Sun Protective Potential and Physical Stability of Herbal Sunscreen Developed from Afghan Medicinal Plants

Objectives: The aim of this study was to develop an herbal topical sunscreen formulation based on some fixed oils in combination with somemedicinal plants.Materials and Methods: The crude and purified extracts were screened for their phytochemical profile and their sun protection potentials. Based onour results, Elaeagnus angustifolia purified extract (EAPE), sesame oil, and sea buckthorn oil were selected for the development of the sunscreenformulation. The developed sunscreen formulations containing different concentration of EAPE were evaluated for their different physicochemicalproperties and stability.Results: The results of the phytochemical analysis revealed the presence of phenolic compounds and flavonoids in all tested extracts. EAPE,sesame oil, and sea buckthorn oil showed the highest absorption in the ultraviolet region. The sun protection factor (SPF) value of the developedformulations containing different concentration of EAPE was in the range of 6.37±0.14 to 21.05±0.85. The sunscreen formulation containing 6%EAPE was stable for 8 weeks in an oven (40 °C) and refrigerator (4 °C).Conclusion: The findings of this study revealed a higher sun protection capacity of EAPE than the other plant extracts. Sunscreen formulationscontaining 6% EAPE showed promising SPF values. However, further in vivo studies are highly recommended to prove further the safety andefficacy of our developed sunscreen formulation.

Afgan Tıbbi Bitkilerinden Geliştirilen Bitkisel Güneş Koruyucunun Güneş Koruyucu Potansiyeli ve Fiziksel Stabilitesi

Amaç: Bu çalışmanın amacı, bazı tıbbi bitkiler ve sabit yağlar kullanılarak bir bitkisel güneş koruyucu geliştirmektir. Gereç ve Yöntemler: Sabit yağların ham ve saflaştırılmış ekstreleri, fitokimyasal profilleri ve güneş koruma potansiyelleri açısından taranmıştır. Elde edilen sonuçlara dayanarak, güneş koruyucu formülasyonunun geliştirilmesi için Elaeagnus angustifolia saflaştırılmış ekstresi (EAPE), susam yağı ve yabani iğde yağı seçilmiştir. Farklı EAPE konsantrasyonları içeren geliştirilmiş güneş koruyucu formülasyonlar, farklı fizikokimyasal özellikleri ve stabiliteleri açısından değerlendirilmiştir. Bulgular: Fitokimyasal analizler, test edilen tüm ekstrelerde fenolik bileşiklerin ve flavonoitlerin varlığını göstermiştir. EAPE, susam yağı ve yabani iğde yağı, ultraviyole bölgede en yüksek absorbsiyon göstermiştir. Farklı EAPE konsantrasyonları içeren geliştirilmiş formülasyonların güneş koruma faktörü (SPF) değerlerinin, 6,37±0.14 ile 21,05±0,85 aralığında olduğu bulunmuştur. Geliştirilen 6% EAPE içeren güneş koruyucu formülasyonunun kurutma fırınında (40 °C) ve buzdolabında (4 °C) 8 hafta süresince stabil olduğu tespit edilmiştir. Sonuç: Bu çalışmanın bulguları, EAPE’nin diğer bitki ekstrelerden daha yüksek güneş koruma kapasitesine sahip olduğunu göstermiştir. %6 EAPE içeren güneş koruyucu formülasyonun umut verici bir SPF değerine sahip olduğu bulunmuştur. Bununla birlikte sonuçlara göre geliştirdiğimiz güneş koruyucu formülasyonun güvenilirliğini ve etkinliğini kanıtlamak için ek in vivo çalışmaların yapılması oldukça önemlidir.

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Turkish Journal of Pharmaceutical Sciences
  • ISSN: 1304-530X
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 2000

6.6b293

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