The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Öz Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. Materials and methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment.Results: In AV patients, pretreatment HOMA-IR and adipocytokine levels were not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values were found (P = 0.028). Isotretinoin therapy maintained lower mean resistin levels (P = 0.016), higher mean RBP4 levels (P = 0.040), but not affected the mean adiponectin and leptin levels (P = 0.113, P = 0.125, respectively). Conclusions: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in in-sulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients.

Kaynak Göster

Bibtex @ { tbtkmedical577807, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {238 - 244}, doi = {}, title = {The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients}, key = {cite}, author = {Soyuduru, Gonca and Adışen, Esra Özsoy and Özer, İlkay and Aksakal, Ahmet Burhan} }
APA Soyuduru, G , Adışen, E , Özer, İ , Aksakal, A . (2019). The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients . Turkish Journal of Medical Sciences , 49 (1) , 238-244 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577807
MLA Soyuduru, G , Adışen, E , Özer, İ , Aksakal, A . "The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients" . Turkish Journal of Medical Sciences 49 (2019 ): 238-244 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577807>
Chicago Soyuduru, G , Adışen, E , Özer, İ , Aksakal, A . "The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients". Turkish Journal of Medical Sciences 49 (2019 ): 238-244
RIS TY - JOUR T1 - The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients AU - Gonca Soyuduru , Esra Özsoy Adışen , İlkay Özer , Ahmet Burhan Aksakal Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 238 EP - 244 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients %A Gonca Soyuduru , Esra Özsoy Adışen , İlkay Özer , Ahmet Burhan Aksakal %T The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD Soyuduru, Gonca , Adışen, Esra Özsoy , Özer, İlkay , Aksakal, Ahmet Burhan . "The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 238-244 .
AMA Soyuduru G , Adışen E , Özer İ , Aksakal A . The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients. Turkish Journal of Medical Sciences. 2019; 49(1): 238-244.
Vancouver Soyuduru G , Adışen E , Özer İ , Aksakal A . The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients. Turkish Journal of Medical Sciences. 2019; 49(1): 238-244.
IEEE G. Soyuduru , E. Adışen , İ. Özer ve A. Aksakal , "The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 238-244, Şub. 2019

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