Optic neuropathies in childhood: a review of etiology and treatment
Optic neuropathy (ON) is a common problem in childhood resulting fromvarious causes including ischemic, metabolic, hereditary, traumatic andinflammatory events. The latter represents the most prevalent group; the term“optic neuritis” is generally used for this group which can manifest as part ofa systemic inflammatory disease, a central nervous system disorder, or as anisolated entity. The aim of this review is to highlight the clinical characteristicsand treatments of ON for pediatricians, focusing on optic neuritis.
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1. Biousse V, Newman NJ. Ischemic optic neuropathies. N Engl J Med 2015; 372: 2428-2436.2. Behbehani R. Clinical approach to optic neuropathies. Clin Ophthalmol 2007; 1: 233-246.
3. The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Arch Ophthalmol 1991; 109: 1673-1678.
4. Lapeyraque AL, Haddad E, Andre JL, et al. Sudden blindness caused by anterior ischemic optic neuropathy in 5 children on continuous peritoneal dialysis. Am J Kidney Dis 2003; 42: E3-E9.
5. Kim JS, Deputy S, Vives MT, Aviles DH. Sudden blindness in a child with end-stage renal disease. Pediatr Nephrol 2004; 19: 691-693.
6. Matalia J, Kasturi N, Anaspure HD, Shetty BK. Tonic pupil, anterior ischemic optic neuropathy in a teenager with Takayasu arteritis. Can J Ophthalmol 2013; 48: e159-e163.
7. Partal A, Moshfeghi DM, Alcorn D. Churg-Strauss syndrome in a child: retina and optic nerve findings. Br J Ophthalmol 2004; 88: 971-972.
8. Di Zazzo G, Guzzo I, De Galasso L, et al. Anterior ischemic optical neuropathy in children on chronic peritoneal dialysis: report of 7 cases. Perit Dial Int 2015; 35: 135-139.
9. Hayati AA, Wan-Hitam WH, Cheong MT, Yunus R, Shatriah I. Optic neuritis in a child with biotinidase deficiency: case report and literature review. Clin Ophthalmol 2012; 6: 389-395.
10. McAbee GN, Prieto DM, Kirby J, Santilli AM, Setty R. Permanent visual loss due to dietary vitamin A deficiency in an autistic adolescent. J Child Neurol 2009; 24: 1288-1289.
11. Van Stavern GP. Metabolic, hereditary, traumatic, and neoplastic optic neuropathies. Continuum (Minneap Minn) 2014; 20(4 Neuro-ophthalmology): 877-906.
12. Mascialino B, Leinonen M, Meier T. Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe. Eur J Ophthalmol 2012; 22: 461-465.
13. Newman NJ, Biousse V, Newman SA, et al. Progression of visual field defects in leber hereditary optic neuropathy: experience of the LHON treatment trial. Am J Ophthalmol 2006; 141: 1061-1067.
14. Meyerson C, Van Stavern G, McClelland C. Leber hereditary optic neuropathy: current perspectives. Clin Ophthalmol 2015; 9: 1165-1176.
15. Carelli V, Carbonelli M, de Coo IF, et al. International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy. J Neuroophthalmol 2017; 37: 371-381.
16. Skidd PM, Lessell S, Cestari DM. Autosomal dominant hereditary optic neuropathy (ADOA): a review of the genetics and clinical manifestations of ADOA and ADOA+. Semin Ophthalmol 2013; 28: 422-426.
17. Barboni P, Valentino ML, La Morgia C, et al. Idebenone treatment in patients with OPA1-mutant dominant optic atrophy. Brain 2013; 136(Pt 2): e231.
18. Van Stavern GP, Biousse V, Lynn MJ, Simon DJ, Newman NJ. Neuro-ophthalmic manifestations of head trauma. J Neuroophthalmol 2001; 21: 112-117.
19. Ford RL, Lee V, Xing W, Bunce C. A 2-year prospective surveillance of pediatric traumatic optic neuropathy in the United Kingdom. J AAPOS 2012; 16: 413-417.
20. Cakmakli G, Kurne A, Guven A, et al. Childhood optic neuritis: the pediatric neurologist's perspective. Eur J Paediatr Neurol 2009; 13: 452-457.
21. Wilejto M, Shroff M, Buncic JR, Kennedy J, Goia C, Banwell B. The clinical features, MRI findings, and outcome of optic neuritis in children. Neurology 2006; 67: 258-262.
22. Pahor D. Bilateral optic neuritis in a child following Epstein-Barr virus infection. Coll Antropol 2005; 29(Suppl 1): 129-132.
23. Mansor AM, Li HK. Cytomegalovirus optic neuritis: characteristics, therapy and survival. Ophthalmologica 1995; 209: 260-266.
24. Choi SY, Choi YJ, Choi JH, Choi KD. Isolated optic neuritis associated with Mycoplasma pneumoniae infection: report of two cases and literature review. Neurol Sci 2017; 38: 1323-1327.
25. Ahn SJ, Ryoo NK, Woo SJ. Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention. Asia Pac Allergy 2014; 4: 134-141.
26. Venkatesh P, Garg SP, Verma L, et al. Combined optic neuropathy and central retinal artery occlusion in miliary tuberculosis. Retina 2001; 21: 375-377.
27. Moradian S, Ahmadieh H. Early onset optic neuritis following measles-rubella vaccination. J Ophthalmic Vis Res 2008; 3: 118-122.
28. Erguven M, Guven S, Akyuz U, Bilgiç O, Laloglu F. Optic neuritis following hepatitis B vaccination in a 9-year-old girl. J Chin Med Assoc 2009; 72: 594-597.
29. Sugita K, Ando M, Minamitani K, Miyamoto H, Niimi H. Magnetic resonance imaging in a case of mumps postinfectious encephalitis with asymptomatic optic neuritis. Eur J Pediatr 1991; 150: 773-775.
30. Farris BK, Pickard DJ. Bilateral postinfectious optic neuritis and intravenous steroid therapy in children. Ophthalmology 1990; 97: 339-345.
31. Topaloglu H, Berker M, Kansu T, Saatci U, Renda Y. Optic neuritis and myelitis after booster tetanus toxoid vaccination. Lancet 1992; 339: 178-179.
32. Dos Passos GR, Oliveira LM, da Costa BK, et al. MOG-IgG-associated optic neuritis, encephalitis, and myelitis: lessons learned from neuromyelitis optica spectrum disorder. Front Neurol 2018; 9: 217.
33. Carnero Contentti E, De Virgiliis M, Hryb JP, et al. Aquaporin-4 serostatus and visual outcomes in clinically isolated acute optic neuritis. J Neuroophthalmol 2019; 39: 165-169.
34. Lee CG, Lee B, Lee J, Lee M. The natural course of clinically isolated syndrome in pediatric patients. Brain Dev 2015; 37: 432-438.
35. Heussinger N, Kontopantelis E, Gburek-Augustat J, et al; for GRACE-MS (German-speaking Research Alliance for ChildrEn with Multiple Sclerosis). Oligoclonal bands predict multiple sclerosis in children with optic neuritis. Ann Neurol 2015; 77: 1076-1082.
36. Drori T, Chapman J. Diagnosis and classification of neuromyelitis optica (Devic's syndrome). Autoimmun Rev 2014; 13: 531-533.
37. Tenembaum S, Chitnis T, Nakashima I, et al. Neuromyelitis optica spectrum disorders in children and adolescents. Neurology 2016; 87(9 Suppl 2): S59-S66.
38. Wingerchuk DM, Banwell B, Bennett JL, et al; International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015; 85: 177-189.
39. Krupp LB, Tardieu M, Amato MP, et al; International Pediatric Multiple Sclerosis Study Group. International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Mult Scler 2013; 19: 1261-1267.
40. Waldman A, Ness J, Pohl D, et al. Pediatric multiple sclerosis: Clinical features and outcome. Neurology 2016; 87(9 Suppl 2): S74-S81.
41. Averseng-Peaureaux D, Mizzi M, Colineaux H, et al; Kidbiosep Study Group. Paediatric optic neuritis: factors leading to unfavourable outcome and relapses. Br J Ophthalmol 2018; 102: 808-813.
42. Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain 2000; 123(Pt 12): 2407-2422.
43. Kidd D, Burton B, Plant GT, Graham EM. Chronic relapsing inflammatory optic neuropathy (CRION). Brain 2003; 126(Pt 2): 276-284.
44. Petzold A, Plant GT. Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. J Neurol 2014; 261: 17-26.
45. Beck RW, Cleary PA, Anderson MM Jr, et al; The Optic Neuritis Study Group. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N Engl J Med 1992; 326: 581-588.
46. Beck RW, Cleary PA, Trobe JD, et al; The Optic Neuritis Study Group. The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. N Engl J Med 1993; 329: 1764- 1769.
47. Collinge JE, Sprunger DT. Update in pediatric optic neuritis. Curr Opin Ophthalmol 2013; 24: 448-452.
48. Gal RL, Vedula SS, Beck R. Corticosteroids for treating optic neuritis. Cochrane Database Syst Rev 2015; 8: CD001430.
49. Viswanathan S, Wong AH, Quek AM, Yuki N. Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica. J Neuroimmunol 2015; 282: 92-96.
50. Roed HG, Langkilde A, Sellebjerg F, et al. A doubleblind, randomized trial of IV immunoglobulin treatment in acute optic neuritis. Neurology 2005; 64: 804-810.
51. Koziolek M, Mühlhausen J, Friede T, et al. Therapeutic apheresis in pediatric patients with acute CNS inflammatory demyelinating disease. Blood Purif 2013; 36: 92-97.
52. Jacquet C, Garnier A, Cheuret E. Plasma exchange and immunoadsorption in pediatric inflammatory optic neuropathy resistant to corticosteroid therapy: Four French cases. Neuropediatrics 2016; 47: 175- 178.
53. Deschamps R, Gueguen A, Parquet N, et al. Plasma exchange response in 34 patients with severe optic neuritis. J Neurol 2016; 263: 883-887.
54. Black JA, Liu S, Hains BC, Saab CY, Waxman SG. Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain 2006; 129(Pt 12): 3196-3208.
55. Lo AC, Saab CY, Black JA, Waxman SG. Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. J Neurophysiol 2003; 90: 3566-3571.
- ISSN: 0041-4301
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 1958
- Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
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