Mandar BHATTACHARYA, Pranami BHAUMİK, Subrata Kumar DEY

Telomere length comparison between oral cells and blood cells among neonates

Telomere length, measured from blood cells, is commonly used as the standardtelomere length of the whole body. The relationship between blood telomerelength and oral telomere length is still unclear, especially among neonates. Inthis study, we measured blood telomere length as well as cheek cells telomerelength to find out the overall telomere synchronization in neonates. Childrenaged 1 month or younger were included in this study. Blood and cheek cells werecollected by heel stick method and nylon brush accordingly. Telomere lengthwas measured by Southern blotting. A strong telomere length correlation(0.77, p

PDF

___

1. Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer. Hum Mol Genet 2001; 10: 677-685.

2. Mather KA, Jorm AF, Parslow RA, Christensen H. Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci 2011; 66: 202-213.

3. Daniali L, Benetos A, Susser E, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun 2013; 4: 1597.

4. Kroenke CH, Epel E, Adler N, et al. Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosom Med 2011; 73: 533-540.

5. Howie SR. Blood sample volumes in child health research: review of safe limits. Bull World Health Organ 2011; 89: 46-53.

6. Benetos A, Okuda K, Lajemi M, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001; 37(2 Pt 2): 381-385.

7. Okuda K, Bardeguez A, Gardner JP, et al. Telomere length in the newborn. Pediatr Res 2002; 52: 377- 381.

8. Dlouha D, Maluskova J, Kralova Lesna I, Lanska V, Hubacek JA. Comparison of the relative telomere length measured in leukocytes and eleven different human tissues. Physiol Res 2014; 63(Suppl 3): S343-S350.

9. Youngren K, Jeanclos E, Aviv H, et al. Synchrony in telomere length of the human fetus. Hum Genet 1998; 102: 640-643.

10. Gardner JP, Kimura M, Chai W, et al. Telomere dynamics in macaques and humans. J Gerontol A Biol Sci Med Sci 2007; 62:367-374.

11. Benetos A, Kimura M, Labat C, et al. A model of canine leukocyte telomere dynamics. Aging Cell 2011;10: 991-995.

12. Reichert S, Criscuolo F, Verinaud E, Zahn S, Massemin S. Telomere length correlations among somatic tissues in adult zebra finches. PLoS One 2013; 8: e81496.

13. Karlsson AO, Svensson A, Marklund A, Holmlund G. Estimating human age in forensic samples by analysis of telomere repeats. Forensic Sci Int: Genet Suppl Ser 2008; 1: 569-571.

14. Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 1998; 95: 5607- 5610.

15. Thiede C, Prange-Krex G, Freiberg-Richter J, Bornhäuser M, Ehninger G. Buccal swabs but not mouthwash samples can be used to obtain pretransplant DNA fingerprints from recipients of allogeneic bone marrow transplants. Bone Marrow Transplant 2000; 25: 575-577.

16. Kostjukovits S, Degerman S, Pekkinen M, et al. Decreased telomere length in children with cartilagehair hypoplasia. J Med Genet 2017; 54: 365-370.

17. Gruszecka A, Kopczyński P, Cudziło D, et al. Telomere shortening in Down syndrome patients--when does it start? DNA Cell Biol 2015; 34: 412-417.

18. Anderson ER, Mayes LC. Race/ethnicity and internalizing disorders in youth: a review. Clin Psychol Rev 2010; 30: 338-348.

19. Orth U, Robins RW, Widaman KF, Conger RD. Is low self-esteem a risk factor for depression? Findings from a longitudinal study of Mexican-origin youth. Dev Psychol 2014; 50: 622-633.

20. Feder A, Alonso A, Tang M, et al. Children of lowincome depressed mothers: psychiatric disorders and social adjustment. Depress Anxiety 2009; 26: 513- 520.

21. Mitchell C, Hobcraft J, McLanahan SS, et al. Social disadvantage, genetic sensitivity, and children's telomere length. Proc Natl Acad Sci U S A 2014; 111: 5944-5949.

22. Drury SS, Theall K, Gleason MM, et al. Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatry 2012; 17:719-727.