Serkan KIRIK, Hatice GÜNEŞ, Sadık YURTTUTAN, Nafiz SARIŞIK, Can ACIPAYAM, Yasemin KIRIK

Hemophagocytic lymphohistiocytosis associated with oxcarbazepine

Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening multisystem disorder. Reports of the disorder as a side effect of drugs are extremelyrare. We report the case of a 3-year-old boy with a history of epileptic seizuresin which oxcarbazepine was added to treatment for the last 35 days anddose had been increased. For 10 days he had a fever, hepatosplenomegaly,rash, edema and other systemic symptoms. He was diagnosed with HLHafter bone marrow examination. Oxcarbazepine treatment was terminatedafter the intravenous immunoglobulin treatment. The next day, clinical andlaboratory results had improved. This is the first HLH report of an associationwith oxcarbazepine. Bone marrow aspiration may be indicated to confirm thediagnosis when facing a patient with systemic symptoms after newly addedantiepileptic drug treatment.

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