Hasan GHAHRI, Alireza TALEBI, Mohamad CHAMANI

Ameliorative effect of esterified glucomannan, sodium bentonite, and humic acid on humoral immunity of broilers during chronic aflatoxicosis

A study was conducted on the impact of aflatoxin (AF) and mycotoxin binders on immunization against Infectious Bursal Disease (IBD) and Infectious Bronchitis (IB) in chickens. Broiler chicks (7-day-old) were randomly assigned to 9 dietary treatments with 4 replicates of 12 chicks each. Treatments were 1) control; 2) diet containing corn naturally contaminated with AF (NCD); 3) NCD + 0.2% Farmagülatör DRYTM humate (FH); 4) NCD + 0.4% FH; 5) NCD + 0.6% FH; 6) NCD + 0.8% FH; 7) NCD + 1% FH; 8) NCD + 0.5% sodium bentonite (SB); and 9) NCD + 0.1% esterified glucomannan (E-GM). Data were evaluated with ANOVA for a complete randomized design, using the general linear models procedure of SAS software. Compared to control diet; the antibody titers of IB and IBD were significantly lower in the 254 ppb aflatoxin fed chicks from 28 to 35 days of age. The addition of E-GM, SB, and FH to the aflatoxin-containing diet significantly ameliorated the adverse effects of aflatoxin on IBD and IB antibody titers, but FH supplementation to the contaminated diet with aflatoxin proved to be much more effective in the amelioration of the adverse effect of aflatoxin on humoral immunity against IB.

Anahtar Kelimeler:

Key words: AFB1, esterified glucomannan, sodium bentonite, humic acid, broiler chicks, humoral immunity

Ameliorative effect of esterified glucomannan, sodium bentonite, and humic acid on humoral immunity of broilers during chronic aflatoxicosis

Keywords:

Key words: AFB1, esterified glucomannan, sodium bentonite, humic acid, broiler chicks, humoral immunity,

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(31). In the present study the addition of Na-bentonite
was effective in ameliorating the negative effect of AF
on antibody production. The ameliorative effect of
dietary Na-bentonite on the reduced antibody titers
caused by AF could be attributed to the role of Na
bentonite as a sequestering agent of AF in the
gastrointestinal tract. These results clearly
demonstrated that the 254 ppb AF-treatment
signiŞcantly affected the humoral immunity against
IB and IBD, and the simultaneous addition of humic
acid to the AF-containing diet provided signiŞcant
reduction on the immunotoxic effects of AF. These
improvements should contribute to a solution of the
AF problem in broiler chickens, when used with
mycotoxin management practices.