Gabriela SILVA-HIDALGO, Silvia Del Carmen COTA-GUAJARDO, Margarita Del Socorro DÁVILA-PAREDES, Nora María CÁRCAMO-ARÉCHIGA, Martin LÓPEZ-VALENZUELA

Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

Öz A male mixed breed street dog (age unknown) presented with an ocular mass and multiple ulcerated subcutaneous nodules on both hind limbs which bled easily when touched. Inspection of the genital organs revealed that no masses were present. The ocular mass and nodules were diagnosed as a transmissible venereal tumor (TVT) by fine-needle aspiration cytology. The total remission of the tumor was achieved after 5 applications of vincristine sulfate. The dog was adopted during the remission period, but 5 months after adoption he developed neurological signs and died. The necropsy revealed a mass located in the trunk of the corpus callosum of the right hemisphere of the brain. The cytological, histological, and PCR findings of the brain mass were consistent with a TVT. These findings highlight the need to consider the aggressive metastatic potential of canine TVT, even after apparently effective chemotherapy.

Anahtar Kelimeler:

Cerebral, dog, metastases, TVT, vincristine

Tam Metin

Kaynakça

1. Strakova A, Murchison EP. The changing global distribution and prevalence of canine transmissible venereal tumor. BMC Veterinary Research 2014; 10 (168): 1-10. doi: 10.1186/s12917- 014-0168-9

2. Mendoza VN, Chavera CA, Falcón PN, Perales CR. Frequency of the transmissible venereal tumor in dogs: caseload in the pathology laboratory of the National University of San Marcos (Period 1998-2004). Revista de Investigaciones Veterinarias del Perú 2010; 21 (1): 42-47 (in Spanish with an abstract in English).

3. Grandez RR, de Priego CM, Yi AP, Torres PL. Extragenital transmissible venereal tumor: retrospective study of 11 cases. Revista de Investigaciones Veterinarias del Perú 2011; 22 (4): 342-350 (in Spanish with an abstract in English).

4. Pineda CJ, Romero NC, Mendoza MGD, García CCA, Plata F et al. Canine transmissible venereal tumor in the metropolitan area of Mexico city. Revista Científica FCV-LUZ 2010; 20 (4): 362-366 (in Spanish with an abstract in English).

5. Couto do Amaral AV, de Oliveira FR, da Silva MAP, Leao BM, da Costa L et al. Intraocular transmisible venereal tumor in a dog case report. Veterinaria e Zootecnia 2012; 19 (1): 79-85 (in Portuguese with an abstract in English).

6. Rezaei MS, Azizi S, Shahheidaripour S, Rostami S. Primary oral and nasal transmissible venereal tumor in a mix-breed dog. Asian Pacific Journal of Tropical Biomedicine 2016; 6 (5): 443-445. doi: 10.1016/j.apjtb.2016.03.006

7. Barbalho LT, Tertuliano MPV, Lira RN, Jark PC, Passino MJF et al. Canine transmissible venereal tumor in a dog with single extragenital location. Veterinaria e Zootecnia 2013; 20 (1): 57- 61 (in Portuguese with an abstract in English).

8. Pinczowski P, Gimeno M, Aceña C, Villegas A, de Martino A et al. Brain metastasis in a case of canine transmissible venereal tumor after a supposed successful treatment with vincristine sulfate. Acta Veterinaria-Beograd 2015; 65 (1): 137-142. doi: 10.1515/acve-2015-0011

9. Ferreira AJA, Jaggy A, Varejao AP, Ferreira MLP, Correia JMJ et al. Brain and ocular metastases from a transmissible venereal tumour in a dog. Journal of Small Animal Practice 2000; 41 (4): 165-168. doi: 10.1111/j.1748-5827.2000.tb03187.x

10. Chikweto A, Kumtheka S, Larkin H, Deallie C, Tiwari KP et al. Genital and extragenital canine transmissible venereal tumor in dogs in Granada, West Indies. Open Journal of Veterinary Medicine 2013; 3 (2): 111-114. doi: 10.4236/ojvm.2013.32018

11. Chandrasekar M, Pothiappan P, Balachandran C. Therapeutic management of cutaneous transmissible venereal tumors without genital involvement in a dog. Intas Polivet 2013; 14 (2): 481-482.

12. Setthawongsin C, Techangamsuwan S, Tangkawattana S, Rungsipipat A. Cell-based polymerase chain reaction for canine transmissible venereal tumor (CTVT) diagnosis. Journal of Veterinary Medical Science 2016; 78 (7): 1167-1173. doi: 10.1292/jvms.15-0710

13. Purohit G. Canine transmissible venereal tumor: a review. Internet Journal of Veterinary Medicine 2009; 6 (1): 1-7.

14. Pai CC, Kuo TF, Mao SJ, Chuang TF, Lin CS et al. Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid. Veterinary Immunology and Immunopathology 2011; 139 (2-4): 187-199. doi: 10.1016/j. vetimm.2010.10.013

Kaynak Göster

Bibtex	@araştırma makalesi { tbtkveterinary699704, journal = {Turkish Journal of Veterinary and Animal Sciences}, issn = {1300-0128}, eissn = {1303-6181}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {162 - 166}, doi = {}, title = {Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog}, key = {cite}, author = {Sılva-hıdalgo, Gabriela and Cota-guajardo, Silvia Del Carmen and Dávıla-paredes, Margarita Del Socorro and Cárcamo-aréchıga, Nora María and López-valenzuela, Martin} }
APA	Sılva-hıdalgo, G , Cota-guajardo, S , Dávıla-paredes, M , Cárcamo-aréchıga, N , López-valenzuela, M . (2020). Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog . Turkish Journal of Veterinary and Animal Sciences , 44 (1) , 162-166 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkveterinary/issue/52919/699704
MLA	Sılva-hıdalgo, G , Cota-guajardo, S , Dávıla-paredes, M , Cárcamo-aréchıga, N , López-valenzuela, M . "Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog" . Turkish Journal of Veterinary and Animal Sciences 44 (2020 ): 162-166 <https://dergipark.org.tr/tr/pub/tbtkveterinary/issue/52919/699704>
Chicago	Sılva-hıdalgo, G , Cota-guajardo, S , Dávıla-paredes, M , Cárcamo-aréchıga, N , López-valenzuela, M . "Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog". Turkish Journal of Veterinary and Animal Sciences 44 (2020 ): 162-166
RIS	TY - JOUR T1 - Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog AU - Gabriela Sılva-hıdalgo , Silvia Del Carmen Cota-guajardo , Margarita Del Socorro Dávıla-paredes , Nora María Cárcamo-aréchıga , Martin López-valenzuela Y1 - 2020 PY - 2020 N1 - DO - T2 - Turkish Journal of Veterinary and Animal Sciences JF - Journal JO - JOR SP - 162 EP - 166 VL - 44 IS - 1 SN - 1300-0128-1303-6181 M3 - UR - Y2 - 2019 ER -
EndNote	%0 Turkish Journal of Veterinary and Animal Sciences Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog %A Gabriela Sılva-hıdalgo , Silvia Del Carmen Cota-guajardo , Margarita Del Socorro Dávıla-paredes , Nora María Cárcamo-aréchıga , Martin López-valenzuela %T Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog %D 2020 %J Turkish Journal of Veterinary and Animal Sciences %P 1300-0128-1303-6181 %V 44 %N 1 %R %U
ISNAD	Sılva-hıdalgo, Gabriela , Cota-guajardo, Silvia Del Carmen , Dávıla-paredes, Margarita Del Socorro , Cárcamo-aréchıga, Nora María , López-valenzuela, Martin . "Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog". Turkish Journal of Veterinary and Animal Sciences 44 / 1 (Şubat 2020): 162-166 .
AMA	Sılva-hıdalgo G , Cota-guajardo S , Dávıla-paredes M , Cárcamo-aréchıga N , López-valenzuela M . Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(1): 162-166.
Vancouver	Sılva-hıdalgo G , Cota-guajardo S , Dávıla-paredes M , Cárcamo-aréchıga N , López-valenzuela M . Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(1): 162-166.
IEEE	G. Sılva-hıdalgo , S. Cota-guajardo , M. Dávıla-paredes , N. Cárcamo-aréchıga ve M. López-valenzuela , "Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog", Turkish Journal of Veterinary and Animal Sciences, c. 44, sayı. 1, ss. 162-166, Şub. 2020