Selda HANÇERLİ TÖRÜN, Meral ÇIPLAK, Deniz ÖZÇEKER, Metin UYSALOL, Agop ÇITAK, ZEYNEP ÜLKER TAMAY, Nuran SALMAN, Nermin GÜLER, Günülü ŞIK, Ayper SOMER

Predictive factor for first wheezing episode

The aim of study was to evaluate various risk in patients who were hospitalized with moderate to severe virus-induced wheezing. Infants hospitalized with virus-induced wheezing were enrolled in the study. Respiratory viruses were detected in nasopharyngeal swab and total IgE levels and skin prick tests were performed in all patients. The mean age of the patients was 11.2±9 months. The most common detected viral agents were Respiratory Syncytial Virus, (33.6%), Influenza virus (16.3.%). Children with positive family history of atopy had their first virus-induced wheezing at an earlier age (9.0 ±7.8 months) than the others (14.2±10.8 months), (p=0.007). Atopy and viral etiology did not significantly influence clinical severity of the disease. Although children with positive parental history of atopy experience first virus-induced wheezing at an earlier age, personal atopy was not found as a risk factor for predicting the severity of the first virus-induced wheezy episode.

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1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ, Group Health Medical Associates. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332: 133.

2. Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy 2010; 40: 1130.

3. Lodge CJ, Zaloumis S, Lowe AJ, et al. Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. J Pediatr 2014; 164: 289-294.

4. Bessa OA, Leite ÁJ, Solé D, Mallol J. Prevalence and risk factors associated with wheezing in the first year of life. J Pediatr 2014; 90(2): 190-196.

5. Wright AL. Epidemiology of asthma and recurrent wheeze in childhood. Clin Rev Allergy Immunol. 2002; 22: 33-44.

6. Bronchiolitis Guideline Team, Cincinnati Children’s Hospital Medical Center. Bronchiolitis pediatric evidence-based care guidelines, 2010. http://www. cincinnatichildrens.org/service/j/anderson-center/ evidence-based-care/bronchiolitis/ (Accessed on November 08, 2014).

7. Scottish Intercollegiate Guidelines Network. Bronchiolitis in children. A national clinical guideline.

2006. http://www.sign.ac.uk/pdf/sign91.pdf 8. Fitzgerald DA, Kilham HA. Bronchiolitis:assessment and evidence-based management. MJA 2004; 180: 399-404.

9. Bialy L,Smith M,Bourke T, Becker L. The Cochrane Library and brınchiolitis:an umbrella review. Evid-Based Child Health I 2006; 939-947.

10. Heymann PW, Carper HT, Murphy DD, et al.Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. RJ Allergy Clin Immunol 2004; 114: 239-247.

11. Rona RJ, Gulliford MC, Chinn S. Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood. BMJ 1993; 306: 817-820.

12. Brew BK, Allen CW, Toelle BG, Marks GB. Systematic review and meta-analysis investigating breast feeding and childhood wheezing illness. Paediatr Perinat Epidemiol 2011; 25: 507-518.

13. Jeong Y, Jung-Choi K, Lee JH, Lee HY, Park EA, Kim YJet al. Body weight at birth and at age three and respiratory illness in preschool children. J Prev Med Public Health 2010; 43: 369-376. 14. Douglas RG Jr, Alford BR, Couch RB. Atraumatic nasal biopsy for studies of respiratory virus infection in volunteers. Antimicrob Agents Chemother 1968; 8: 340. 15. Uyar M, Kuyucu N, Tezcan S, Aslan G, Tasdelen B. Determination of the frequency of human bocavirus and other respiratory viruses among 0-2 years age group children diagnosed as acute bronchiolitis. Mikrobiyol Bul 2014; 48: 242-258.

16. Fujitsuka A, Tsukagoshi H, Arakawa M, et al. A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness. BMC Infect Dis 2011; 11: 168.

17. García-García ML, Calvo C, Falcón A, et al. Role of emerging respiratory viruses in children with severe acute wheezing. Pediatr Pulmonol 2010; 45: 585-591.

18. Young S, Le Souef PN, Geelhold GC, Stick SM, Turner KJ, Landau LI. The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. N Eng J Med 1991; 324: 1168-1173.

19. Meral Ciplak, Grip Platformu. Influenza vaccination in Turkey: Prevalence of risk groups, current vaccination status, factors influencing vaccine uptake and steps taken to increase vaccination rate. Vaccine 2013; 31: 518-523.

20. Subrata L, Bizzintino J, Mamessier E, Bosco A, McKenna KL, Wikström ME et al. Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. J. Immunol 2009; 183: 2793-2800.

21. Franza A, Adam O, Willemsa R, et al. Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection J Clin Virol 2010; 48: 239- 245.