The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition

Öz Interferon-induced helicase (IFIH1) is a gene locus that has been recently defined as a candidate for susceptibility to generalized vitiligo (GV). The objectives of this study were to assess the association of IFIH1 gene, rs2111485, and rs1990760 single-nucleotide polymorphisms (SNP) with susceptibility to GV and the autoimmune diseases accompanying GV.Materials and methods: We prospectively studied GV patients and frequency-matched healthy controls by age and sex. The genotypes of the participants were determined for rs1990760 and rs2111485 SNPs of IFIH1. Dominant, recessive, and additive models were evaluated for each SNP adjusted for age and sex. Results: The patients and their controls were observed to be in the Hardy-Weinberg equilibrium for SNP1 (2q24.2, rs1990760, IFIH1, T/C) and SNP2 (2q24.2, rs2111485, IFIH1, G/A), respectively (all P > 0.7). For SNP1, every T allel addition was significantly associated with 1.53 times protectiveness in terms of vitiligo risk (P = 0.033). As for SNP2, every G allel addition was associated with 1.42 times protectiveness, close to statistical significance (P = 0.100). Conclusions: We detected that for SNP1, each T allel and for SNP2, each G allel are protective in terms of vitiligo development. Hereby, we confirmed that IFIH1 gene locus has a role in GV susceptibility.

Kaynak Göster

Bibtex @ { tbtkmedical577798, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {206 - 211}, doi = {}, title = {The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition}, key = {cite}, author = {Onan, Duru and Yorulmaz, Ahu and Ezgü, Fatih Süheyl and Hayran, Kadir Mutlu and Çakmak, Seray Külcü and Artüz, Refika Ferda and Yalçın, Başak} }
APA Onan, D , Yorulmaz, A , Ezgü, F , Hayran, K , Çakmak, S , Artüz, R , Yalçın, B . (2019). The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition . Turkish Journal of Medical Sciences , 49 (1) , 206-211 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577798
MLA Onan, D , Yorulmaz, A , Ezgü, F , Hayran, K , Çakmak, S , Artüz, R , Yalçın, B . "The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition" . Turkish Journal of Medical Sciences 49 (2019 ): 206-211 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577798>
Chicago Onan, D , Yorulmaz, A , Ezgü, F , Hayran, K , Çakmak, S , Artüz, R , Yalçın, B . "The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition". Turkish Journal of Medical Sciences 49 (2019 ): 206-211
RIS TY - JOUR T1 - The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition AU - Duru Onan , Ahu Yorulmaz , Fatih Süheyl Ezgü , Kadir Mutlu Hayran , Seray Külcü Çakmak , Refika Ferda Artüz , Başak Yalçın Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 206 EP - 211 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition %A Duru Onan , Ahu Yorulmaz , Fatih Süheyl Ezgü , Kadir Mutlu Hayran , Seray Külcü Çakmak , Refika Ferda Artüz , Başak Yalçın %T The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD Onan, Duru , Yorulmaz, Ahu , Ezgü, Fatih Süheyl , Hayran, Kadir Mutlu , Çakmak, Seray Külcü , Artüz, Refika Ferda , Yalçın, Başak . "The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 206-211 .
AMA Onan D , Yorulmaz A , Ezgü F , Hayran K , Çakmak S , Artüz R , Yalçın B . The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition. Turkish Journal of Medical Sciences. 2019; 49(1): 206-211.
Vancouver Onan D , Yorulmaz A , Ezgü F , Hayran K , Çakmak S , Artüz R , Yalçın B . The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition. Turkish Journal of Medical Sciences. 2019; 49(1): 206-211.
IEEE D. Onan , A. Yorulmaz , F. Ezgü , K. Hayran , S. Çakmak , R. Artüz ve B. Yalçın , "The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 206-211, Şub. 2019

9101 7126

Arşiv
Sayıdaki Diğer Makaleler

Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance

Rafiye ÇİFTÇİLER, Ahmet KOLUMAN, İbrahim Celalettin HAZNEDAROĞLU, Nejat AKAR

Evaluation of myocardial dispersion of repolarization in patients with heart transplantation

Cengiz BURAK, Erkan BAYSAL, Muhammed SÜLEYMANOĞLU, Çağri YAYLA, Serkan ÇAY, Ümit KERVAN

Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran

Maryam MOHAMMADBEIGI, Zahra Safayi DELOUYI, Nima MOHAMMADZADEH, Arash ALA&#039;ALMOHADESIN, Keyvan TAHERI, Elahe EDALATI, Mansour SEDIGHI, Abed Zahedi BIALVAEI

Evaluation of measles immunity in Turkey: is it still a threat?

Selda KARAAYVAZ, Melahat Melek OĞUZ, Ufuk BEYAZOVA, Fatma Gülay KORUKLUOĞLU, Yasemin COŞGUN, Zeliha GÜZELKÜÇÜK, Fatma Nur Baran AKSAKAL, Figen Şahin DAĞLI

Does chest compression during cardiopulmonary resuscitation provide sufficient cerebral oxygenation?

Mehmet Akif YAZAR, Mehmet Bariş AÇIKGÖZ, Adnan BAYRAM

Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients

Rabia Lebriz Uslu BEŞLİ, Muhammet Sait SAĞER, Elife AKGÜN, Sertaç ASA, Onur Erdem ŞAHİN, Çetin DEMİRDAĞ, Ekrem GÜNER, Seyedbaresh RAZAVİKHOSROSHAHİ, Emre KARAYEL, Hüseyin PEHLİVANOĞLU, Aslan AYGÜN, İlhami USLU, Zübeyr TALAT, Kerim SÖNMEZOĞLU

Differentiation between intestinal Behçet's disease and Crohn's disease based on endoscopy

Jing Fen YE, Jian Long GUAN

Do PD-1 and PD-L2 expressions have prognostic impact in hematologic malignancies?

Serdal KORKMAZ, Selahattin ERDEM, Ebru AKAY, Erdem Arzu TAŞDEMİR, Hatice KARAMAN, Muzaffer KEKLİK

The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients

Canan Albayrak YAŞAR, Pinar TARKUN, Elif Birtaş ATEŞOĞLU, Fatma Ceyla ERALDEMİR, Özgür Doğa ÖZSOY, Esra Terzi DEMİRSOY, Özgür MEHTAP, Ayfer GEDÜK, Abdullah HACİHANİFİOĞLU

Abnormal retinal microvasculature found in active rheumatoid arthritis:a different perspective of microvascular health

Hakan BABAOĞLU, Ata BAYTAROĞLU, Murat TORĞUTALP, Abdulsamet ERDEN, Sibel KADAYIFÇILAR, Umut KALYONCU