for prevention of restenosis than the BMS in rabbit.

Comparative effects of sirolimus-eluting versus bare metal stents on neointimal hyperplasia in balloon-injured external iliac artery of rabbits

The aim of this study was to check effectiveness of drug-eluting stents for prevention of restenosis resulting from neointimal hyperplasia. Twenty-one sirolimus-eluting stents (SESs) and bare metal stents (BMSs; control) were compared by implantation into left and right balloon-injured external iliac arteries of New Zealand White rabbits, respectively. Under general anesthesia and angiography, using 3-mm coronary balloon catheters, stents were successfully deployed. Anticoagulant therapy was not given to any animal. Rabbits were allotted into three groups at 7, 14, and 21 days (7 rabbits in each group). Each stented vessel of sacrificed rabbits was subjected to a resin-embedding technique and methyl methacrylate sections were obtained using a tungsten carbide knife for staining. In histological examination, SESs showed marked reductions in almost all parameters. Morphometric results showed that arteries with SESs had a larger luminal area (P < 0.0001), lower intimal (P < 0.001) and medial (P < 0.001) thickness, and lower intimal index (P < 0.003) as opposed to arteries stented with BMSs. Luminal narrowing in SESs was 0% and reendothelialization was similar in both stented groups (90.48%). SESs showed marked reduction in nonocclusive peristrut fibrin deposition versus BMSs. Thus, the SES was more effective for prevention of restenosis than the BMS in rabbit.

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Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Comparing levels of certain heavy metals and minerals and antioxidative metabolism in cows raised near and away from highways

Meryem EREN, Özkan ŞİMŞEK, Şevket ARIKAN, Bayram GÜNER, Hüsamettin EKİCİ

Novel coproducts from corn milling and their use in ruminants? nutrition

CATALIN DRAGOMIR, MARKETTA RINNE, DAVID YANEZ-RUIZ

The genetic diversity of both FecB gene and microsatellite GC101is associated with reproduction selection in sheep

ZHANGYUAN PAN, BAOYUN ZHANG, WENPING HU, RAN DI, QIUYUE LIU, XIANGYU WANG, DEHUA YIN, PINGQING WANG, MINGXING CHU

Comparative effects of sirolimus-eluting versus bare metal stents on neointimal hyperplasia in balloon-injured external iliac artery of rabbits

Atul PATEL, Pinesh PARIKH, Deepak PATIL, Anila MATHEW, Suhas LELE, Mohan RAJAPURKAR, Pradip PATIL, Akhilesh KUMAR, Priti VANI

The effect of diferent body weight categories on plasma macromineral levels in four close-bred focks of adult Japanese quails ( Coturnix coturnix japonica )

Ahmed Sultan JATOI, Abdul Waheed SAHOTA, Yassar ABBAS, Amjad Hussain MIRANI, Hafz Muhammad ISHAQ, Khalid JAVED, Muhammad Hayat JASPAL, Jibran HUSSAIN, Shahid MEHMOOD, Muhammad AKRAM

Comparison of in vitro and in vivo antibacterial efficacy for the control of Flavobacterium psychrophilum in rainbow trout (Oncorhynchus mykiss)fry: the first genotypical evidence in West Aegean region of Turkey

MURAT BOYACIOĞLU, CAVİT KUM, ŞÜKRÜ KIRKAN, SELİM SEKKİN, UĞUR PARIN, ÜMİT KARADEMİR, FERDA AKAR

Comparison of in vitro and in vivo antibacterial efcacy for the control of Flavobacterium psychrophilum in rainbow trout ( Oncorhynchus mykiss) fry: the frst genotypical evidence in West Aegean region of Turkey

Murat BOYACIOĞLU, Cavit KUM, Ferda AKAR, Uğur PARIN, Şükrü KIRKAN, Selim SEKKİN, Ümit KARADEMİR

Efficacy of experimental inactivated and live Rhodococcus equivaccines for thoroughbred Arabian mares in mice

OSMAN ERGANİŞ, HASAN HÜSEYİN HADİMLİ, ZAFER SAYIN, ASLI SAKMANOĞLU, YASEMİN PINARKARA, ÖZGÜR ÖZDEMİR

Relationships of fatty acid group contents in milk and reproductiveperformance in Holstein cows

Jaromネr DUCHÁCEK, Jan BERAN, Martin PTÁCEK, Ludek STÁDNÍK, Monika OKROUHLA, Renata TOUSOVÁ, Martina DOLEZALOVA

The relationships between Brucella melitensis predilection sites, bacterial loads in vivo, and the agglutinating antibody response in experimentally infected sheep

XIAOLEI GAO, YU KUANG, LINTAO MA, YANLI LU, QINGMIN WU