Anatolii MATVIYCHUK, Galina SLIPCHENKO, Yurii STOLETOV, Galina BELIK, Olena RUBAN, Sergii KUTSENKO

Comparative Characteristics of Anti-depressant, Anti-hypoxic Action, and Effect on the Physical Endurance of Scutellaria baicalensis Drugs

Objectives: The influence of original drugs from Scutellaria baicalensis (SB) Georgi (dry extract, powder of rhizomes and roots, tablets “Scutex” onthe basis of the dry extract and capsules “Scutella”, which contain powder of rhizomes with roots) was studied on depressive behavior, physicalendurance and anti-hypoxic activity in mice.Materials and Methods: The used dry extract SB (SBDE), powder of roots and rhizomes from SB (SBRP), tablets from dry extract of SB named“Scutex”, and hard gelatin capsules from the crushed root of SB named “Scutella” were obtained from National University of Pharmacy, Departmentof Industrial Technology of Drugs. In the experiment, 94 random-breed white male mice weighing 20-29 g were used and kept in standard sanitaryand laboratory conditions.Results: The experiments revealed that SBDE had anti-depressant action. Powder from rhizomes and roots of SB and “Scutella” capsules hadanti-hypoxic action. All test drugs showed no influence on the physical endurance of mice. These results suggest the possible use of SBDE as ananti-depressant drug, and rhizomes with roots and “Scutella” capsules as an anti-hypoxic remedy.Conclusion: SBDE at a dose 50 mg/kg shows anti-depressant activity that exceeds the activity of the comparison drug “Bilobil”. SBDE, SBRP,“Scutex” tablets and “Scutella” capsules do not affect the physical endurance of mice. SBDE at a dose 50 mg/kg and SBRP at a dose of 173 mg/kg and 260 mg/kg exhibit anti-hypoxic activity. “Scutex” tablets show no anti-hypoxic action and “Scutella” capsules cause probable anti-hypoxicaction that exceeds the effect of the reference drug “Bilobil”

Scutellaria baicalensis (Çin Takkesi) İlaçlarının Anti-Depresan, Anti-Hipoksik ve Fiziksel Dayanıklılık Üzerine Etkilerinin Karşılaştırmalı Özellikleri

Amaç: Orijinal Scutellaria baicalensis (SB) Georgi ilaçlarının (kuru ekstresi, rizom ve kök tozları, kuru ekstre bileşimli “Scutex” tabletleri ve rizom ve kök tozu taşıyan “Scutella” kapsülleri) depresif davranış, fiziksel dayanıklılık ve anti-hipoksik aktivite üzerine etkisi sıçanlar üzerinde test edilmiştir. Deneyler, SB’nin kuru ekstresinin anti-depresan etkiye sahip olduğunu ortaya koymuştur. Gereç ve Yöntemler: SB kuru ekstresi (SBDE), SB köklerinden (SBRP) ve rizomlarından elde edilen toz, “Scutex” kodlu SB’nin kuru ekstresinden elde edilen tabletler ve “Scutella” kodlu SB’nin ezilmiş kökünden elde edilen sert jelatin kapsüller, Ulusal Eczacılık Üniversitesi, İlaçların Endüstriyel Teknolojisi Anabilim Dalı’nda hazırlandı. Deneyde 20-29 g ağırlığındaki, rastgele-ırk, beyaz erkek sıçanlar kullanıldı ve standart sağlık ve laboratuvar koşullarında tutuldu. Bulgular: Deneyler SB’nin kuru ekstresinin anti-depresan etkiye sahip olduğunu ortaya çıkarmıştır. SB rizom ve kök tozunun ve “Scutella” kapsüllerinin anti-hipoksik etkisi vardır. Test edilen ilaçlardan hiçbiri sıçanların fiziksel dayanıklılığı üzerinde etki göstermemiştir. Bu sonuçlar, SB’nin kuru ekstresinin anti-depresan ilaç, kök, rizomlar ve “Scutella” kapsüllerinin anti-hipoksik ilaç olarak kullanımını önermektedir. Sonuç: SBDE 50 mg/kg’lık bir dozda, karşılaştırma ilacı “Bilobil” etkisini aşan anti-depresan aktivite gösterir. SBDE, SBRP, “Scutex” tabletleri ve “Scutella” kapsülleri sıçanların fiziksel dayanıklılığını etkilemez. SBDE, 50 mg/kg dozunda ve SBRP’de 173 mg/kg ve 260 mg/kg dozunda antihipoksik aktivite gösterir. “Scutex” tabletleri anti-hipoksik etki göstermez ve “Scutella” kapsülleri referans ilaç “Bilobil” etkisini aşan muhtemel anti-hipoksik etkilere neden olur.

Tam Metin

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