Cost and length of hospital stay for healthcare facility- onset Clostridioides Difficile infection in pediatric wards: a prospective cohort analysis
Background. Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection, it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the incidence, and economic burden of healthcare facility-onset C. difficile infection (HO-CDI) in children. Methods. Data was acquired with a prospective cohort study conducted in pediatric wards of a tertiary university hospital between August 2015 to August 2016. The HO-CDI was defined as diarrhea that began after 48 hours of admission with a positive cytotoxic stool assay for the presence of toxin A and/or B of C. difficile. Results. In the 3172 admissions in one year, 212 (7%) healthcare associated diarrhea (HAD) episodes were observed, in 25 (12%) of them C. difficile was identified in which 6 (25%) cases
___
1. Adams DJ, Eberly MD, Rajnik M, Nylund CM. Risk factors for community-associated Clostridium difficile infection in children. J Pediatr 2017; 186: 105- 109. https://doi.org/10.1016/j.jpeds.2017.03.0322. Deshpande A, Pant C, Anderson MP, Donskey CJ, Sferra TJ. Clostridium difficile infection in the hospitalized pediatric population: increasing trend in disease incidence. Pediatr Infect Dis J 2013; 32: 1138- 1140. https://doi.org/10.1097/INF.0b013e3182948518
3. Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015; 372: 825-834. https://doi. org/10.1056/NEJMoa1408913
4. Karaaslan A, Soysal A, Yakut N, et al. Hospital acquired Clostridium difficile infection in pediatric wards: a retrospective case-control study. Springerplus 2016; 5: 1329. https://doi.org/10.1186/ s40064-016-3013-8
5. Dubberke ER, Olsen MA. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis 2012; 55(Suppl 2): S88-S92. https://doi.org/10.1093/ cid/cis335
6. Tabak YP, Zilberberg MD, Johannes RS, Sun X, McDonald LC. Attributable burden of hospital-onset Clostridium difficile infection: a propensity scores matching study. Infect Control Hosp Epidemiol 2013; 34: 588-596. https://doi.org/10.1086/670621
7. Mehrotra P, Jang J, Gidengil C, Sandora TJ. Attributable cost of Clostridium difficile infection in pediatric patients. Infect Control Hosp Epidemiol 2017; 38: 1472-1477. https://doi.org/10.1017/ ice.2017.240
8. McDonald LC, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018; 66: e1-e48. https://doi. org/10.1093/cid/cix1085
9. Jangi S, Lamont JT. Asymptomatic colonization by Clostridium difficile in infants; implications for disease in later life. J Pediatr Gastroenterol Nutr 2010; 51: 2-7. https://doi.org/10.1097/ MPG.0b013e3181d29767
10. Enoch DA, Butler MJ, Pai S, Aliyu SH, Karas JA. Clostridium difficile in children: colonisation and disease. J Infect 2011; 63: 105-113. https://doi. org/10.1016/j.jinf.2011.05.016
11. Lees EA, Miyajima F, Pirmohamed M, Carrol ED. The role of Clostridium difficile in the paediatric and neonatal gut- a narrative review. Eur J Clin Microbiol Infect Dis 2016; 35: 1047-1057. https://doi. org/10.1007/s10096-016-2639-3
12. Jangi S, Lamont JT. Asymptomatic colonization by Clostridium difficile in infants implications for disease in later life. J Pediatr Gastroenterol Nutr 2020; 51: 2-7. https://doi.org/10.1097/ MPG.0b013e3181d29767
13. Kukla M, Adrych K, Dobrowolska A, Mach T, Reguła J, Rydzewska G. Guidelines for Clostridium difficile infection in adults. Prz Gastroenterol 2020; 15: 1-21. https://doi.org/10.5114/pg.2020.93629
14. Kim J, Shaklee JF, Smathers S, et al. Risk factors and outcomes associated with severe Clostridium difficile infection in children. Pediatr Infect Dis J 2012; 31: 134-138. https://doi.org/10.1097/ INF.0b013e3182352e2c
15. Nicholson MR, Thomsen IP, Slaughter JC, Creech CB, Edwards KM. Novel risk factors for recurrent Clostridium difficile infection in children. J Pediatr Gastroenterol Nutr 2015; 60: 18-22. https://doi. org/10.1097/MPG.0000000000000553
16. Khalil A, Hendaus MA, Elmagboul E, Mohamed A, Deshmukh A, Elmasoudi A. Incidence of Clostridium difficile infection and associated risk factors among hospitalized children in Qatar. Ther Clin Risk Manag 2019; 15: 1343-1350. https://doi. org/10.2147/TCRM.S229540
17. Nylund CM, Goudie A, Garza JM, Fairbrother G, Cohen MB. Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med 2011; 165: 451-457. https://doi. org/10.1001/archpediatrics.2010.282
18. Tai E, Richardson LC, Townsend J, Howard E, Mcdonald LC. Clostridium difficile infection among children with cancer. Pediatr Infect Dis J 2011; 30: 610- 612. https://doi.org/10.1097/INF.0b013e31820970d1
- ISSN: 0041-4301
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 1958
- Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler
Yeter Düzenli KAR, Zeynep Canan ÖZDEMİR, Kürşat Bora ÇARMAN, Coşkun YARAR, Neslihan TEKİN, Özcan BÖR
The relationship between immature platelet fraction and severity of acute bronchiolitis
Murat DOĞAN, Mehmet KÖSE, Mehmet Adnan ÖZTÜRK, Melih HANGÜL, Hümeyra ASLANER
Mitochondrial trifunctional protein deficiency as a polyneuropathy etiology in childhood
Özlem Ünal UZUN, Büşra ÇAVDARLI, Selen KARALÖK
Evaluation of medication errors in pediatric patients using antibiotics
Nesligül ÖZDEMİR, Emre KARA, Ayşe BÜYÜKÇAM, Kübra AYKAÇ, Ayçe ÇELİKER, Kutay DEMİRKAN, Ateş KARA
Ömer GÖRGÜN, Başak KOÇ, Rejin KEBUDİ, Johannes E WOLFF, Abut KEBUDİ, Emin DARENDELİLER
Yeter DÜZENLİ KAR, Zeynep Canan ÖZDEMİR, Özcan BÖR
Sevliya ÖCAL DEMİR, Eda KEPENEKLİ, Gülşen AKKOÇ, Nurhayat YAKUT, Ahmet SOYSAL
Serdar GÜL, Cemile SÖNMEZ, Gökçe AYVAZ, Selçuk KILIÇ
Parental knowledge about familial Mediterranean fever: a cross-sectional study
Deniz Gezgin YILDIRIM, Sevcan A. BAKKALOĞLU, A. Şebnem SOYSAL ACAR, Necla BUYAN