The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation

Öz Background/aim: After allogeneic hematopoietic stem cell transplantation (allo-HSCT), donor natural killer (NK) cells trigger alloreactions against potential recipient cells by their killer immunoglobulin-like receptors (KIRs). This study investigated whether KIR/HLA genotypes and KIR haplotypes of donors and recipients exhibit a critical function in the prevalence of acute graft-versus-host disease (aGVHD) and persistence of the graft after HLA-identical sibling allo-HSCT for patients with hematological malignancies. Materials and methods: We studied KIR and HLA genotypes in 115 related donors and recipients (56 patients with AML and 59 patients with ALL) who had received allo-HSCT from HLA-matched sibling donors. We evaluated 17 KIR genes and some alleles, including their ligands, using the PCR-SSP assay. Results: KIR gene frequency results between donors and recipients showed that donors had more activating KIR than their recipients. Chi-square comparison of KIR genotype frequencies in donors versus recipients revealed a significant difference (P < 0.001). We found a survival association between the donor lacking and the recipient having group B KIR haplotypes, although this was not statistically significant. Conclusion: This study suggests that we could exploit NK cell alloreactivity as a part of the optimization of donor selection and potential immunotherapeutic regimens to help facilitate good engraftment and reduce the risk of aGVHD incidence after allo-HSCT.

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Bibtex @ { tbtkmedical576725, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {794 - 804}, doi = {}, title = {The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation}, key = {cite}, author = {Hoseinian, Seyed Ahmad and Jafari, Davood and Mahmoodi, Mehdi and Alimoghaddam, Kamran and Ostadali, Mohammadreza and Bonakdar, Azita Talebzadeh and Foma, Arron Munggela and Yekaninejad, Mir Saeed and Amirzargar, Ali Akbar} }
APA Hoseinian, S , Jafari, D , Mahmoodi, M , Alimoghaddam, K , Ostadali, M , Bonakdar, A , Foma, A , Yekaninejad, M , Amirzargar, A . (2018). The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation . Turkish Journal of Medical Sciences , 48 (4) , 794-804 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576725
MLA Hoseinian, S , Jafari, D , Mahmoodi, M , Alimoghaddam, K , Ostadali, M , Bonakdar, A , Foma, A , Yekaninejad, M , Amirzargar, A . "The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation" . Turkish Journal of Medical Sciences 48 (2018 ): 794-804 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576725>
Chicago Hoseinian, S , Jafari, D , Mahmoodi, M , Alimoghaddam, K , Ostadali, M , Bonakdar, A , Foma, A , Yekaninejad, M , Amirzargar, A . "The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation". Turkish Journal of Medical Sciences 48 (2018 ): 794-804
RIS TY - JOUR T1 - The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation AU - Seyed Ahmad Hoseinian , Davood Jafari , Mehdi Mahmoodi , Kamran Alimoghaddam , Mohammadreza Ostadali , Azita Talebzadeh Bonakdar , Arron Munggela Foma , Mir Saeed Yekaninejad , Ali Akbar Amirzargar Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 794 EP - 804 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation %A Seyed Ahmad Hoseinian , Davood Jafari , Mehdi Mahmoodi , Kamran Alimoghaddam , Mohammadreza Ostadali , Azita Talebzadeh Bonakdar , Arron Munggela Foma , Mir Saeed Yekaninejad , Ali Akbar Amirzargar %T The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD Hoseinian, Seyed Ahmad , Jafari, Davood , Mahmoodi, Mehdi , Alimoghaddam, Kamran , Ostadali, Mohammadreza , Bonakdar, Azita Talebzadeh , Foma, Arron Munggela , Yekaninejad, Mir Saeed , Amirzargar, Ali Akbar . "The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 794-804 .
AMA Hoseinian S , Jafari D , Mahmoodi M , Alimoghaddam K , Ostadali M , Bonakdar A , Foma A , Yekaninejad M , Amirzargar A . The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation. Turkish Journal of Medical Sciences. 2018; 48(4): 794-804.
Vancouver Hoseinian S , Jafari D , Mahmoodi M , Alimoghaddam K , Ostadali M , Bonakdar A , Foma A , Yekaninejad M , Amirzargar A . The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation. Turkish Journal of Medical Sciences. 2018; 48(4): 794-804.
IEEE S. Hoseinian , D. Jafari , M. Mahmoodi , K. Alimoghaddam , M. Ostadali , A. Bonakdar , A. Foma , M. Yekaninejad ve A. Amirzargar , "The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 794-804, Ağu. 2018

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