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Alpha gal specific IgE positivity due to tick bites and red meat allergy: the first case report in Turkey

Galactose-alpha-1,3-galactose is a carbohydrate moiety found in the cellmembranes of many organisms, commonly known as alpha-gal (α-Gal). Thisoligosaccharide is not found in the group of primates in which humans areinvolved. It has been found that α-Gal plays a key role in delayed IgE-mediatedred meat allergy and this allergen is triggered by tick bites. Here we present a7-year-old boy with alpha-gal allergy from Turkey.

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1. Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose. J Allergy Clin Immunol 2009; 123: 426-433.

2. Commins SP, Platts-Mills TAE. Tick bites and red meat allergy. Curr Opin Allergy Clin Immunol 2013; 13: 354-359.

3. Steinke JW, Platts-Mills TAE, Commins SP. The alphagal story: Lessons learned from connecting the dots. J Allergy Clin Immunol 2015; 135: 589-596.

4. Commins SP, Platt-Mills TAE. Anaphylaxis syndrome related to a new mammalian cross-reactive carbohydrate determinant. J Allergy Clin Immunol 2009; 124: 652-657.

5. Chung CH, Mirakhur B, Chan E, et al. Cetuximabinduced anaphylaxis and IgE specific for galactosealpha-1,3-galactose. N Engl J Med 2008; 358: 1109- 1117.

6. Calamari AM, Poppa M, Villalta D, Pravettoni V. Alpha-gal anaphylaxis: The first case report in Italy. Eur Ann Allergy Clin Immunol 2015; 47: 161-162.

7. Kaloga M, Kourouma S, Kouassi YI, et al. Allergy to red meat: A diagnosis made by the patient and confirmed by an assay for IgE antibodies specific for alpha-1,3-galactose. Case Rep Dermatol 2016; 8: 10-13.

8. Platts-Mills TAE, Schuyler AJ, Hoyt AEW, Commins SP. Delayed anaphylaxis involving IgE to galactosealpha-1,3-galactose. Curr Allergy Asthma Rep 2015; 15: 512.

9. Kennedy JL, Stallings AP, Platts-Mills TAE, et al. Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics 2013; 131: e1545-e1552.

10. Muglia C, Kar I, Gong M, Hermes-DeSantis ER, Monteleone C. Anaphylaxis to medications containing meat byproducts in an alpha-gal sensitized individual J Allergy Clin Immunol Pract 2015; 3: 796-797.

11. Brestoff JR, Tesfazghi MT, Zaydman MA, et al. The B antigen protects against the development of red meat allergy. J Allergy Clin Immunol Prac 2018; 6: 1790- 1791.e3.