Changes in Some Blood Biochemical and Haematological Parameters in Goats after Aminoglycoside and Aminocyclitol Treatment at Therapeutic Doses
The aim of the present study was to determine the changes in some blood biochemical and haematological parameters in healthy female goats after a 5-day parenteral treatment with gentamicin (4 mg/kg), tobramycin (5 mg/kg), amikacin (10 mg/kg), kanamycin (10 mg/kg), apramycin (20 mg/kg), and spectinomycin (20 mg/kg). The results indicated that aminoglycosides caused more severe alterations than aminocyclitols, especially on those parameters related to renal function. There was a tendency toward a rise in plasma creatinine and urea levels after aminoglycoside treatment, as well as a rise in urea levels after aminocyclitol administration. These antibiotics caused decreases in plasma or serum glucose, sodium and chloride levels, erythrocytes and leukocytes counts, haematocrit percentage and haemoglobin concentration. For plasma or serum total protein, total lipids, lactate dehydrogenase, alkaline phosphatase, calcium, and magnesium concentrations and differential white blood cell counts, various changes occurred. As a whole, these antibiotics have the potential to alter biochemical and haematological values in female goats after their use at therapeutic doses.
Changes in Some Blood Biochemical and Haematological Parameters in Goats after Aminoglycoside and Aminocyclitol Treatment at Therapeutic Doses
The aim of the present study was to determine the changes in some blood biochemical and haematological parameters in healthy female goats after a 5-day parenteral treatment with gentamicin (4 mg/kg), tobramycin (5 mg/kg), amikacin (10 mg/kg), kanamycin (10 mg/kg), apramycin (20 mg/kg), and spectinomycin (20 mg/kg). The results indicated that aminoglycosides caused more severe alterations than aminocyclitols, especially on those parameters related to renal function. There was a tendency toward a rise in plasma creatinine and urea levels after aminoglycoside treatment, as well as a rise in urea levels after aminocyclitol administration. These antibiotics caused decreases in plasma or serum glucose, sodium and chloride levels, erythrocytes and leukocytes counts, haematocrit percentage and haemoglobin concentration. For plasma or serum total protein, total lipids, lactate dehydrogenase, alkaline phosphatase, calcium, and magnesium concentrations and differential white blood cell counts, various changes occurred. As a whole, these antibiotics have the potential to alter biochemical and haematological values in female goats after their use at therapeutic doses.
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- Lashev, L., Lasarova, S.: Pharmacokinetics and side-effects of gentamicin in healthy and Pseudomonas aeruginosa infected sheep. J. Vet. Pharmacol. Ther., 2001; 24: 237-240. 2.
- Gilbert, D.N., Plamp, C., Starr, P., Bennett, W.M., Houghton,
- D.C., Porter, G.: Comparative nephrotoxicity of gentamicin and
- Godber, L.M., Walker, R.D., Stein, G.E., Hauptman, J.G.,
- Derksen, F.J.: Pharmacokinetics, nephrotoxicosis, and in vitro
- antibacterial activity associated with single versus multiple (three
- times) daily gentamicin treatments in horses. Am. J. Vet. Res., 1995; 56: 613-618.
- Jernigan, A.D., Hatch, R.C., Brown J., Crowell, W.A.: Pharmacokinetic and pathological evaluation of gentamicin in cats given a small intravenous dose repeatedly for five days. Can. J. Vet. Res., 1988; 52: 177-180.
- Yazar, E., Elmas, M., Altunok, V., Sivrikaya, A., Oztekin, E., Birdane, Y.O.: Effects of aminoglycoside antibiotics on renal antioxidants, malondialdehyde levels, and some serum biochemical parameters. Can. J. Vet. Res., 2003; 67: 239-240.
- Sumano, H., Gutierrez, L., Velazquez C., Hayashida, S.: Pharmacokinetics and renal toxicity of three once-a-day doses of amikacin in cows. Acta Vet. Hung., 2005; 53: 231-240.
- Albarellos, G., Montoya, L., Ambros, L., Kreil, V., Hallu R., Rebuelto, M.: Multiple once-daily dose pharmacokinetics and renal safety of gentamicin in dogs. J. Vet. Pharmacol. Ther., 2004; 27: 21-25.
- Nieminen, L., Kasanen A., Kangas L., Sairio E., Anttila, M.: Renal accumulation of amikacin, tobramycin and gentamicin in the rat. Cell. Mol. Life Sci., 1978; 34: 1335-1336.
- Georgiev, I., Georgieva, T., Georgiev, G.: Endocrine Control of Lactation. KOTA, Stara Zagora, 2002; 180-181.
- Nikolov, Y., Petkov, P., Tsokova, L., Sabev, S., Binev, R.: Manual of Propaedeutics of Internal Noninfectious Diseases in Domestic Animals. SD Kontrast, Stara Zagora, 2003, 55-56.