Evaluation of retinal nerve fiber layer and choroidal thickness with spectral domain optical coherence tomography in children with sickle cell anemia
Background. The aim of this study is to examine the thickness of choroidal, macular and peripapillary retinal nerve fiber layer by spectral-domain optical coherence tomography (SD-OCT) in pediatric patients with sickle cell anemia (SCA) without retinopathy. Methods. A total of 75 children (30 SCA patients (Group 1) and 45 healthy individuals (Group 2) were included in the study. Macular (central, superior, inferior, nasal, temporal), choroidal (subfoveal, at nasal distances from the central fovea of 1000 μm [N1], 2000 μm [N2], 3000 μm [N3], at temporal distances from the central fovea of 1000 μm [T1], 2000 μm [T2], 3000 μm [T3]) and RNFL (average, temporal, superotemporal, inferotemporal, nasal, inferonasal and superonasal) measurements were performed by SD-OCT. These parameters were compared with healthy children with similar demographic characteristics. Results. The mean age was 14.11±3.86 (11-18) in sickle cell anemia patients and 13.15± 2.69 (10-18) in the healthy control group. Of the patients, 56.6% (n=17) of Group 1 and 44.4% (n=20) of Group 2 were male. Choroidal measurements made in the subfoveal, N1, N2, N3, T1, T2 and T3 quadrants showed that the choroid was thinner in 6 quadrants in SCA patients compared to the healthy group (p = 0.003, p = 0.039, p = 0.035, p = 0.595, p = 0.006, p = 0.005, p = 0.047, respectively). In RNFL measurements, there was significant thinning in the temporal, inferotemporal, and nasal quadrants of SCA patients compared to the healthy group. Changes in other quadrants were not significant. Conclusions. SD-OCT is a useful imaging method in the diagnosis and screening in patients with SCA without retinopathy. Early diagnosis of retinopathy during subclinical disease will prevent visual loss in these patients.
___
1. Ünal S. Orak hücreli anemi tedavi ve izlem. Türk Hematoloji Derneği. HematoLog 2014; 4: 79-93.2. Downes SM, Hambleton IR, Chuang EL, Lois N, Serjeant GR, Bird AC. Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study. Ophthalmology 2005; 112: 1869-1875.
3. Fadugbagbe AO, Gurgel RQ, Mendonca CQ, Cipolotti R, dos Santos AM, Cuevas LE. Ocular manifestations of sickle cell disease. Ann Trop Paediatr 2010; 30: 19-26.
4. Elagouz M, Jyothi S, Gupta B, Sivaprasad S. Sickle cell disease and the eye: old and new concepts. Surv Ophthalmol 2010; 55: 359-377.
5. Moriarty BJ, Acheson RW, Condon PI, Serjeant GR. Patterns of visual loss in untreated sickle cell retinopathy. Eye (Lond) 1988; 2(Pt 3): 330-335.
6. Murthy RK, Grover S, Chalam KV. Temporal macular thinning on spectral-domain optical coherence tomography in proliferative sickle cell retinopathy. Arch Ophthalmol 2011; 129: 247-249.
7. Chow CC, Genead MA, Anastasakis A, Chau FY, Fishman GA, Lim JI. Structural and functional correlation in sickle cell retinopathy using spectral domain optical coherence tomography and scanning laser ophthalmoscope microperimetry. Am J Ophthalmol 2011; 152: 704-711.
8. Goldberg MF, Galinos S, Lee CB, Stevens T, Woolf MB. Editorial: macular ischemia and infarction in sickling. Invest Ophthalmol 1973; 12: 633-635.
9. Han IC, Tadarati M, Pacheco KD, Scott AW. Evaluation of macular vascular abnormalities identified by optical coherence tomography angiography in sickle cell disease. Am J Ophthalmol 2017; 177: 90-99.
10. Brasileiro F, Martins TT, Campos SB, et al. Macular and peripapillary spectral domain optical coherence tomography changes in sickle cell retinopathy. Retina 2015; 35: 257-263.
11. Hoang QV, Chau FY, Shahidi M, Lim JI. Central macular splaying and outer retinal thinning in asymptomatic sickle cell patients by spectral-domain optical coherence tomography. Am J Ophthalmol 2011; 151: 990-994.e1.
12. Cai CX, Han IC, Tian J, Linz MO, Scott AW. Progressive retinal thinning in sickle cell retinopathy. Ophthalmol Retina 2018; 2: 1241-1248.e2.
13. Ghasemi Falavarjani K, Scott AW, Wang K, et al. Correlation of multimodal imaging in sickle cell retinopathy. Retina 2016; 36(Suppl 1): S111-S117.
14. Do BK, Rodger DC. Sickle cell disease and the eye. Curr Opin Ophthalmol 2017; 28: 623-628.
15. Hood MP, Diaz RI, Sigler EJ, Calzada JI. Temporal macular atrophy as a predictor of neovascularization in sickle cell retinopathy. Ophthalmic Surg Lasers Imaging Retina 2016; 47: 27-34.
16. Stevens TS, Busse B, Lee CB, Woolf MB, Galinos SO, Goldberg MF. Sickling hemoglobinopathies; macular and perimacular vascular abnormalities. Arch Ophthalmol 1974; 92: 455-463.
17. Fox PD, Dunn DT, Morris JS, Serjeant GR. Risk factors for proliferative sickle retinopathy. Br J Ophthalmol 1990; 74: 172-176.
18. Lim WS, Magan T, Mahroo OA, Hysi PG, Helou J, Mohamed MD. Retinal thickness measurements in sickle cell patients with HbSS and HbSC genotype. Can J Ophthalmol 2018; 53: 420-424.
19. Minvielle W, Caillaux V, Cohen SY, et al. Macular microangiopathy in sickle cell disease using optical coherence tomography angiography. Am J Ophthalmol 2016; 164: 137-144.e1.
20. Mathew R, Bafiq R, Ramu J, et al. Spectral domain optical coherence tomography in patients with sickle cell disease. Br J Ophthalmol 2015; 99: 967-972.
21. Han IC, Tadarati M, Scott AW. Macular vascular abnormalities identified by optical coherence tomographic angiography in patients with sickle cell disease. JAMA Ophthalmol 2015; 133: 1337-1340.
22. Grego L, Pignatto S, Alfier F, et al. Optical coherence tomography (OCT) and OCT angiography allow early identification of sickle cell maculopathy in children and correlate it with systemic risk factors. Graefes Arch Clin Exp Ophthalmol 2020; 258: 2551- 2561.
23. Martin GC, Albuisson E, Brousse V, de Montalembert M, Bremond-Gignac D, Robert MP. Paramacular temporal atrophy in sickle cell disease occurs early in childhood. Br J Ophthalmol 2019; 103: 906-910.
24. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008; 146: 496-500.
25. Vatansever E, Vatansever M, Dinç E, Temel GÖ, Ünal S. Evaluation of ocular complications by using optical coherence tomography in children with sickle cell disease eye findings in children with sickle cell disease. J Pediatr Hematol Oncol 2020; 42: 92-99.
26. Mead B, Tomarev S. Evaluating retinal ganglion cell loss and dysfunction. Exp Eye Res 2016; 151: 96-106.
27. Lonneville YH, Ozdek SC, Onol M, Yetkin I, Gürelik G, Hasanreisoğlu B.The effect of blood glucose regulation on retinal nerve fiber layer thickness in diabetic patients. Ophthalmologica 2003; 217: 347- 350.
28. Leung CK, Tham CC, Mohammed S, et al. In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion. Eye (Lond) 2007; 21: 1464-1468.
29. Akdogan E, Turkyilmaz K, Ayaz T, Tufekci D. Peripapillary retinal nerve fibre layer thickness in women with iron deficiency anaemia. J Int Med Res 2015; 43: 104-109.
30. Chow CC, Shah RJ, Lim JI, Chau FY, Hallak JA, Vajaranant TS.Peripapillary retinal nerve fiber layer thickness in sickle-cell hemoglobinopathies using spectral-domain optical coherence tomography. Am J Ophthalmol 2013; 155: 456-464.e2.
31. Section on Hematology/Oncology Committee on Genetics; American Academy of Pediatrics. Health supervision for children with sickle cell disease. Pediatrics 2002; 109: 526-535.
32. Habibi A, Arlet JB, Stankovic K, et al. French guidelines for the management of adult sickle cell disease: 2015 update. Rev Med Interne 2015; 36(5 Suppl 1): 5S3-5S84.
- ISSN: 0041-4301
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 1958
- Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler
Evaluation of red meat allergy patients and review of the literature
Şeyhan KUTLUĞ, Gonca HANCIOĞLU, Şefika İlknur Karadağ KÖKÇÜ, Recep SANCAK, Fadıl ÖZTÜRK
Tuba ÇELEN YOLDAŞ, Elif Nur ÖZMERT, Berrak BİLGİNER GÜRBÜZ, Halil Tuna AKAR, Turgay COŞKUN
Osman YEŞİLBAŞ, Mehmet YILDIZ, Amra ADROVIC, Sezgin ŞAHİN, KENAN BARUT, Özgür KASAPÇOPUR, Can Yılmaz YOZGAT, Irmak TAHAOĞLU, Hakan YAZAN
Koray YALÇIN, Gülen TÜYSÜZ KİNTRUP, Funda Tayfun KUPESİZ, Alphan KÜPESİZ, Elif GÜLER, Selen BOZKURT
Derya ÖZYÖRÜK, Arzu YAZAL ERDEM, Emel Ünal CABI, Nurdan TAÇYILDIZ, Ferda ALPASLAN PINARLI, Ayşe Selcen OĞUZ, Şahin HANALIOĞLU, Arzu Meltem DEMIR
Kamil YILMAZ, Hasan ÖNCÜL, Veysiye Hülya ÜZEL, Murat SÖKER, Kahraman ÖNCEL, Engin Deniz YILMAZ
Anxiety among the parents of pediatric patients receiving IVIG therapy during the Covid-19 pandemic
Özge YILMAZ TOPAL, Ayşe METİN, Esra ÇÖP, Gulser DİNÇ, Özden Şükran ÜNERİ
Diphallia: a case report of a rare anomaly evaluated by magnetic resonance imaging
M rcio Lu s DUARTE, Lucas Ribeiro dos SANTOS, Andr de Queiroz Pereira da SİLVA, Marcelo de Queiroz Pereira da SİLVA
Burcu AKIN SARI, Hande Ayraler TANER, Zulal Törenli KAYA
Özgün KAYA KARA, Hasan Atacan TONAK, Sedef ŞAHİN, Barkın KÖSE, MUTLUAY ARSLAN, Koray KARA